A5050186562- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 and Mental Health
- Bacteriophages and microbial interactions
- Dermatological diseases and infestations
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- Surgical site infection prevention
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- interferon and immune responses
- Urinary Tract Infections Management
- Ginger and Zingiberaceae research
- Adolescent Sexual and Reproductive Health
- Parasitic Diseases Research and Treatment
Mazandaran University of Medical Sciences
2018-2024
Sina Hospital
2023
Islamic Azad University Sari Branch
2022
Shiraz University of Medical Sciences
2021
Ahvaz Jundishapur University of Medical Sciences
2014-2017
Purpose Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate have been proposed COVID-19. However, at present, there is no consensus on the best diagnostic approach to in infected patients. Moreover, it not clear whether such tools would apply other potentially pandemic pathogens therefore of use as stockpile future preparedness. Methods We conducted a multi-cohort observational study...
Context: Within only 30 days after the first announcement of infection with "SARS-CoV-2" in Wuhan, it spread to more than 20 countries and become a pandemic by WHO as "high alarming level infection" 136,343 involved cases all over world. Methods: To uncover about probable gastrointestinal transmission its clinical manifestations, we reviewed research publications keywords including: "COVID-19", "SARS-CoV-2", "Coronavirus", "outbreak", "ARAS-CoV" Medline, Scopus, Google Scholar well news...
Effective treatments are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19). This trial aims evaluate sofosbuvir and daclatasvir versus standard care for outpatients with mild COVID-19 infection. was a randomized controlled clinical in COVID-19. Patients were into treatment arm receiving sofosbuvir/daclatasvir plus hydroxychloroquine or control alone. The primary endpoint of symptom alleviation after 7 days follow-up. secondary hospital admission. Fatigue, dyspnoea loss...
Background: One of the most critical health issues in world is COVID-19 pandemic from Coronaviridae family. There a lack knowledge regarding disease, and liver involvement controversial. Objectives: We aimed to analyze laboratory investigations patients focusing on enzymes association with outcomes. Methods: enrolled 93 referring Mazandaran University Medical Sciences' hospitals 186 people normal population Tabari Cohort. The tests included CBC, Aspartate Aminotransferase (AST), Alanine...
Ongoing mutations in the coronavirus family, especially beta-coronaviruses, raise new concerns about possibility of unexpected outbreaks. Therefore, it is crucial to explore alternative treatments reduce impact potential future strains until vaccines can be developed. A promising approach combat virus target its conserved parts such as nucleocapsid, via repurposing existing drugs. The this explored here find a anti-nucleocapsid compound these viruses. 3D models N- and C-terminal domains...
Many of the treatment regimens available for hepatitis C include sofosbuvir. Unfortunately, sofosbuvir has not been recommended use in patients with severe renal impairment leaving these group very few options. Nevertheless, there are many reports which have treated sofosbuvir-containing regiments without important adverse events. This study aims at determining safety and effectiveness a sofosbuvir-based impairment, including those on hemodialysis.We enrolled subjects estimated glomerular...
The combination of sofosbuvir and daclatasvir is a potent, pangenotypic regimen suitable for mass-scale hepatitis C treatment, especially in resource-limited countries where newer, expensive combinations are not available. This has been widely tested on genotype 4. However, Phase III trials this other genotypes have cost prohibitive. With the introduction generic, low-cost daclatasvir, large-scale studies now possible.Sofosbuvir at 400 mg 60 were coformulated into fixed-dose (FDC) tablet...
Ivermectin which was widely considered as a potential treatment for COVID-19, showed uncertain clinical benefit in many trials. Performing large-scale trials to evaluate the effectiveness of this drug midst pandemic, while difficult, has been urgently needed.We performed two large multicenter randomized, double-blind, placebo-controlled evaluating ivermectin treating inpatients and outpatients with COVID-19 infection. The intervention group received ivermectin, 0.4mg/kg body weight per day 3...
