A5101768970- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Hepatitis C virus research
- Bacteriophages and microbial interactions
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Mathematical and Theoretical Epidemiology and Ecology Models
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Polyomavirus and related diseases
- Machine Learning in Healthcare
- Plant Virus Research Studies
- Dengue and Mosquito Control Research
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- T-cell and Retrovirus Studies
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- RNA and protein synthesis mechanisms
Gansu Provincial Center for Disease Control and Prevention
2016-2025
Fujian Medical University
2014-2025
Education Department of Fujian Province
2017-2025
Center for Disease Control
2008-2022
Southeast University
2020
To enhance the personal immunity to COVID-19, a third booster dose of inactivated COVID-19 vaccines program campaign was implemented in China. Our study endeavored compare dynamics neutralizing antibodies generated by four distinct against three kinds live SARS-CoV-2 virus (wild-type, Delta AY.23, and Omicron BA5.2). This cohort involved 320 healthy individuals, who were randomly assigned groups, receive boosters with vaccine (COVac BIBP), adenovirus type-5-vectored (Convidecia), recombinant...
Hepatitis C virus (HCV) is a bloodborne that causes both acute and chronic hepatitis with the severity from mild illness to liver cirrhosis cancer. As one of major infectious diseases in China, monthly surveillance data Fujian Provincial Center for Disease Control Prevention shows increasing tendency 2004 2011, stable 2012 2016, declining 2017 2022. The 2004-2022 HCV infection Province affected by nation-wide main control measures Chinese government, because no are modified 2020 2022 during...
The purpose of this study was to analyze the epidemiological characteristics and spatial-temporal distribution hepatitis C in Fujian Province, China, from 2015 2022, provide reference for risk identification, early warning prevention control measures Province. incidence data Province 2022 were collected China Information System Disease Control Prevention. Descriptive epidemiology method JRP 4.9.1.0 software used 2022. ArcGIS 10.8 spatial autocorrelation analysis reported C, SaTScan 10.1.3...
Gut microbiota and blood metabolites play crucial roles in the progression outcomes of COVID-19, but causal relationships mechanisms remain unclear. Our aim is to use two-sample Mendelian randomization (MR) explore between gut microbiota, COVID-19 susceptibility, potential mediating metabolites. We utilized summary statistics from largest genome-wide association studies (GWAS) date on (n = 18,340), 115,078), susceptibility (cases n 60,176 controls 1310,725 Host Genetics Initiative...
A vector–host model of dengue with multiple stages and independent fluctuations is investigated in this paper. Firstly, the existence uniqueness positive solution are shown by contradiction. When death rates aquatic mosquitoes, adult human beings respectively control intensities white noises, if R0s>1, then persistence mean for both infective mosquitoes derived. R0s>1 valid, stationary distribution derived through constructing several appropriate Lyapunov functions. If noises...
Avian influenza A (H5N6) virus poses a great threat to the human health since it is capable cross species barrier and infect humans. Although infections are believed largely originate from poultry contaminations, transmissibility unclear only limited information was available on environment especially in Fujian Province.A total of 4901 environmental samples were collected tested for Influenza Virus (AIV) six cities Province through Surveillance System 2013 2017. Two patient-related taken...
Abstract This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data H7N9 their close contacts were obtained through interviews reviews medical records. Of four patients these clusters, had mild symptoms, one severe died. Three a history exposure live poultry or contaminated environments. The complete genome sequences viruses same cluster highly...
Dengue fever (DF) is a vector-borne disease and tremendous socioeconomic burden on tropical subtropical countries worldwide. To explore the characteristics of DF epidemic in Fujian province, information cases during 2004-2014 was collected analyzed. The complete E genes 48 viral isolates were amplified sequenced for phylogenetic analysis. A total 733 reported, which 612 (83.5%) occurred peak period from August to October. Additionally, 76% (190/250) imported originated Southeast Asia...
Abstract Background Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016‐2017 epidemic wave of viruses in China. We report a infection with HPAI H7N9 six environmental isolates Fujian Province, Methods Environmental surveillance was conducted live poultry markets farms Fujian, Clinical epidemiologic data samples were collected. Real‐time RT‐PCRs for each sample, H7‐positive isolated using embryonated chicken eggs. Full genomes obtained by...
We developed a high-throughput bead-based suspension array for simultaneous detection of 20 respiratory tract pathogens in clinical specimens. Pathogen-specific genes were amplified and hybridized to probes coupled carboxyl-encoded microspheres. Fluorescence intensities generated via the binding phycoerythrin-conjugated streptavidin with biotin-labeled targets measured by Luminex 100 system. The detected bacteria significantly higher number samples compared conventional culture. There was no...
To study the molecular epidemiology of hand-foot-mounth disease (HFMD) associated Coxsackievirus A10 (Cox A10) identified in Fujian province.A total 1 525 specimens from non-EV71 non-Cox A16 HFMD patients were collected during 2011-2014. Isolated virus strains and sub-typed. Full-length coding regions for VP1 gene predominant serotype Cox isolates amplified sequenced.Among 407 cases confirmed by isolation subtyping, 103 (25.3%) caused A10, accounting 11.0%, 6.0%, 18.4% 9.2% among...
Objective In this study, we tested for the presence of four human coronaviruses (HCoVs) in children with respiratory tract disease Fuzhou, Fujian, China. Methods Nasopharyngeal aspirates were collected from Nov, 2007 to Jan, 2015. A total 266 clinical samples HCoVs using reverse-transcription polymerase chain reaction (RT-PCR). The positive products sequenced and compared those GenBank by BLAST. then HCoV-HKU1 HCoV-NL63 RT-PCR method . We 440 bp pol gene sequence 8 HCoV isolates China...
Objective To understand the epidemiological and virological features of influenza B viruses difference between vaccine strains epidemic strains, antigenic genetic characteristics on hemagglutinin (HA) gene circulating in Fujian during 2010-2015. Methods The representative were selected randomly according to lineage isolated from network laboratory Fujian, 2010-2015. Viral RNA was extracted fragments amplified by reverse transcription polymerase chain reaction (RT-PCR ) PCR products...
Objective To provide effective reference of laboratory detection and prevention-control in avian influenza epidemic via analyzing the result first case infected H5N6 virus Fujian province. Methods The viral RNA was extracted from patient’s throat swab specimens surrounding environment, detected by real-time RT-PCR. The gene sequences HA NA segments were obtained RT-PCR sequencing, evolution characteristics elementarily analyzed bioinformatics. Results The confirmed swab, termed...
Objective To investigate the genetic characteristics and mutations in hemagglutinin (HA) genes of influenza A subtype H3N2 viruses isolated Fujian province during 2014—2016. Methods HA gene fragments 44 randomly selected (H3N2) were amplified by RT-PCR then sequenced Sanger sequencing. Obtained sequences analyzed bioinformatics software online websites. Results Pair-wise similarity among HA strains was between 97.3%-100.0% at nucleotide level. The average variations epidemic...