A5001284196- Medicinal Plant Research
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Natural Compound Pharmacology Studies
- Phytochemistry and Biological Activities
- Natural Products and Applications
- Essential Oils and Antimicrobial Activity
- Biological Stains and Phytochemicals
- Traditional and Medicinal Uses of Annonaceae
- Agricultural and Biological Research
- Diverse Scientific Research Studies
- Phytoestrogen effects and research
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Coconut Research and Applications
- melanin and skin pigmentation
- Biological Activity of Diterpenoids and Biflavonoids
- Food and Agricultural Sciences
- Morinda citrifolia extract uses
- Ziziphus Jujuba Studies and Applications
- Tea Polyphenols and Effects
- Plant-Derived Bioactive Compounds
- Coffee research and impacts
University of Indonesia
2016-2025
IPB University
2025
Universitas Muhammadiyah Banjarmasin
2024
National Nuclear Energy Agency of Indonesia
2023
National Research and Innovation Agency
2023
International Islamic University Malaysia
2023
Pelita Harapan University
2023
State University of Jakarta
2022
Universitas Esa Unggul
2021
Mahidol University
2020
Background: Caesalpinia bonduc (L.) Roxb are traditionally used in Indonesia to treat various diseases, but still limited study about different part of this plant. Objective: The aim was screen the phytochemicals, evaluate total flavonoid and phenolic contents as well antioxidant activity ethanol extract root, stem, leaves, seed kernel C. bonduc. Methods: Each plant were extracted by reflux using 70% solvent for 2 h repeated 3 times. Total content determined aluminium chloride colorimetric...
Diabetes mellitus (DM) is recognized as a serious global health problem that characterized by high blood sugar levels. Type 2 DM more common in diabetic populations. In this type of DM, inhibition α-glucosidase useful treatment to delay the absorption glucose after meals. As megabiodiversity country, Indonesia still has lot potential unexploited forests be developed medicine source, including inhibitor. study, we determine inhibitory activity 80% ethanol extracts leaves and twigs some plants...
To evaluate antibacterial activity of the Indonesian water soluble green tea extract, Camellia sinensis, against clinical isolates methicillin–resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR–P. aeruginosa). Antimicrobial extract was determined by disc diffusion method minimum inhibitory concentration (MIC) twofold serial broth dilutions method. The tested bacteria using in this study were standard strains S. P. aeruginosa, obtained from...
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Dengue infections are still a worldwide burden, especially in Indonesia. There is no specific medication against the dengue virus. Recently, many types of research have been conducted to discover new drug for virus using natural resource extracts. Indonesia, as tropical country, has wide biodiversity. several medicinal plants Indonesia that believed possess anti-dengue activity, such Myristica fatua, Cymbopogon citratus, and Acorus calamus plants. We an vitro laboratory experiment extracts...
Curculigo latifolia is a plant in the Hypoxidaceae family commonly used herbal medicine. The study objective was to evaluate antioxidant and anti-elastase properties of C. extracts vitro silico as candidate for antiaging active ingredients. This identified secondary metabolites hexane (HE), ethyl acetate (EAE), ethanol (EE) from root (R), stem (S), leaf (L) organs by LC-ESI-MS evaluated inhibitor elastase activity. An evaluation performed using ABTS, Beta Carotene Bleaching (BCB), Ferric...
One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research predict active compounds as inhibitors from extract. Both multivariate statistical and machine learning approaches were improve confidence predictions. After performance comparisons with other methods, random forest chosen make predictive model for activity samples. Feature...
Diabetes mellitus is a noncontagious disease and leading cause of death globally. It characterized by disorder in glucose metabolism, resulting uncontrolled hyperglycemia. Various classes type 2 DM therapy have demonstrated therapeutic benefits, but the global incidence continues to rise, necessitating discovery new agents for diabetes. This study aims determine most potent Uncaria sclerophylla Roxb leaf fraction as an α-Glucosidase inhibitor, accompanied Absorption, Distribution,...
The p53 signaling pathway plays a critical role in regulating the cell cycle, apoptosis, and senescence, making it key target cancer research. aim of this study was to investigate effects an ethanol extract from stem Ziziphus nummularia on proliferation expression genes involved MCF-7 breast cells. To achieve this, real-time quantitative PCR (RT-qPCR) used evaluate mRNA downstream linked cycle including CycE or CCNE1, RBL1, E2F1. Molecular docking simulations using Molegro Virtual Docker...
Kalanchoe species have been used as herbal medicines in traditional Asian medicine. One of the that has potential a medicinal plant and is still limited its studies ceratophylla . This study investigated effects drying methods, namely, freeze (FD) hot air (HAD), on bioactive compounds, phenolics, flavonoids, antioxidants leaves stems. The content compounds K stems was identified with gas chromatography‐mass spectrometry (GC‐MS) analysis. In addition, antioxidant activity K. also measured....
