A5035392223- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Gut microbiota and health
- Kruppel-like factors research
- Surgical Sutures and Adhesives
- Silk-based biomaterials and applications
- Diabetes Treatment and Management
- Body Contouring and Surgery
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Digestive system and related health
- Macrophage Migration Inhibitory Factor
- Neurological and metabolic disorders
- Dietary Effects on Health
- Reconstructive Surgery and Microvascular Techniques
Fudan University
2015-2025
Huashan Hospital
2016-2025
University of Michigan
2022
Regenerating islet-derived protein 3g (Reg3g), a gut peptide has been implicated in host defense and various physiological functions including metabolic regulation. Emerging evidence demonstrated that peripheral administration of Reg3g results improved glucose regulation as hormone. In this study, we explore the therapeutic potential through intraduodenal infusion mouse models disorders. The objective study was to test hypothesis administering into intestinal lumen contributes improvements...
Vertical Sleeve Gastrectomy (VSG) is one of the most efficacious treatments for obesity and its comorbidities. Although a range evidence suggests that alterations microbiota in distal gut following VSG are pivotal to these metabolic improvements, effect surgery alter proximal intestine on host physiology remain largely unknown. As main bacteria upper small intestine, Lactobacillus subspecies have been appreciated as important regulators function. These also regulate intestinal Hypoxia-...
Abstract Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive, but provide most effective long-term metabolic improvements in obese and Type 2 diabetic patients. These powerful effects of manipulating gastrointestinal tract point to an important role signals regulating both energy balance metabolism. To that end, we have used mouse models VSG identify key gut mediate these beneficial effects. Preliminary data from our rodent model led us hypothesize a potential for...