A5006016130- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Immunotherapy and Immune Responses
- Lanthanide and Transition Metal Complexes
- DNA Repair Mechanisms
- Medical Imaging Techniques and Applications
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Orthopedic Infections and Treatments
- Hematological disorders and diagnostics
- Streptococcal Infections and Treatments
- Bone health and osteoporosis research
King's College London
2019-2023
Queen Mary University of London
2023
Universidad de Londres
2023
The London College
2023
St Thomas' Hospital
2019-2023
Transnational Press London
2019
Calcium minerals such as hydroxyapatite (HAp) can be detected noninvasively in vivo using nuclear imaging agents [18F]NaF (available from cyclotrons), for positron emission tomography (PET) and 99mTc-radiolabeled bisphosphonates (BP; available 99mTc generators single photon computed (SPECT) or scintigraphy). These two types of allow detection bone metastases (based on the presence HAp) vascular calcification lesions (that contain HAp other calcium minerals). With aim developing a...
Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentrations and their high affinities for oxophilic trivalent metal ions have led to development new applications as bifunctional chelators the radiometal gallium-68 (68Ga). THP-peptide bioconjugates rapidly quantitatively 68Ga room temperature, neutral pH, micromolar ligand concentrations, making them amenable kit-based radiosynthesis of PET radiopharmaceuticals. With aim produce an...
Radiolabelled bisphosphonates (BPs) and [18F]NaF (18F-fluoride) are the two types of radiotracers available to image calcium mineral (e.g. bone), yet only has been widely explored for non-invasive molecular imaging extraosseous calcification (EC) using positron emission tomography (PET) imaging. These bind deposits via different mechanisms, with BPs chelating ions thus being non-selective, selective hydroxyapatite (HAp) which is main component bone mineral. Considering that composition EC...
Radiolabelled lipophilic cations could potentially be used to non-invasively image mitochondrial dysfunction in cardiovascular disease, building on their current role as perfusion imaging agents. We have synthesised and radiolabelled two series of DO2A-based radiotracers, with bistriarylphosphonium- bisaryl-functionalisation respectively, gallium-68 form cations. Both sets tracers radiolabel over 90% RCP, although the kinetic/thermodynamic pairs species upon gallium chelation that can...
Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and paramagnetic MRI contrast agents. The affinity of for lipid bilayers also makes them candidates cell/liposome labelling. We hypothesised that metalation with the positron emission tomography (PET) radionuclide
Abstract The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means assess cellular functional deficits in vivo are being made available such as total-body positron emission tomography (PET) radiotracers long half-lives. Here, we determined radiolabeled human isolated from young old individuals zirconium-89 ( 89 Zr) assessed their biological status vitro distribution . Methods Fresh cryopreserved were labelled varying activities [...
Abstract Background The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means assess cellular functional deficits in vivo are being made available such as total-body positron emission tomography (PET) radiotracers long half-lives. Here, we determined radiolabeled human isolated from young old individuals zirconium-89 ( 89 Zr) assessed their biological status vitro distribution . Results Fresh cryopreserved showed no difference be...
Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and paramagnetic MRI contrast agents. The affinity of for lipid bilayers also makes them candidates cell/liposome labelling. We hypothesised that metalation with the positron emission tomography (PET) radionuclide 52Mn (t1/2 = 5.6 d) would allow long-term in vivo biodistribution studies Mn-porphyrins well a method to label track cells/liposomes, but methods fast...
Abstract Radiolabelled bisphosphonates (BPs) and [ 18 F]NaF ( F-fluoride) are the two types of radiotracers available to image calcium mineral in vivo (e.g. bone), yet only has been widely explored for non-invasive molecular imaging extraosseous calcification (EC) using highly sensitive nuclear technique positron emission tomography (PET). These bind deposits via different mechanisms, with BPs chelating ions thus being non-selective, selective hydroxyapatite (HAp) which is main component...