Diabetes mellitus (DM) is recognized as a serious global health problem that characterized by high blood sugar levels. Type 2 DM more common in diabetic populations. In this type of DM, inhibition α-glucosidase useful treatment to delay the absorption glucose after meals. As megabiodiversity country, Indonesia still has lot potential unexploited forests be developed medicine source, including inhibitor. study, we determine inhibitory activity 80% ethanol extracts leaves and twigs some plants...

Antioxidant activity and identification of antioxidative compounds Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The was extracted with acetone the extract concentrated using rotary vacuum evaporator. DPPH tiocyanate methods used to examine antioxidant extract. exhibited strong in method IC50 41.21 µg/ml. Chemical analysis indicated that compound alkaloid group. Key words : Antioxidative activity, sp., Sponges, alkaloid.

Objective: This research aimed to determine the phytochemical composition and antioxidant properties in vitro of three types propolis collected from region South Sulawesi Province Indonesia. Methods: Samples propolis: smooth, rough mix were extracted with 96% ethanol. The ethanolic extracts (PEE) was dried studied their by using FRAP (Ferric Reducing Antioxidant Power) DPPH radical scavenging assays. Total phenolic compounds quantified Folin-Ciocalteu, total flavonoid contents also...

Natural deep eutectic solvents (NADES) have been shown to be more effective in extracting plant marker compounds than are organic solvents.In this study, mixtures of choline chloride or betaine with three combinations sugar molecules (glycerol, xylitol, and sorbitol) acids (lactic acid, citric malic acid) were used as ultrasonic-assisted extraction (UAE) trans-cinnamaldehyde coumarin from cinnamon bark [Cinnamomum burmannii (Nees & T. Nees) Blume].Optimization conditions obtain the optimal...

Javanese turmeric (Curcuma xanthorrhiza Roxb.) is known for its diverse pharmacological activities due to rich phytoconstituents, including curcuminoids and xanthorrhizol. Typically, these compounds are extracted using organic solvents, which pose health environmental risks. Therefore, safer more environmentally friendly green extraction methods being developed. This study investigated the effect of ultrasound-assisted (UAE) combined with natural deep eutectic solvents (NADES) based on...

The evaluation of the cause an acute encephalopathy can be challenging due to nonspecific presentations and many potential etiologies. Ranolazine-induced has seldom been reported in literature. We report a case ranolazine-induced with myoclonus. A 78-year-old male past medical history coronary artery disease (CAD) refractory angina on ranolazine, chronic kidney (CKD) stage III, multiple other comorbidities presented hospital after fall complaints generalized weakness. patient, during...

Purpose: To determine the effectiveness of temporary keratoprosthesis in facilitating successful combined penetrating Keratoplasty and vitreoretinal surgery. Study Design: Retrospective interventional case series. Place Duration Surgery: Department Ophthalmology, Peshawar Medical College, from January 2020 December 2023. Methods: A retrospective study was conducted which included 15 patients who underwent keratoprosthesis-assisted Data for pre postoperative visual acuity, IOP, retinal...

Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anemic case is due to iron deficiency.This study investigated efficacy Moringa oleifera L leaves extract as booster supplement help overcome in community.Methods: It was a randomized, double-blind, placebo-controlled women (hemoglobin 8-12g/dL), which water moringa examined add-on therapy subject treated with ferrous sulfate (200mg/ tablet).Thirty-five 16-49 years old were divided into 17 18...

The high demand for cosmetics has had a great impact on the development of innovative products in cosmetic industry. availability raw materials become common problem Materials from nature can act as alternative sources, such Ixora javanica. Several studies have shown potential I. javanica an antioxidant and skin lightening agent. objectives present study were to develop optimize green ultrasound-assisted deep eutectic solvent extraction Eleven solvents evaluated based efficiency parameters;...

During this era of new drug designing, medicinal plants had become a very interesting object further research. Pharmacology screening active compound would be time consuming and costly. Molecular docking is one the in silico method which more efficient compare to vitro or vivo for its capability finding plants. In method, three-dimensional structure becomes important molecular methods, so we need database that provides information on structures chemical compounds from Indonesia. Therefore,...

To optimize the ionic liquid based microwave-assisted extraction (IL-MAE) of polyphenolic content from Peperomia pellucida (L) Kunth. The IL-MAE factors as experimental design parameters, including microwave power, time, concentration, and liquid–solid ratio had been involved. Response surface methodology Box–Behnken were used to obtain predictive model (multivariate quadratic regression equation) optimization process. response was analyzed by using yields total value. Based on obtained...

Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and effects. In this study, we investigated the bioactive compound in vivo properties of smooth rough from Tetragronula sp. To further identify markers propolis, LC-MS/MS was used, results were analyzed by Mass Lynx 4.1. Rough Tetragonula microcapsulated with maltodextrin arabic gum. Propolis...

Background: NADES is an alternative solvent in the extraction of metabolites from plants which has many environmental benefits, such as low toxicity, biodegradability, can dissolve polar and non-polar compounds, costs simple preparation. Objective: This study aims to determine effect natural deep eutectic solvent-based ultrasonic-assisted (NADES-UAE) on enrichment caffeine chlorogenic acid extract green coffee beans (Coffea canephora). Methods: The powders were extracted using NADES-UAE...

Sirtuin 1 (SIRT1) is a class III family of protein histone deacetylases involved in NAD+-dependent deacetylation reactions. It has been suggested that SIRT1 activators may have protective role against type 2 diabetes, the aging process, and inflammation. This study aimed to explore identify medicinal plant compounds from Indonesian Herbal Database (HerbalDB) might potentially become candidate for through combination silico vitro methods. Two pharmacophore models were developed using...

Natural deep eutectic solvent (NADES) is an alternative approach in natural product extraction with various advantages, including low toxicity, biodegradable, and suitable phytochemical compounds a wide range of polarity. Chlorogenic acid (CGA) caffeine, well-known compound the coffee bean, have potential health benefits. This study aims to optimize betaine–sorbitol NADES-based ultrasound-assisted (UAE) method CGA caffeine from Robusta green beans determine inhibitory activity robusta...

Pluchea indica leaves (PIL) is a polyphenolic-rich plant. Polyphenols, such as phenolics and flavonoids, are natural antioxidants. This study aims to evaluate the ability of deep eutectic solvent (NADES) based on ultrasonic-assisted extraction (UAE) for highly efficient polyphenolic antioxidant compounds from PIL. Choline chloride-urea (ChCl-U) was selected screening 17 types NADES. uses Response Surface Methodology (RSM) help determine optimal conditions. The variables include molar ratio,...

The stingless bee, Tetragonula sapiens, is one of the species producing propolis in Indonesia. To date, there still limited information about standard characteristics and biological activity propolis. This study investigated standardized extract Indonesian terms its potency for controlling diabetes high blood pressure vitro, accordance with parameters. Three types extracts; i.e., ethanolic (EEP), spray-dry without wax (SDPNW), (SDPW); were prepared from T. sapiens bees collected South...

Seven antioxidative compounds were isolated from the EtOAc extract of aerial part C. sessiliflora (Japanese name, tanukimame) by activity-guided fractionation with 2,2-diphenyl-1-picrylhydrazyl (DPPH). Among compounds, hydroxyeucomic acid showed strongest free radical-scavenging activity, which was almost identical to that epigallocatechin gallate, against DPPH. Orientin and isoorientin strong anti-peroxidative activities toward linoleic protective effects bactericidal action tert-butyl...