Inhalation phage therapy is proposed as a replacement approach for antibiotics in the treatment of pulmonary bacterial infections. This study investigates on pneumonia patients with moderate to severe COVID-19 via inhalation route. In this double-blind clinical trial, 60 positive hospitalized three central Mazandaran hospitals were chosen and randomly divided into two intervention control groups. Standard country protocol drugs plus 10 mL suspension every 12 h mesh nebulizer was prescribed 7...
Despite the effectiveness of prophylactic antimicrobials to prevent surgical site infection use antibiotic prophylaxis is often inappropriate.The current study aimed determine pattern in a teaching hospital affiliated Jundishapur University Medical Sciences, Ahvaz, Iran.The descriptive included 8586 patients who received antibiotics before surgery from April 2011 March 2012, Razi Hospital Sciences. Indications for use, proper or inappropriate antibiotics, an combination dosage and length...
Abstract The Outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in late 2019 China and many other countries around the world necessitate immediate action to develop new drugs against virus. Repurposing existing for targets is a fast, safe unexpansive approach this goal. Studies have shown that naproxen could specifically interact with RNA binding domain nueclporteins viruses such as influenza Therefore, study aimed evaluate properties nucleocapsid protein...
Background: Lectin pathway mediates complement activation, which is activated by many microorganisms. This study aimed at determining the serum levels of mannose-binding lectin (MBL) in patients with pulmonary tuberculosis, assessing its relationship to antiuberculosis treatment response, and comparing them a control group. Methods: cross-sectional was conducted on tuberculosis during 2012 2013 South West Iran. PPD-ST-negative individuals were selected as controls from healthy relatives...
Context: Burns and associated injuries are considered as the most severe types of trauma leading to multiple disabilities. Hence, obtaining information from burn-related demographic variables is also particular importance. The consequences burn include mortality, high hospital costs, mental emotional health problems.Aims: current study was conducted determine affecting mortality rate among patients in Burn Center Mazandaran University Medical Sciences (Sari, Iran).Settings Design: This a...
Hemodialysis (HD) is one of the most common causes blood-borne infections. In order to prevent viral hepatitis and confront with virus on next step, health providers specify infected patients by screening vaccination. This study designed investigate prevalence Hepatitis B (HBV) C (HCV) infections in HD Mazandaran, Iran.The medical records 216 referred hemodialysis centers were evaluated this cross-sectional between 2019 2020. The collected data was analyzed using t-test Chi-square.Among...
BackgroundWe planned this study to evaluate the effects of coenzyme Q10 (CoQ10), a substance with known on immune system, occurrence opportunistic infections and CD4+ T-cell count HIV-infected patients as markers their immunologic status.MethodsThis was parallel, double-blind, placebo-controlled, randomized clinical trial in adult (>18 years old) HIV infection antiretroviral therapy (ART) referring Ahvaz Behavioral Diseases Consultation Center. The intervention group given CoQ10, one 200 mg...
Background: Influenza A (H1N1) is a highly contagious virus derived from one of the several types swine influenza strains, called H3N2. It can be transmitted person to through sneezing or coughing. In 2009, pandemic emerged in some regions. This study aimed at investigating mortality incidence associated with 2009 H1N1 by meta-analysis 21 countries WHO Eastern Mediterranean Region. Materials and Methods: Literature search was carried out international databases. order increase sensitivity,...
Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syndrome (ARDS) worldwide in late 2019. Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose diseases; therefore, this study aimed analyze parameters patients with COVID-19. Methods: cross-sectional study, data 2563 COVID-19 admitted hospitals affiliated Mazandaran University Medical Sciences were extracted from hospital...
Background and Purpose: Several evidences have shown some synergistic effect of diabetes co-morbidity on the tuberculosis (TB) treatment results, while other studies not found such associations. This study aimed to investigate relationship between TB-diabetes outcomes TB treatment. Materials Methods: The research population in this case control were patients with smear positive tuberculosis. cases 158 selected by consensus method, controls 316 randomly from without diabetes. Results:...