A5026271884- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanopore and Nanochannel Transport Studies
Canada's Michael Smith Genome Sciences Centre
2024
University of British Columbia
2024
McGill University
2021
Nanoparticles are a promising solution for delivery of wide range medicines and vaccines. Optimizing their design depends on being able to resolve, understand, predict biophysical therapeutic properties, as function parameters. While existing tools have made great progress, gaps in understanding remain because the inability make detailed measurements multiple correlated properties. Typically, an average measurement is across heterogeneous population, obscuring potentially important...
Lipid nanoparticles (LNPs) have proven to be promising delivery vehicles for RNA-based vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic lipids that undergo protonation/deprotonation response buffer pH changes. These are typically formulated using a rapid mixing technique at low pH, followed by return physiological triggers LNP-LNP fusion. A detailed understanding of these dynamic processes is crucial optimize the overall performance efficiency LNPs....