A5068421341- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Cytokine Signaling Pathways and Interactions
- Neurological disorders and treatments
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Immunotherapy and Immune Responses
- Peripheral Neuropathies and Disorders
- Glutathione Transferases and Polymorphisms
- Growth Hormone and Insulin-like Growth Factors
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Parasitic Infections and Diagnostics
- Vascular Tumors and Angiosarcomas
- Powdery Mildew Fungal Diseases
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Cancer Risks and Factors
Lasarettet i Motala
2018-2023
Linköping University Hospital
2023
University of Gothenburg
2006-2022
Sahlgrenska University Hospital
2000-2014
Skaraborg Hospital
2014
Neuroscience Institute
2010
<b><i>Objective:</i></b> To determine if CNS-derived proteins present in the CSF of multiple sclerosis (MS) patients reflect different pathologic processes MS and these could be useful as biologic markers disease activity. <b><i>Methods:</i></b> Concentrations neurofilament light protein (NFL), glial fibrillary acidic (GFAP), S100B, neuron-specific enolase (NSE) were determined 66 50 healthy control subjects with immunoassays. <b><i>Results:</i></b> The mean levels NFL increased during all...
Objectives: To evaluate the efficacy and safety of dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease (HD). Methods: In a randomized, double-blind, placebo-controlled, 4-week trial, HD received (50 mg/d, n = 28) or placebo (n 30). The primary outcome measure was change from baseline weighted cognitive score, assessed by tests (Symbol Digit Modalities, verbal fluency, Stroop tests). Secondary measures included changes Unified Disease Rating Scale, Hospital...
Background Cell and animal experiments have shown that β-site APP-cleaving enzyme 1 (BACE1) may be involved in myelination. Objective Here, we assess the association of cerebrospinal fluid (CSF) BACE1 activity with multiple sclerosis (MS). Methods levels secreted amyloid precursor protein (APP) amyloid-β (Aβ) isoforms were analyzed CSF from 100 patients MS 114 neurologically healthy controls. Patients systemic lupus erythematosus (SLE), 26 41 without cerebral engagement, also included to...
A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform cystatin C (CysC) as specific biomarker for multiple sclerosis (MS).Surface-enhanced samples from 43 MS patients and 46 healthy control subjects.Full-length CysC (13.4 kDa) concentration was similar in samples. The protein produced full-length by N-terminal cleavage during storage at -20 degrees C.The is storage-related artifact not useful...
Abstract Novel biomarkers for multiple sclerosis (MS) could improve diagnosis and provide clues to pathogenesis. In this study surface‐enhanced laser desorption/ionization time‐of‐flight mass spectrometry was used analyze protein expression in CSF from 46 MS patients, healthy siblings the 50 unrelated controls. Twenty‐four proteins range 2–10 kDa were expressed at significantly different levels ( p < 0.01) a robust manner when comparing three groups. Identities of determined using...
To test the hypothesis that arachodinic acid metabolites prostaglandin E2 (PGE2) and 15-(S)-hydroxyeicosatetraenoic (15(S)-HETE) in cerebrospinal fluid (CSF) are elevated reflect neuroinflammation degenerative changes multiple sclerosis (MS).We measured PGE2 15(S)-HETE concentrations, as well markers of axonal astroglial injury CSF from 46 MS patients, healthy siblings 50 controls.We found levels both compared with control sibling groups. Siblings had lower higher than controls. There were...
Objective To evaluate the safety (primary objective) and efficacy (secondary of (−)-OSU6162 in Huntington’s disease (HD). Methods In a double-blind, cross-over trial, patients with HD were randomly assigned to start treatment on either or placebo. After 4 weeks, those who initially received active drug switched placebo for another vice versa. During first week dose was 15 mg twice daily, during second 30 last 2 weeks 45 daily. Motor, cognitive, mental social functions rated by clinical...
In a previous study we found that nine of 47 siblings to multiple sclerosis (MS) patients with normal neurological examination carry an intrathecal oligoclonal immunopathy limited specificity, condition termed MS immunopathic trait. The purpose this is further characterize the trait phenotype. We neurofilament light protein (NFL) and glial fibrillary acidic (GFAp) concentrations were increased in group clinically definite (n = 47) latent or slowly progressive phases. There was no increase...
Haghighi S, Lekman A, Nilsson Blomqvist M, Andersen O. Myelin glycosphingolipid immunoreactivity and CSF levels in multiple sclerosis. Acta Neurol Scand: 2012: 125: 64–70. © 2011 John Wiley & Sons A/S. Objectives – Patients with sclerosis were reported to harbour antibodies not only against proteins glycoproteins but also glycolipids, including sulfatide galactosylceramide (GalCer), the two major glycosphingolipids of myelin. However, previous results inconsistent concerning levels, antibody...
Much is unknown regarding the regulation of Alzheimer-related amyloid-β protein precursor (AβPP)-processing in human central nervous system. It has been hypothesized that amyloidogenic AβPP-processing preferentially occurs regulated secret
We studied two extended families in which not only multiple sclerosis (MS) segregates, but also approximately 18% of the cerebrospinal fluid (CSF) investigated blood relatives have ‘MS immunopathic trait’, an oligoclonal CSF immunopathy similar to that seen MS, with no neurological symptoms. Both fit a genetic model for autosomal dominant inheritance MS trait, although reduced penetrance family A. In order identify factors importance development we performed genome scan using CHLC/Weber...
RebiQoL was a phase IV multicenter randomized study to assess the impact of telemedicine patient support program (MSP) on health-related quality life (HRQoL) in patients with relapsing-remitting MS (RRMS) being administered Rebif RebiSmart device. The primary endpoint MSP compared only receiving technical for HRQoL at 12 months, using psychological part Multiple Sclerosis Impact Scale (MSIS-29), Rebif. A total 97 diagnosed RRMS were screened participation which 3 did not fulfill eligibility...
We analysed HLA haplotypes in pairs of 78 sporadic multiple sclerosis (MS) patients and healthy siblings. The presence 2 oligoclonal IgG bands, detected by immunoblotting the cerebrospinal fluid siblings, has previously been defined as MS immunopathic trait (MSIT), based on a cut-off derived from unrelated volunteers. frequency MSIT was 17.9% (n=14/78 siblings). HLA-DR(15)2 allelle present 21.4% (n=3/14) siblings with MSIT, 40.6% (n =26/64) without 59% =46/78) clinically-definite (CD) MS....