Hanjeli, a functional food plant still rarely known to the general public, with Latin name Coix lacryma-jobi L variant ma-yuen. Hanjeli has fruit seeds that can be used as nutritious source and have biological activity. This study aimed record nutritional content of hanjeli evaluate antioxidant activity alphaglucosidase inhibitor antidiabetic. were evaluated for their profile by analyzing proximate, mineral, phytoconstituent, total phenolic flavonoid contents seed extract. The extract was...
Background: Rhinachantus nasutus (L.) Kurz (Rnz) is a plant that has the potential to be an antioxidant as well anti-diabetic medication. Traditional medicine used preparations made from roots, stems, and leaves of Rnz treat diabetes. Aim: This study aimed determine leaf extract by inhibiting activity dipeptidyl peptidase IV (DPP IV). Method: samples were extracted using Ultrasound-Assisted Extraction (UAE). Following that, capacity was determined trapping 2,2-diphenyl-1-picrylhydrazyl...
The roots of Spatholobus littoralis Hassk, obtained from Central Kalimantan, were extracted using a combined ultrasound-microwave-assisted extraction method with ethyl acetate as the solvent. results demonstrated potent antioxidant activity, an IC50 value 43.18 µg/mL, which correlates total flavonoid content (26.85 ± 0.059 mgQE/g) and phenolic (145.152 0.04 mgGAE/g). Although vitamin C exhibited higher activity (IC50 2.71 µg/mL), S. still hold significant potential natural source.
Aging is a very complex biological-chemical process and influenced by both internal external factors. Several biochemical pathways that modulate premature aging include increased reactive oxygen/nitrogen species, extracellular matrix degradation, other pathways. This study aims to evaluate the antioxidant capacity, anti-hyaluronidase, human dermal fibroblast cell proliferation of C. latifolia extract determine antiaging activity. Each was evaluated for its capacity various test methods,...
Five new manzamine alkaloids (1–5) and salt forms of two known manzamines (6 7), along with seven compounds (8–14) the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On basis results combined spectroscopic analyses, structure kepulauamine A (1) was determined to possess unprecedented pyrrolizine moiety, while others functional group variants manzamines. These exhibited weak cytotoxicity, moderate antibacterial activity, mild inhibition against...
Saponin is a group of compounds contained in natural materials that have amphiphilic properties and can reduce surface tension. The reduction tension caused by soap compound (Latin = sapo) disrupt hydrogen bonds water. Red frangipani plant (Plumeria rubra) known to saponin content. research objectives were identify the content red extract which could Part (flowers, leaves stems) was extracted using five kinds solvents. Each extracts obtained then tested for qualitatively. Extract from each...
This work covers the effectiveness of White tea extract as a green corrosion inhibitor and is correlated to strength stability bonding between phenolic molecule Fe atoms in mild steel how this interaction can be studied by altering concentration temperature. has received considerable attention due its capability been extensively using electrochemical techniques. However, accurate systematic functional group identification surface modification have missing. Our study sought demonstrate...
Context: Dermal aging is one of the events caused by a decrease in structure skin tissues due to various factors. Molineria latifolia plants empirically used medicine and can be developed treat dermal problems. Aims: To evaluate M. compounds as antiaging, particularly inhibiting upregulation collagenase, gelatinase, hyaluronidase using an silico. Methods: Ligands are 46 from plant obtained previous studies native ligands target proteins were generated via PubChem RSCB protein database. In...
Background: Treatment for type-2 diabetes mellitus focuses on the incretin hormone, Glucagon-Like Peptide-1 (GLP-1). However, it has a short half-life. Inhibition of enzyme Dipeptidyl peptidase IV (DPP IV) required maintaining active form GLP-1. Based previous studies highest activity DPP inhibition white tea extract, this study conducted fraction extract using rat blood serum (ex vivo). Objectives: This aims to evaluate inhibitory from extract. Methods: White leaves extracted with ethanol....
Introduction. Researchers usually use herbal combinations to explore and develop traditional medicine obtain additional benefits in the treatment of diseases, including diabetes. This study aims evaluate hypoglycemic effect combination Andrographis paniculata (Burm. f.) Wall ex Nees Caesalpinia sappan Linn extract (APCSE) on diabetes-induced rats. There has not been sufficient research this combination; however, single studies these plants have widely conducted. Materials Methods. Male...
Andrographis paniculata, Syzygium cumini, and Caesalpinia sappan are used as traditional medicines to treat diabetes mellitus. Therefore, this study aims examine the antidiabetic effects acute toxicity of combined extract (1:1:1) A. S. C. (ASCE). The effect was tested using rats model, induced by a high-fat diet double dose streptozotocin injection 35 mg/kg BW. Subsequently, diabetic in experimental group were treated with 75 BW 150 ASCE, those control metformin 250 After seven days...