Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation can be made further effective by utilizing nanoparticles high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose maximizing the within tumors, bovine serum albumin capped gadolinium oxide and gold (Gd2O3@BSA-Au NPs) are developed a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au Gd, single nanoplatform. The...

The aim of this study is to evaluate the effects sildenafil citrate on cisplatin-induced ovarian toxicity. Thirty-two female rats were divided into four groups. Group 1: saline control; group 2: cisplatin; 3: citrate; and 4: cisplatin plus group. In groups 2 4, injected with 5 mg/kg intraperitoneally (i.p.). 3 1.4 i.p. ovaries removed two weeks later in all Histopathologic examination, follicle counting classification performed. expression anti-Müllerian hormone (AMH) was detected...

Objectives: This study aimed to elucidate the effects of messenger RNA (mRNA) and inactivated coronavirus disease 2019 (COVID-19) vaccines on ovarian histology reserve in rats. Methods: Thirty female Wistar albino rats, aged 16–24 weeks, were randomly divided into three groups (n = 10): control, mRNA vaccine, vaccine groups. Each group received two doses (on day 0 28) at human-equivalent doses. Four weeks post-second vaccination, tissues harvested for analysis. Results: Immunohistochemical...

Purpose Although radiation is one of the basic methods commonly used in cancer treatment, it inevitably enters field treatment healthy tissues and adversely affected by acute chronic side effects radiation. This study evaluated possible protective quercetin, an antioxidant agent, against liver kidney damage rats exposed to a whole-body single dose (10 Gy gamma-ray).Materials The groups were formed as control, sham, radiation, quercetin + using 60 male Wistar albino (200–250 g, 3 months old)...

Numerous grafting materials have been used to augment the maxillary sinus floor for long-term stability and success implant-supported prosthesis. To enhance bone formation, adjunctive blood-born growth factor sources gained popularity during recent years. The present study compared use of platelet-rich fibrin (PRF) bovine-autogenous mixture elevation. A split-face model was apply 2 different filling elevation in 22 healthy adult sheep. In group 1, bovine autogenous mixture; 2, PRF used....

Nitric oxide (NO) plays a significant role in the development of diabetic nephropathy. We investigated effects an antioxidant, carnosine, on streptozotocin (STZ)-induced renal injury rats. used four groups eight rats: group 1, control; 2, carnosine treated; 3, untreated diabetic; 4, treated diabetic. Kidneys were removed and processed, sections stained with periodic acid-Schiff (PAS) subjected to eNOS immunohistochemistry. Examination by light microscopy revealed degenerated glomeruli,...

Ototoxicity is a health problem appearing after powerful treatments in serious conditions. It sometimes inevitable when treatment of the disease required. Cisplatin an antineoplastic agent which was investigated previously to reveal increased nitrogen and reactive oxygen radicals that damages hair cells, resulting ototoxicity. N-acetylcysteine, shown decrease ototoxicity caused by different agents, known be vitro antioxidant. Probably addition its antioxidant effect, blocks cascade where...

Doxorubicin (DOX) is a widely used drug for the treatment of cancer,but its clinical use limited by liver toxicity. Administering DOX with an antioxidant has become strategy preventing side effects DOX. Although selenium (Se) important trace mineral, data concerning effect Se on induced tissue are lacking. We investigated mechanism hepatotoxicity and protective different doses Dox damage. Female Wistar albino rats were divided into eight equal groups. was injected intraperitoneally (i.p.) to...

We investigated the myotoxic effects of bupivacaine, ropivacaine and levobupivacaine on rat skeletal muscle compared its apoptotic activity acute pro-nflammatory cytokines. divided 40 Wistar albino rats into four equal groups. Rats were injected intramuscularly with 0.5% bupivacaine (group B), R), L) or 0.9% normal saline SF). Animals sacrificed second day after injection. TNF-α, IL-1 IL-6 levels examined in tissue using immunohistochemistry immunofluorescence. Apoptotic cells visualized by...

Purpose The sequelae of premature loss ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one the most relevant treatment modalities various types malignancies. aim this study was to determine effect different doses radiation on folliculogenesis, inflammation, and apoptotic markers.Materials methods For purpose, 40 healthy Wistar albino female rats divided into four groups: 1) Control group; 2) those that were exposed total body 1 Gy gamma rays; 3)...

Introduction: The aim of the current study was to look into any potential ameliorative benefits boric acid on liver damage in rats caused by cyclophosphamide (CTX). 
 Materials and Methods: Four groups; control, acid, CTX, + were created. Female Wistar albino given daily injections CTX (75 mg/kg) create model. Cyclophosphamide administered intraperitoneally, boron (1.3 g/rat/day) gavage every day for two weeks acid+CTX group. histopathological changes evaluated ovarian tissue staining...

Epidemiological studies have shown that low to moderate doses of alcohol consumption are beneficial cardiac health. However, chronic high ingestion cause cardiovascular complications. The aim this study was investigate both the effects melatonin and vitamin C expression endothelial nitric oxide synthase in aorta alcoholic rats. Twenty-four adult male Wistar rats weighing 200-250 g were used study. Rats divided into four equal groups. Group I (control): not fed on alcohol; II: III: 40 mg/kg...

We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) the protective effect of melatonin treatment NP induced damage. used 21 female rats divided randomly into three groups: control, + NP. Histopathological examination ovaries, counting classification follicles were performed Masson's trichrome staining. Expression anti-Mullerian hormone (AMH), Bax, Bcl-2 caspase-3 was detected in ovaries immunohistochemistry. Melatonin had an ameliorative on...

Background and Objectives: Contrast-induced nephropathy (CIN), is acute renal damage due to contrast agents. This study conducted evaluate serum heterodimeric nuclear transcription factor (HIF)-2 alpha levels its tissue expression in contrast-induced nephropathy, N-acetyl cysteine (NAC)-and Sildenafil-treated rat models. Materials/Methods: randomized, controlled, interventional animal was on Wistar rats. Rats (n = 36) were randomly assigned four groups: control 9), CIN group + NAC sildenafil...

The aim of the study is to investigate effects interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, gonadotropin-releasing hormone antagonist (GnRHA), cabergoline. Forty-seven rats were randomly divided into following seven groups: Group 1: OHS; 2: OHS+ GnRHA; 3: OHS + ranibizumab; 4: cabergoline; 5: low-dose (TL); 6: high-dose (TH); 7: sham. Ovarian weight was significantly lower only ranibizumab group than group. Estrogen levels GnRHA...

To evaluate hyperbaric oxygen therapy (HBO) based on ovarian histology, total antioxidant status (TAS), oxidant (TOS), and anti-müllerian hormone (AMH), in the insufiency (POI) model created with cyclophosphamide (CYP).The rats were separated into 3 groups of control group (n=6), CYP CYP+HBO (n=6). The injected intraperitoneally 200 mg/kg day 1, followed by 8 mg/kg/day for 14 days to create POI. From 15th onwards, placed a cabin exposed 100% at 2.4 atm pressure one h, then returned their...