A5085025048- Advancements in Transdermal Drug Delivery
- melanin and skin pigmentation
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Dermatology and Skin Diseases
- Curcumin's Biomedical Applications
- Bee Products Chemical Analysis
- Biochemical Analysis and Sensing Techniques
- Drug Solubulity and Delivery Systems
- Dyeing and Modifying Textile Fibers
- Advanced Drug Delivery Systems
- Silymarin and Mushroom Poisoning
- Silk-based biomaterials and applications
- Toxin Mechanisms and Immunotoxins
- Antifungal resistance and susceptibility
- RNA Interference and Gene Delivery
- Synthesis and bioactivity of alkaloids
- Biosensors and Analytical Detection
- Phenothiazines and Benzothiazines Synthesis and Activities
- Essential Oils and Antimicrobial Activity
- Proteins in Food Systems
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
Mazandaran University of Medical Sciences
2020-2025
Abstract Purposes Calcium channel blockers, such as diltiazem (DLZ), are important drugs for wound repair treatment. This current study used an ultrasonic method to increase the cutaneous delivery of (DLZ) niosomes. Methods The impact cholesterol:surfactant ratio on DLZ-loaded niosome formulations was investigated. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR)...
In the current study, an ultrasonic approach (as green method) was utilized to prepared kojic acid niosome (kojisome) which aimed increase dermal delivery and improving anti-melanogenesis properties. The study's findings demonstrated that increasing cholesterol enhanced mean particle size from 68.333 ± 5.686 nm 325.000 15.099 entrapment efficiency 0% 39.341 4.126% of kojisome. Cholesterol may enhance number rigidity bilayers induced a enhancement efficiency. skin permeability test revealed...
Depression is a serious mental health disorder that can deeply affect person's quality of life, and the importance treatment for depression cannot be overstated. The aim this study to compare ultrasonication procedure as green method thin film hydration technique conventional way preparation niosome increase venlafaxine HCl brain delivery investigate BDNF (Brain-derived neurotrophic factor) gene expression. Both approaches provided well-defined sphere particles; however, (ultrasonication)...
ABSTRACT Introduction Dermatophytosis, a cutaneous fungal infection worldwide, is generally localised to the skin's superficial layers and keratinised structures. Although most agents are susceptible current antifungal drugs available in clinical settings, frequent relapses failures, especially cases due Trichophyton indotineae , have been frequently reported. Therefore, alternative targets therapeutic approaches highly required. In present study, we compared efficacies of terbinafine with...
Background: Trichophyton indotineae terbinafine-resistant infections are emerging in healthy individuals. Luliconazole, an imidazole antifungal that is effective against skin infections, faces challenges due to low water solubility and poor penetration. This study aimed formulate a luliconazole-loaded nanostructured lipid-carrier (NLC) gel Carbopol-based system enhance drug absorption efficacy guinea pig model of dermatophytosis. Methods: Luliconazole-loaded lipid carriers (NLCs) were...
The local treatment of kojic acid (KA) as a tyrosinase inhibitor results in inadequate skin absorption and number side effects. current study aims to maximize KA delivery. To produce KA-hydrogel, 1% was injected into Chitosan/alginate hydrogel. impacts biopolymer proportion on the KA-hydrogel preparations were investigated. Swelling analysis, weight loss differential scanning calorimetry (DSC), electron microscopy (SEM), UV spectroscopy, attenuated total reflectance-Fourier transform...
The possibility of controlling periorbital hyperpigmentation disorders is one the most important research goals in cosmetic preparations. In current investigation, 1% vitamin K (Vit K) was incorporated into a Chitosan/alginate hydrogel which aimed to increase dermal delivery and anti-pigmentation effect. Vit K-hydrogel evaluated using several different tests, including volume expansion/contraction analysis, differential scanning calorimetry (DSC), electron microscopy (SEM), ultraviolet (UV)...
Terbinafine (TER) is a promising candidate medication for the topical treatment of fungal infections. However, its solubility in water and skin permeability are limited. To overcome these limitations, niosome niosomal gel was developed. The impact cholesterol:surfactants on terbinafine incorporated (terbinasome) preparations examined. Differential scanning calorimetry (DSC), photon correlation spectroscopy (PCS), electron microscopy (SEM), attenuated total reflectance-Fourier transform...
Background: The purpose of the current work was to manufacture vitamin A (Vit A) niosome and solid lipid nanoparticle (SLN) using an ultrasonic approach evaluate its effect on wound healing. Methods: nanoparticles were prepared through ultrasonication technique characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM). Further, evaluated for their various parameters such as pH, viscosity, spreadability, stability, in-vitro drug release study, cytotoxicity,...
Purpose: Spironolactone (SPN), which is classified as an anti-androgen, has demonstrated efficacy in treating acne. This study aimed to utilize ultrasonication create a chitosan-coated nano lipid carrier (NLC) for enhancing the delivery of SPN skin and Methods: Various Hydrophilic-Lipophilic Balance (HLB) values were investigated optimize SPN-NLCs. Photon correlation spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), transmission electron...
A hydrogel formulation containing arbutin was developed for use as a topical cosmetic product aimed at enhancing the anti-melanogenesis effect and skin delivery. To develop Arbutin-hydrogel, 1% incorporated into Chitosan/alginate hydrogel. The impacts of biopolymer proportion on arbutin-hydrogel preparations were investigated. Swelling analysis, weight loss differential scanning calorimetry (DSC), electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR)...
Purpose: In the present research, a green technique (an ultrasonic method) was used to synthesize menadione sodium bisulfite (MSB) niosome (Menasome) which is improve dermal delivery and increase anti-melanogenesis activities. Methods: Various cholesterol: surfactant (Chol: Sur) ratios were investigated optimize Menasomes. Photon correlation spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), differential...
Luliconazole (LCZ) is a topical imidazole antifungal agent with broad-spectrum activity. However, LCZ encounters challenges such as low aqueous solubility, skin retention, and penetration, which reduce its dermal bioavailability hinder efficacy in drug delivery. The aim of the present study was to formulate, characterize, evaluate vitro luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against panel resistant fungal strains. LCZ-NLCs were synthesized using modified...
<title>Abstract</title> Luliconazole (LCZ) is a topical imidazole antifungal agent with broad-spectrum activity. However, LCZ faces challenges like low aqueous solubility, skin retention, and penetration, limiting its dermal bioavailability effectiveness in drug delivery. This study aims to formulate, characterize, assess the vitro efficacy of luliconazole-loaded nanostructured lipid carriers (LCZ-NLCs) against resistant fungal strains.<bold> </bold>The LCZ-NLCs were synthesized using...
AbstractIn the present study, an ionic gelation and ultrasonic approach was performed to produce kojic acid (KA) loaded chitosan(CS)/collagen(CN) nanoparticle(NP) (CSCN-NP) which aimed increase dermal delivery anti-pigmentation effect. To optimize CSCN-NP effect of amount CN investigated. The results showed that increasing from 0 500 mg increased mean particle size entrapment efficiency KA-CSCN-NP 266.07 ± 9.30 nm 404.23 9.44 17.37 2.06% 82.34 2.16%, respectively. Differential scanning...
Pain is an unfavorable feeling that generally triggered by endogenous or exogenous harmful stimulation and has a strong emotional impact. The objective of this experimentation was to increase the cutaneous absorption nortriptyline HCl (NOR) encapsulated in niosome (norosomes) produced ultrasonic approach for management antinociceptive anti-inflammatory disorders. Exploring implications cholesterol:surfactant ratio on norosome compositions, study revealed increasing cholesterol significantly...