A5052815912- Extracellular vesicles in disease
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Photoacoustic and Ultrasonic Imaging
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Neuroscience and Neural Engineering
- Fault Detection and Control Systems
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Additive Manufacturing and 3D Printing Technologies
- Biomarkers in Disease Mechanisms
- Nanopore and Nanochannel Transport Studies
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Lymphatic System and Diseases
- Pulmonary Hypertension Research and Treatments
- Fuel Cells and Related Materials
University of Notre Dame
2021-2024
Current biomarkers for myocardial infarction (MI) diagnosis are typically late markers released upon cell death, incapable of distinguishing between ischemic and reperfusion injury can be symptoms other pathologies. Circulating microRNAs (miRNAs) have recently been proposed as alternative MI diagnosis; however, detecting the changes in human cardiac miRNA profile during is extremely difficult. Here, to study levels acute MI, a heart-on-chip model with channel, containing induced pluripotent...
Fibrotic tissue formed after myocardial infarction (MI) can be as detrimental MI itself. However, current in vitro cardiac fibrosis models fail to recapitulate the complexities of post-MI tissue. Moreover, although and subsequent is most prominent aged population, field suffers from inadequate models. Herein, an human model, representing native microenvironment weeks initial infarction, engineered using three-dimensional bioprinting via creation individual bioinks specifically mimic three...
Micro RNAs (miRNAs) have shown great potential as rapid and discriminating biomarkers for acute myocardial infarction (AMI) diagnosis. We developed a multiplexed ion-exchange membrane-based miRNA (MIX·miR) preconcentration/sensing amplification-free platform quantifying in parallel panel of miRNAs, including miR-1, miR-208b, miR-499, from the same plasma samples from: 1) reference subjects with no evident coronary artery disease (NCAD); 2) stable (CAD); 3) experiencing ST-elevation (STEMI)...
ABSTRACT Aging is a risk factor for cardiovascular disease, the leading cause of death worldwide. Cardiac fibrosis harmful result repeated myocardial infarction that increases morbidity and future injury. Interestingly, rates cardiac are different between young aged individuals, as well men women. Here, first time, we identify isolate matrix-bound extracellular vesicles from left ventricles (LVs) or These LV (LVVs) show differences in morphology content these four cohorts. LVVs effects on...
Rapid diagnosis of acute myocardial infarction (AMI) is crucial for optimal patient management.
Abstract Aging is a major risk factor for cardiovascular disease, the leading cause of death worldwide, and numerous other diseases, but mechanisms these aging-related effects remain elusive. Chronic changes in microenvironment paracrine signaling behaviors have been implicated, understudied. Here, first time, we directly compare extracellular vesicles obtained from young aged patients to identify therapeutic or disease-associated agents, isolated heart tissue matrix (TEVs) plasma (PEVs)....
Abstract In this article we review the microfabrication approaches, with a focus on bioprinting and organ-on-chip technologies, used to engineer cardiac tissue. First, give brief introduction heart anatomy physiology, developmental stages of from fetal adulthood. We also information tissue microenvironment, including cells residing in heart, biochemical composition structural organization extracellular matrix, signaling factors playing roles development maturation, their interactions one...
Myocardial Infarction Diagnosis To address the limitations of current myocardial infarction (MI) detection technology, in article 2201330, Pinar Zorlutuna and co-workers develop human heart anoxia reperfusion tissue (HEART) model combined with a near real-time microRNAs (miRNAs) concentration sensor for analysis miRNAs under MI conditions. This provides modular, physiologically relevant tool discovery novel biomarkers as well diagnostic therapeutic approaches.
Aging is one of the inherent risk factors for breast cancer. Although influence age-related cellular alterations on cancer development has been extensively explored, little known about in aging tissue microenvironment, specifically extracellular matrix (ECM). Here, first time literature, we have identified resident bound vesicles (MBVs) within healthy mouse ECM, investigated and compared their characteristics young aged tissues, studied effects these MBVs normal (KTB21) cancerous...