A5104977372- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Hormonal Regulation and Hypertension
- Photosynthetic Processes and Mechanisms
- Pharmacogenetics and Drug Metabolism
- Coenzyme Q10 studies and effects
- Eicosanoids and Hypertension Pharmacology
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- melanin and skin pigmentation
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Catalytic Alkyne Reactions
- Mitochondrial Function and Pathology
Goethe University Frankfurt
2020-2021
Laboratoire de Chimie Organique
2018
Unité de Recherche en Chimie Organique et Macromoléculaire
2018
National Institute of Pharmaceutical Education and Research
2013-2014
Indian Institute of Chemical Technology
2014
Abstract A series of imidazo[2,1‐ b ][1,3,4]thiadiazole‐linked oxindoles composed an A, B, C and D ring system were synthesized investigated for anti‐proliferative activity in various human cancer cell lines; test compounds variously substituted at rings D. Among them, 7 (( E )‐5‐fluoro‐3‐((6‐ p ‐tolyl‐2‐(3,4,5‐trimethoxyphenyl)‐imidazo[2,1‐ ][1,3,4]thiadiazol‐5‐yl)methylene)indolin‐2‐one), 11 )‐3‐((6‐ ‐tolyl‐2‐(3,4,5‐trimethoxyphenyl)imidazo[2,1‐ 15...
The respiratory chain of Escherichia coli contains two different types terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction molecular oxygen water and contribute proton motive force. cytochrome bo
Lead-optimization strategies for compounds targeting c-Myc G-quadruplex (G4) DNA are being pursued to develop anticancer drugs. Here, we investigate the structure-activity- relationship (SAR) of a newly synthesized series molecules based on pyrrolidine-substituted 5-nitro indole scaffold target G4 DNA. Our allows modulation flexible elements with structurally preserved scaffold. Biological and biophysical analyses illustrate that substituted 5-nitroindole scaffolds bind promoter...
Abstract Functionalization of key intermediate (IV) furnishes 29 different benzofuran derivatives, e.g. (V).