A5065886766- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Antifungal resistance and susceptibility
- HER2/EGFR in Cancer Research
- Toxoplasma gondii Research Studies
- Glycosylation and Glycoproteins Research
- Helicobacter pylori-related gastroenterology studies
- Herpesvirus Infections and Treatments
- Plant Pathogens and Fungal Diseases
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- vaccines and immunoinformatics approaches
- Cancer-related molecular mechanisms research
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Nail Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Probiotics and Fermented Foods
- Fungal Biology and Applications
- Bacteriophages and microbial interactions
Mazandaran University of Medical Sciences
2016-2025
University of Mazandaran
2021-2022
Ferdowsi University of Mashhad
2015-2021
Tehran University of Medical Sciences
2020-2021
Cancer Research Center
2020
University of Sistan and Baluchestan
2020
Imam Reza Hospital
2020
Czech Academy of Sciences, Institute of Biotechnology
2015
Shiraz University
2012
Purpose Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate have been proposed COVID-19. However, at present, there is no consensus on the best diagnostic approach to in infected patients. Moreover, it not clear whether such tools would apply other potentially pandemic pathogens therefore of use as stockpile future preparedness. Methods We conducted a multi-cohort observational study...
Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the susceptibility profiles in Iranian isolates these two species.A total 96 45 were subjected to molecular typing by ribosomal ITS region. Antifungal for terbinafine, griseofulvin, clotrimazole, efinaconazole, luliconazole, amorolfine ciclopirox obtained CLSI broth microdilution method. The squalene epoxidase (SQLE) gene was...
Malignant melanoma is a devastating disease. Because of its aggressiveness, it also serves as model tumor for investigating novel therapeutic avenues. In recent years, scientific evidence has shown that cold atmospheric plasma (CAP) might be promising modality in cancer therapy. this study, we aimed to evaluate the effect CAP generated by an argon jet alone or combination with dacarbazine (DAC) on cells vitro and vivo. The effects inducing lipid peroxidation nitric oxide production were...
Abstract Background Aedes aegypti is the main vector of arboviral diseases worldwide. The species invaded and became established in southern Iran 2020. Insecticide-based interventions are primarily used for its control. With insecticide resistance widespread, knowledge mechanisms vital informed deployment insecticidal interventions, but information from Iranian Ae. lacking. Methods Fifty-six specimens were collected port city Bandar Lengeh Hormozgan Province South 2020 screened kdr...
Background: To date, no specific vaccine or drug has been proven to be effective against SARS-CoV-2 infection. Therefore, we implemented an immunoinformatic approach design efficient multi-epitopes SARS-CoV-2. Results: The designed-vaccine construct consists of several immunodominant epitopes from structural proteins spike, nucleocapsid, membrane, and envelope. These peptides promote cellular humoral immunity interferon-gamma responses. Also, these have a high antigenic capacity are not...
Background and Objectives: During the coronavirus pandemic, overuse of antibiotics to reduce coinfections mor- tality may be contributing rise antimicrobial resistance. In this study, we aim investigate antibiotic resistance changes Acinetobacter baumannii post-COVID-19 pandemic in Northern Iran. Materials Methods: The current study is a cross-sectional study. Between 2022 2023, 2190 clinical samples were collected from patients with healthcare-associated infections (HAIs) at four hospitals...
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that have vital roles in activating further immune responses. However, due to their tumor-induced diversity, we decided examine ILCs, T cells, and the associated cytokines mouse models of breast cancer. 4T1 MC4-L2 were used induce triple-negative hormone-receptor-positive cancer, respectively. Tumor tissue was resected at early late stages tumor growth for analysis. Total RNA extracted Real-Time PCR analyze expression IFN-γ, IL-4,...
Ongoing mutations in the coronavirus family, especially beta-coronaviruses, raise new concerns about possibility of unexpected outbreaks. Therefore, it is crucial to explore alternative treatments reduce impact potential future strains until vaccines can be developed. A promising approach combat virus target its conserved parts such as nucleocapsid, via repurposing existing drugs. The this explored here find a anti-nucleocapsid compound these viruses. 3D models N- and C-terminal domains...
Insecticide resistance of Anopheles stephensi, the main malaria vector in eastern Afghanistan, has been reported previously. This study describes biochemical and molecular mechanisms to facilitate effective control insecticide management.Mosquito larvae were collected from provinces Kunar, Laghman Nangarhar 2014 2017. The susceptibility reared 3-4 days old adults was tested with deltamethrin 0.05%, bendiocarb 0.1%, malathion 5%, permethrin 0.75% DDT 4%. Cytochrome P450 content general...
Aspergillus flavus is one of the most important agents invasive and non-invasive aspergillosis, especially in tropical subtropical regions world, including Iran. oryzae closely related to A. flavus, it known for its economic importance traditional fermentation industries. Reports infection due are scarce. Several studies reported that differentiating these two species clinical laboratories not possible using MALDI-TOF or by targeting fungal barcode genes, such as Internal Transcribed Spacer...
Summary Toxoplasma gondii can cause severe and even fatal disease in human beings animals. Effective vaccines may contribute to control toxoplasmosis. GRA 14, a novel secreted dense granule protein of T. gondii, has been proposed as vaccine candidate due its intervacuolar transport unique topology the parasitophorous vacuole membrane. In this study, we constructed DNA encoding 14 . BALB /c mice were immunized intramuscularly three times at 2 week intervals challenged with RH strain 5 weeks...
Aspergillus clavatus is a common environmental species known to cause occupational allergic disease in grain handlers. We have recently observed azole-resistant isolates of this fungus as onychomycosis. To further characterize the resistance, genes encoding 14 α-sterol demethylase enzyme (cyp51A and cyp51B) were characterized analyzed 9 ITC-susceptible 6 with high minimum inhibitory concentrations (MICs) clinical (nail sputum) A. strains. found that six itraconazole MIC >16 mg/L demonstrated...