A5010894628- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Dental materials and restorations
- Dental Research and COVID-19
- Brucella: diagnosis, epidemiology, treatment
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Drug-Induced Hepatotoxicity and Protection
- Leptospirosis research and findings
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Antibiotic Use and Resistance
- Dental Anxiety and Anesthesia Techniques
- Vaccine Coverage and Hesitancy
- Diagnosis and treatment of tuberculosis
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
- Galectins and Cancer Biology
- Infectious Encephalopathies and Encephalitis
- HIV Research and Treatment
- Nosocomial Infections in ICU
- HIV/AIDS drug development and treatment
- Burkholderia infections and melioidosis
Mazandaran University of Medical Sciences
2014-2024
Razi Hospital
2012-2024
Arak University
2021
Ahvaz Jundishapur University of Medical Sciences
2013-2020
Kermanshah University of Medical Sciences
2012-2018
University of Tennessee Health Science Center
2017
McGill University
2017
University of Tehran
2008-2016
Georgetown University
2016
Georgetown University Medical Center
2016
Continued advances in metabolic engineering are increasing the number of small molecules being targeted for microbial production. Pathway yields and productivities, however, often suboptimal, strain improvement remains a persistent challenge given that majority difficult to screen their biosynthesis does not improve host fitness. In this work, we have developed generalized approach or select improved small-molecule using transcription factor-based biosensors. Using tetracycline resistance...
In this study, we genotyped parasites from the fecal specimens of sporadic cryptosporidiosis cases in British Columbia 1995 to 1999. Genotyping was conducted by polymerase chain amplification internal transcribed spacer region, a hypervariable region 18S rRNA gene and Cryptosporidium oocyst wall protein gene. Subsequent analysis restriction fragment length polymorphism DNA sequencing. We identified two new genotypes humans. One these has been found recently deer New York state. The other...
Abstract Background New therapeutic options are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19). Repurposing existing pharmaceuticals provides an immediate treatment opportunity. We assessed efficacy of sofosbuvir and daclatasvir with ribavirin for treating patients COVID-19. Methods This was a single-centre, randomized controlled trial in adults moderate COVID-19 admitted Ghaem Shahr Razi Hospital Mazandaran Province, Iran. Patients were randomly assigned 400 mg...
The Sputnik V is a COVID- 19 vaccine developed by the Gamalia institute of epidemiology and microbiology released on August 11, 2020. We provided independent evidence side effects immunogenicity following administration COVID-19 in Iran. In this observational study, healthcare workers who were vaccinated with within February April 2021 evaluated. Among total 13,435 workers, we received 3236 self-declaration reports associated adverse events mean age 39.32 ± 10.19 years old which 38.8% men...
Background and purpose Intracerebral hemorrhage ( ICH ) is a devastating cerebrovascular disorder with high morbidity mortality. Minocycline matrix metalloproteinase‐9 MMP ‐9) inhibitor that may attenuate secondary mechanisms of injury in . The feasibility safety minocycline patients were evaluated pilot, double‐blinded, placebo‐controlled randomized clinical trial. Methods Patients acute onset (<12 h from symptom onset) small initial hematoma volume (<30 ml) to high‐dose (10 mg/kg)...
An integrated nano-electromechanical chip (NELMEC) has been developed for the label-free distinguishing of both epithelial and mesenchymal circulating tumor cells (ECTCs MCTCs, respectively) from white blood (WBCs). This nanoelectronic microfluidic fabricated by silicon micromachining can trap large single (>12 µm) at opening analysis microchannel arrays. The nature captured is detected using nanograss (SiNG) electrodes patterned entrance channels. There an observable difference between...
Background . Mycobacterium tuberculosis ( M.TB ) causes a wide spectrum of clinical diseases. The prevalence TB is different in various parts Iran and throughout the world. present study aimed to determine epidemiology paraclinical findings TB. Methods A cross-sectional was conducted from 2008 2013. Patient demographic, clinical, radiologic characteristics, picked up patient’s files, were collected using standard questionnaire format. Data entered analyzed SPSS version 16 statistical...
ABSTRACT Animal models are essential to study novel antiretroviral drugs, resistance-associated mutations (RAMs), and treatment strategies. Bictegravir (BIC) is a potent integrase strand transfer inhibitor (INSTI) that has shown promising results against HIV-1 infection in vitro vivo clinical isolates with resistance INSTIs. BIC higher genetic barrier the development of than two clinically approved INSTIs, termed raltegravir elvitegravir. Another INSTI, dolutegravir (DTG) also possesses high...
