The COVID-19 outbreak has exerted a great deal of psychological pressure on Iranian health workers and the general population. aim this study was to determine effect pandemic anxiety depression in population.An online cross-sectional conducted for public healthcare Iran using questionnaire comprised demographic questions Hospital Anxiety Depression Scale. Chi-square test univariate multivariate logistic regression models were conducted.Of 2045 participants, 1136 (65.6%) considered have...

Abstract This trial aims to evaluate the effectiveness of adding melatonin treatment protocol hospitalized coronavirus disease 2019 (COVID‐19) patients. was an open‐label, randomized controlled clinical in COVID‐19 Patients were into a arm receiving plus standard care or control alone. The trial's primary endpoint sleep quality examined by Leeds Sleep Evaluation Questionnaire (LSEQ). secondary endpoints symptoms alleviation Day 7, intensive unit admission, 10‐day mortality, white blood cell...

The Sputnik V is a COVID- 19 vaccine developed by the Gamalia institute of epidemiology and microbiology released on August 11, 2020. We provided independent evidence side effects immunogenicity following administration COVID-19 in Iran. In this observational study, healthcare workers who were vaccinated with within February April 2021 evaluated. Among total 13,435 workers, we received 3236 self-declaration reports associated adverse events mean age 39.32 ± 10.19 years old which 38.8% men...

ABSTRACT Background The COVID-19 outbreak has exerted a great deal of psychological pressure on Iranian health workers and the general population. In present study, prevalence anxiety depression symptoms along with related variables in this epidemic were investigated. Method An online cross-sectional study was conducted for public healthcare IRAN using questionnaire comprised demographic questions Hospital Anxiety Depression Scale. Chi square test used to compare categorical variables,...

Effective treatments are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19). This trial aims evaluate sofosbuvir and daclatasvir versus standard care for outpatients with mild COVID-19 infection. was a randomized controlled clinical in COVID-19. Patients were into treatment arm receiving sofosbuvir/daclatasvir plus hydroxychloroquine or control alone. The primary endpoint of symptom alleviation after 7 days follow-up. secondary hospital admission. Fatigue, dyspnoea loss...

Background: One of the most critical health issues in world is COVID-19 pandemic from Coronaviridae family. There a lack knowledge regarding disease, and liver involvement controversial. Objectives: We aimed to analyze laboratory investigations patients focusing on enzymes association with outcomes. Methods: enrolled 93 referring Mazandaran University Medical Sciences' hospitals 186 people normal population Tabari Cohort. The tests included CBC, Aspartate Aminotransferase (AST), Alanine...

Neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte (LMR) and platelet-lymphocyte (PLR) have a prognostic value in several types of diseases such as cancers they vary different races. So, we aimed to evaluate the normal range these markers among healthy people determine Iranian population.In present study, cross-sectional data population-based cohort study named "Tabari study" was utilized. In first phase Tabari cohort, 10255 participants aged 35-70 years from urban rural areas Sari,...

Toxoplasma gondii is a ubiquitous parasitic protozoan that can cause neurological and psychiatric disorders, potentially impacting human emotional behavior. This study aimed to explore serological molecular evidence of T. infection in opioid abusers northern Iran. In this case-control study, who were referred substance abuse rehabilitation centers Mazandaran Province, Iran, enrolled. Blood samples collected from the participants perform assay detect IgG IgM antibodies. A polymerase chain...

Up-regulation of immune checkpoint ligands and secretion soluble factors in the tumor microenvironment led to survival cancerous plasma cells bone marrow milieu. Therefore, we investigate relationship between inhibition c-Kit receptor, AKT, NF-κB signaling pathways regulation escape mechanisms multiple myeloma. The U266B1 cell line was treated with Masitinib as a receptor inhibitor, Perifosine AKT Bortezomib inhibitor either single or combined form. Apoptosis viability were evaluated using...

Background: Anemia is a common blood disorder in developing countries and associated with diseases such as diabetes, well cardiovascular pulmonary diseases. This study aimed to investigate the relationship between anemia anthropometric profiles Tabari cohort population. Study Design: A case-control study. Methods: In this study, we used subset of data collected during first phase (TCS). All participants who had were included case group (1352 individuals) using census method. The control...

The present study aimed to compare the complete blood count (CBC) indices between COVID-19 patients and control group, assess relationship of these with prognosis.

This study was aimed at preparing and characterising kojic acid nanostructured lipid carriers (KA-NLCs) for delivery to skin. KA-NLCs were prepared using high-speed homogenization followed by ultra-probe sonication method. optimized glyceryl mono-stearate (GMS) cholesterol (Chol) as solid excipients, oleic (OA) liquid excipient, span 60 (SP 60) Tween 20 (Tw 20) co-emulsifiers. For formulation (KA-NLC3), values of particle size, encapsulation efficiency, drug loading, polydispersity index...

Abstract Purposes Reactive oxygen species production is harmful to human’s health. The presence of antioxidants in the body may help diminish reactive species. Trans -ferulic acid a good antioxidant, but its low water solubility excludes utilization. study aims explore whether vesicular drug delivery could be way overcome poor absorption trans hence improving antimicrobial efficiency and antioxidant effect. Methods Niosomal vesicles containing were prepared by film hydration method. obtained...

Ongoing mutations in the coronavirus family, especially beta-coronaviruses, raise new concerns about possibility of unexpected outbreaks. Therefore, it is crucial to explore alternative treatments reduce impact potential future strains until vaccines can be developed. A promising approach combat virus target its conserved parts such as nucleocapsid, via repurposing existing drugs. The this explored here find a anti-nucleocapsid compound these viruses. 3D models N- and C-terminal domains...

A rapid outbreak of novel coronavirus, coronavirus disease-2019 (COVID-19), has made it a global pandemic. This study focused on the possible association between lymphopenia and computed tomography (CT) scan features COVID-19 patient mortality. The clinical data 596 patients were collected from February 2020 to September 2020. patients' serological survey CT retrospectively explored. median age was 56.7 ± 16.4 years old. Lung involvement more than 50% in 214 (35.9%). average blood lymphocyte...

Introduction: Gastric cancer is one of the common causes cancer-related death in world. Neurotransmitters have recently been related to proliferation cells, but role neurotransmitters progression gastric still unexplored. The cross-talk between nervous system and immune cells through serotonin its receptors tumor microenvironment can impact progress. Our purpose expose probable changes receptors, acetylcholinesterase, monoamine oxidase A gene expression cancer. Methods: Transcript (5-HTR2A,...