A5042934955- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Microbial Natural Products and Biosynthesis
- Molecular spectroscopy and chirality
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Polyamine Metabolism and Applications
- Advanced NMR Techniques and Applications
- Synthesis and Biological Evaluation
- Alkaloids: synthesis and pharmacology
- Catalytic C–H Functionalization Methods
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
Indian Institute of Chemical Technology
2014-2019
University of Hyderabad
2016
Osmania University
2016
The syntheses and applications of peptidomimetic triazole-based catalysts are described as efficient organocatalysts in Michael reaction with low loading.
The three-component Povarov reaction is efficiently utilized for construction of the pentacyclic framework complex Melodinus alkaloids, which amenable to expansion other natural products. key steps were reaction, one-pot reductive cyclization, and ring-closing metathesis (RCM) reaction.
Some novel chemically modified frameworks of ursolic acid have been designed and synthesized. The key step was the cycloaddition azidopropyl-3β-hydroxy-urs-12-en-28-oate with appropriate C28 propargyl esters ursolic, corosolic, asiatic, oleanolic, betulinic under Click reaction conditions, products were obtained in 74-84% yields. In view their intriguing structural diversity, they subjected to detailed 1D 2D NMR studies structures are thoroughly assigned. synthesized compounds screened for...
Abstract A strategy has been devised for the stereoselective synthesis of hexahydroindeno[2,1‐ c ]pyran scaffolds through a domino cyclization ( E )‐3,5‐diphenylpent‐4‐en‐1‐ol with aldehydes using BF 3 ⋅ OEt 2 at 70 °C. It is an approach construction indeno[2,1‐ skeleton in one‐pot operation cascade cyclization.
Abstract A tandem bicyclization strategy has been developed for the stereoselective synthesis of 3,4‐dihydro‐2 H ,6 ‐2,6‐methanobenzo[ b ][1,5]dioxocine derivatives in good yields and selectivities through cyclocondensation 2‐(1‐hydroxy‐3‐methylbut‐3‐en‐1‐yl)phenol with various aldehydes by using 10 mol % BF 3 ⋅ OEt 2 . This is first reported construction a bridged tricyclic skeleton cascade Prins cyclization procedure. process constitutes an elegant quick architectures single step.
A broad range of aldehydes undergo a smooth cascade cyclization with (E)-5-(3-phenylprop-2-ynylamino)pent-3-en-1-ol in the presence BF3·OEt2 at room temperature to furnish novel series (octahydro-1H-pyrano[3,4-c]pyridin-5-yl)methanone derivatives good yields and diastereoselectivities. This process provides simple proficient alternative for stereoselective construction fused pyranopiperidine derivatives.
Abstract Total synthesis of the revised cryptorigidifoliol K and 2′‐ epi ‐cryptorigidifoliol was accomplished. Salient features involve tandem isomerization followed by C−O C−C bond forming reaction, iodolactonization Nozaki‐Hiyama‐Kishi reaction. The allowed for confirmation structure as well elucidation unassigned stereocenter present in side chain correlating spectral analytical data synthetic with natural product data, which found to be 1 S ,5 R ,7 ,2′ ,3′ E .
Abstract We describe herein design, synthesis and conformational investigations of polypeptides attached on a rigid dimedone template. Two identical peptide chains are single carbon containing as scaffold. Dimedone assists in controlling the secondary interactions through strong intramolecular helical C‐12 C‐15 membered bifurcated hydrogen bonding both along with propagating architecture attached. There exists C‐6 for stranded peptides to dimedone. Extensive structural involving crystal...
Abstract Treatment of (E)‐diphenylalkenes bearing a primary ethanol side chain with aliphatic or aromatic aldehydes under conditions A) produces the desired tricyclic heterocycle as scaffold various natural substances and pharmaceutical agents.
Abstract Nitrones generated in situ from aldehydes (I) and hydroxylamines undergo intramolecular cycloaddition to give isoxazolines (II) isoxazolidines (IV) with high diastereoselectivity.