Abstract Intestinal epithelial cell damage caused by SARS-CoV-2 infection was thought to be associated with gastrointestinal symptoms and decreased fecal consistency. The association of the COVID-19-mediated inflammatory response triggered immune system investigated in this paper. inflammation marker calprotectin along serum other markers were measured COVID-19 cases without GI manifestations as well healthy individuals. Analyses performed compare patient subgroups controls examine...
Background . Herpes zoster infection is a painful worldwide disease. Inappropriate and delayed treatment causes prolongation of the disease with debilitating symptoms postherpetic neuralgia. Method A cross-sectional study evaluated shingles cases admitted in teaching hospital one-year followup north Iran from 2007 to 2013. Results From 132 patients, 60.4% were male. Head neck involvement occurred 78 people (59.1%), thoracoabdominal region 37 (28%), extremities 16 (12.1%), one case (0.8%) got...
Ivermectin which was widely considered as a potential treatment for COVID-19, showed uncertain clinical benefit in many trials. Performing large-scale trials to evaluate the effectiveness of this drug midst pandemic, while difficult, has been urgently needed.We performed two large multicenter randomized, double-blind, placebo-controlled evaluating ivermectin treating inpatients and outpatients with COVID-19 infection. The intervention group received ivermectin, 0.4mg/kg body weight per day 3...
Inhalation phage therapy is proposed as a replacement approach for antibiotics in the treatment of pulmonary bacterial infections. This study investigates on pneumonia patients with moderate to severe COVID-19 via inhalation route. In this double-blind clinical trial, 60 positive hospitalized three central Mazandaran hospitals were chosen and randomly divided into two intervention control groups. Standard country protocol drugs plus 10 mL suspension every 12 h mesh nebulizer was prescribed 7...
Abstract Background The aim of this study was to establish the prevalence lipodystrophy and its association cumulative exposure antiretroviral drugs. Method We conducted a cross sectional in all HIV- infected patients attending HIV clinic Centre hospitalier universitaire de Montréal (CHUM) with DEXA scan. Lipodystrophy defined as trunk/limb fat ratio ≥ 1.5. Association between (measured years use) (coded continuous variable) assessed using univariate multivariate linear regression for each...
The most common dental disease in childhood is caries. This study was carried out to recognize the components of saliva which are protective factors children evaluate and predict caries susceptible resistant individuals. Unstimulated whole obtained from 75 aged 3-5 years. They divided into three groups: decayed missing filled teeth (dmft) > 6 (severe caries), 1 < dmft (moderate (caries free). assayed by biochemical methods determine salivary calcium, inorganic phosphate, alkaline...
Brucellosis, a zoonotic disease caused by Brucella species, poses significant global health concern. Among its diverse clinical manifestations, neurobrucellosis remains an infrequent yet debilitating complication. Here, we present rare case of with unusual presentations in 45-year-old woman. The patient's course included progressive lower extremity weakness, muscle wasting, and double vision, prompting comprehensive diagnostic evaluation. Notable findings polyneuropathy, elevated brucella...
Introduction: Leptospirosis is an important zoonotic disease in paddy field with 29.5% prevalence rate Mazandaran province and 4% to 52% mortality among hospitalized patients. Prevention strategy for the control of this disease. This study aimed compare prophylactic effect azithromycin versus doxycycline against leptospirosis endemic area north Iran.
 Methodology: In randomized double-blind placebo-controlled trial, workers (n = 187) were receive (500mg weekly), (200 mg weekly) or...
Background . Previous studies that assessed the role of birth weight and gestational age in risk asthma have been conflicting. Objectives To examine association between symptoms asthma. Patients Methods Subjects were 6656 school children ages 6-7 13-14 years from urban districts Mazandaran, Iran. ISAAC questionnaires used. Results There was an increased “wheeze ever” both groups with under 2.5 kg all subgroups low (LBW). Birth more than 3.5 associated lower “severe asthma” group years. With...
Background: Human immunodeficiency virus (HIV) infected patients are also frequently exposed to the hepatitis B (HBV), due common routes of transmission, therefore, prevention results in decreased complications disease. Objectives: Since immune response HIV vaccination is less robust than that found healthy individuals, this study aimed evaluate effect a levamisole adjuvant on increasing response. Patients and Methods: In study, 89 patients, without history HBV infection or vaccination, were...
Abstract Specific immunoadsorption of blood group antibodies by synthetic antigens immobilized on support matrices in the peri‐transplantation period provides a promising solution to hyperacute rejection risk following ABO‐incompatible transplantation. In this study, we investigated binding interactions between anti‐A and A trisaccharide conjugated with polyacrylamide different molecular weights (30 1000 kDa). The glycopolymers were equipped biotin tags deposited streptavidin‐coated sensor...