In Indonesia, there are many types of citrus where parts the fruit, leaves, and peel can be utilized as food, drinks, spices, medicine. This research aims to determine phytochemical characteristics, antioxidant activities, anti-inflammatory activity through inhibition NF-κB sEH, main phytoconstituents three fruits that commonly used herbs in Indonesia. The flesh

Taro (Colocasia esculenta L.) is a plant with long history of use in traditional medicine several countries worldwide. The corm taro and two commercial products were analysed due to total phenolic, flavonoid, luteolin, antioxidant properties. was extracted water for phytochemical screening, flavonoids, screening showed that it contains secondary metabolites tannins, saponins, triterpenoids, quinones. results the determination flavonoid content extract, Product 1, 2 capsule obtained 19.34 ±...

Passion fruit (Passiflora edulis) leaf extract is rich in flavonoids, which possess anti-inflammatory properties. This study aimed to enhance the effect of through a nanoparticle gel formulation. Nanoparticles (NEP) were prepared using ionic gelation with Carbomer 940 base. The efficacy NEP was evaluated vivo carrageenan-induced paw edema model rats. Five groups (n=5) tested: negative control (Carbomer base), positive (Sodium Diclofenac), and three formulations concentrations 1% (NEP-1), 3%...

The development of science has found a way to prevent skin aging in menopausal women. One the therapies is estrogen replacement therapy (17β estradiol). Skin women associated with decreased ERα expression. Leunca fruit (Solanum nigrum L) known contain phytoestrogens and potential as an antiaging agent. purpose this study was predict anti-aging effect Solanum ethanol extract compounds through Erα 1A52 [A] activation pathway. research method active substance analysis metabolite profiling...

Background: Enhalus acoroides (seagrass) possesses valuable bioactive compounds, including quercetin, with potential therapeutic applications, notably antidiabetic effects. However, the poor solubility and low bioavailability of compounds like quercetin limit their clinical efficacy. Phytosomes, phospholipid-based nanocarriers, represent a promising strategy to overcome these limitations. This study aimed develop characterize E. extract-loaded phytosomes enhance its bioavailability. Methods:...

Tomatoes (Solanum lycopersicum Mill.), a common vegetable in Indonesia, contain high levels of lycopene, which is good for the body. This research further investigates activity polar and nonpolar fractions tomatoes as elastase tyrosinase inhibitory, cytotoxic agents. The extraction procedure used maceration, fractionation through liquid-liquid fractionation, purification phytochemical substances achieved application thin layer chromatography. Elastase inhibitory was analyzed using...

Background: Phenol compounds and flavonoids are known have antioxidant activity. Sterculia genus has secondary metabolite rich of phenols flavonoids. Objective: The aim this study the activity antioxidants stipulata Korth. Woods leaves by FRAP method. Materials methods: Extraction done using n-hexane, ethyl acetate, methanol. methanol extract was determined method also total content, flavonoids, phytochemical screening. Results: wood 4.74 ± 1.03 FeEAC (mol/g) while 41.17 1.99 (mol/g). Total...

Introduction: Some Rubus were reported had anti-skin aging activity. fraxinifolius was one of genus which lives in Indonesian highland. Objective: This study to examine elastase, tyrosinase, and oxidant inhibitory activity R. stem (RFS) extract. Methods: Extraction done by a Soxhlet apparatus using methanol as solvent. Elastase inhibition determined, based on the formation p-nitroaniline. Tyrosinase evaluated mushroom tyrosinase sample with L-DOPA substrate. The antioxidant determined DPPH...

Numerous therapeutic compounds have been isolated from naturally abundant organic resources, which may offer economical and sustainable sources of with safe efficacious biological activities. In the cosmetics industry, natural anti-aging activities are eagerly sought. Thus, we prepared various extracts Rubus fraxinifolius leaves used enzyme inhibition assays to isolate protective effects against skin aging. Two triterpenoids were Poir. leaves. The structures characterized by spectroscopic...

: Objective: Rubus fraxinifolius and R. rosifolius are found growing in mountainous areas of West Java potentially act as an antioxidant. The objective this research was to examine the antioxidant activity J. Sm. Poir. leaves. Methods: Dried leaves powder were extracted using Soxhlet apparatus with n-hexane, ethyl acetate, methanol. extracts evaporated, determined DPPH free radical scavenger methods well FRAP reduction capability. Total phenolic contents from extract gave best measured by...

The active metabolites of Colocasia esculenta L. and Zingiber officinale have been reported to reduce pain exert anti-inflammatory effects. This study aimed examine the analgesic effects a combination C. Z. extract. Thirty rats mice were each divided into 6 groups (n=5), namely normal group, negative control, positive control (Nadiclofenac), 3 test given extract (dose 1.3 mg/20 gBW, 2.6 5.2 gBW). Winter's method was used for tests by inducing carrageenan in rat paws, Sigmund's...

Lectins are non-enzymatic proteins that attach to carbohydrates and exhibit diverse biological activities found in Colocasia esculenta rhizomes. This study determined the optimal conditions for purifying isolating lectin from C. rhizome. The methods involved preparation of crude extracts with variations salting in, followed by out, precipitation phosphate buffer saline (PBS), then all were analyzed sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Purification isolation...

Background: In Indonesia, people commonly treat pain and inflammation with herbs. Passiflora edulis leaves extract (PLE) is known to contain many chemical compounds that are useful as analgesic anti-inflammatory treatments. However, there very limited scientific literature reports the results of P. in reducing inflammation. Objective: This research aims evaluate antinociceptive effects PLE. Method: PLE was extracted by Ultrasonic-Assisted Extraction (UAE). The at doses 20, 40 80 mg/200g BW...

Background: The use of drugs, including aminoglycoside drugs and anticancer is one the things that can cause toxicity to kidneys. Therefore, development agents function as nephroprotectors continues be researched. Objective: This study aims obtain a nephrotoxic experimental animal model for testing nephroprotective agents. Method: treatment was normal group, groups given single dose Cisplatin 7 mg/kgBW i.p (Cis), Doxorubicin 25 (Dox-25), repeated 4 twice/week two weeks (Dox-4 dose),...

Ethnobotanically in Indonesia, Diospyros celebica Bakh is recognized as having antidiabetic activity. This study aimed to isolate compounds from the leaves of Eboni (Diospyros celebica). D. were dried and extracted with 96% ethanol, then fractionated purified guided by antioxidant activity test, α-glucosidase inhibitory dipeptidyl peptidase-4 (DPP-4) test until bioactive isolates obtained. The identified their structures determined based on NMR 1H, 13C, 2D, LCMS/MS spectroscopic data....

Doxorubicin chemotherapy is a widely used treatment for various cancers, including breast, ovarian, and uterine among others. However, long-term use can cause nephrotoxicity side effects. Some citrus flavonoids have demonstrated nephroprotective activity; therefore, this study aimed to test the effectiveness of

Passionfruit (Passiflora edulis) leaves are proven to contain flavonoids especially quercetin and showed a significant antinociceptive effect at acetic acid-induced wriggling. Modification of passionfruit leaf extract into nanoparticles can provide therapeutic effects precisely, quickly, optimally. This study aimed the method preparation, characterization nanoherbal (NPL) evaluate its safety profiles analgesic effect. NPL was synthesized using ionic gelation methods, with 3 formula...

Objective: The leaves of Lantana camara L., Eclipta prostrata (L.) L. and Cosmos caudatus Kunth. are rich in flavonoids, saponins essential oils. This study was carried out to determine the antiplatelet effect three plant extracts on ADP-induced platelet aggregation. Methods: samples consisted clopidogrel as positive control, aquadest negative control test with concentrations 40, 60, 80 100 mg/ml. Platelet Rich Plasma (PRP) added for each extract concentration. absorbance measured at 600 nm,...

Abstract Elastase is a proteinase enzyme that can reduce elastin by dividing specific peptide bonds. Therefore, the inhibition of elastase activity in dermis layer be used to maintain skin elasticity. Materials inhibit cosmetic ingredient dealing with aging. Increased desire healthy without chemicals, encourages use materials from natural sources such as plants Indonesia, country has high biodiversity, including Garcinia latissima Miq. Clusiaceae family. The purpose this study was explore...

Pendahuluan: Tanaman Rubus fraxinifolius dapat ditemukan di daerah pegunungan Jawa Barat. Penelitian sebelumnya menunjukkan bahwa tanaman ini memiliki aktivitas antioksidan yang sangat kuat. Kandungan senyawa polifenol pada berkontribusi secara substansial terhadap dan metode ekstraksi akan mempengaruhi kandungan tersari. Pada penelitian dilakukan evaluasi pengaruh organ daun, buah muda batang R. serta antioksidannya. Metode: Bagian buah, diekstraksi cair padat maserasi, refluks soxhlet...

Elastases are protease enzymes, which mainly hydrolyze proteins of the connective tissue, so they have a significant impact on human disease. Rubus rosifolius is one species found in Indonesian mountains, and it has potential as an elastase inhibitor. The objective this research was to examine vitro inhibitor activity R. leaves dock different ligands its constituents against target protein Porcine Pancreatic Elastase (PPE) receptor.Dried powder extracted using Soxhlet apparatus with...

Bahan alam dengan aktivitas imunomodulator, antiinflamasi, dan antioksidan dapat digunakan sebagai terapi suportif infeksi SARS-CoV2. Tujuan penelitian standardisasi mutu keamanan propolis bahan baku obat Covid-19 serta uji antioksidan. Sampel serbuk terdiri dari dua jenis: mikroenkapsulasi mengandung wax (SMPW) non (SMP). Standardisasi meliputi parameter spesifik spesifik. Uji menggunakan metode FRAP ABTS. Kadar total flavonoid SMPW SMP sebesar 0,31% 1,59%. fenolik 83,9082 98,0821 mg GAE/g....