Gut dysbiosis has a role in the pathogenesis of lupus. Synbiotic supplementation may restore balance gut microbiota. This study investigated whether synbiotics could improve microbiota and systemic inflammation lupus patients. randomized, double-blind, placebo-controlled trial was conducted adult erythematosus (SLE) Subjects were randomized to receive either or placebo. Fecal microbiota, hs-CRP, IL-6, IL-17 measured at baseline after 60 days. Patients who fulfilled inclusion criteria into...

Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anemic case is due to iron deficiency.This study investigated efficacy Moringa oleifera L leaves extract as booster supplement help overcome in community.Methods: It was a randomized, double-blind, placebo-controlled women (hemoglobin 8-12g/dL), which water moringa examined add-on therapy subject treated with ferrous sulfate (200mg/ tablet).Thirty-five 16-49 years old were divided into 17 18...

The present study aims to investigate whether the antihyperglycemic effect of Murraya koenigii is mediated by antioxidant properties and insulin mimetic effect.Thirty Spraque-Dawley rats were induced hyperglycemia streptozotocin nicotinamide (STZ-NA). STZ-NA diabetic treated with an ethanolic extract 200 mg/kg b.w 400 b.w. One group was glibenclamide (1 b.w). After administration for four weeks, sacrificed. Blood organ samples collected under a fasting condition. body weight blood glucose...

Context: The molecular mechanism of doxorubicin (DOX) cardiotoxicity involves overproduction free radicals that leads to intracellular calcium dysregulation and apoptosis. Mangiferin (MGR), a naturally occurring glucosylxanthone, has antioxidant cardioprotective properties. However, its cardioprotection yet be revealed.Objective: This study determines whether the effect MGR is caused by on regulation.Materials methods: Male Sprague–Dawley rats were induced DOX intraperitoneally with total...

Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported strong association between the HLA genotype CBZ-induced SJS/TEN. We investigated SJS/TEN in Javanese Sundanese patients Indonesia. Nine unrelated with 236 healthy controls were genotyped for HLA-B their allele frequencies compared. The HLA-B*15:02 was found 66.7% SJS/TEN, but only 29.4% tolerant...

The animal model has been widely used and contributed vastly to the scientific research over years. While it can be as an alternate subject in a study, selection of is crucial assess investigate influence environment genes on pathogenesis disease. Many factors contribute choosing animal. They ranged from similarities with modelled object, easily looked after less expensive cost, good reproductive performance, ability produce blood tissue samples, well-known genetic composition, status...

Current standard management of diabetic foot ulcers (DFUs) consists surgical debridement followed by soak NaCl 0.9% gauzes tight infection and glycaemic control. Nowadays the use advanced platelet-rich fibrin (A-PRF) has emerged as an adjunctive method for treating DFUs. This study was conducted to demonstrate ability combine A-PRF + HA a complementary therapy in DFUs healing related with angiogenesis,inflammation granulation index process.This open label randomized controlled trial Koja...

<b>Aim:</b> The cardiotoxicity effect of doxorubicin (DOX), a widely used antitumor agent has restricted its clinical application. aim the current study was to explore potential protective mangiferin, naturally occurring glucosylxanthone, that have antioxidant activity by iron-complexing ability in mitochondria, against DOX-induced cardiac toxicity rats comparison with other antioxidants namely Sylimarin (SYL) and Vitamin E (VitE). <b>Methods:</b> Mangiferin given orally at dose 50, 100...

Apium graveolens (celery) is an edible and traditionally medicinal plant that used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect pharmacodynamics pharmacokinetics latter drugs. The aim study to assess effects administrating extract on captopril pharmacokinetics. Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given (10 mg/kg Body Weight (BW)) orally, while II pretreated orally (40 BW) hour...

Iron deficiency anemia (IDA) in heart failure (HF) is associated with poor functional capacity. Several studies reported the benefit of iron therapy HF IDA on improving Therefore, we attempt to investigate effect oral supplementation capacity patients IDA.A double blind randomized controlled trial was conducted National Cardiovascular Center Harapan Kita Hospital Universitas Indonesia. A total 54 HFREF were enrolled and either Ferrous Sulphate (FS) 200 mg three times a day or placebo 1:1...

Background and Objectives: Dengue viruses (DENV) is a mosquito-borne members of the Flaviridae family.To date, more than 2.5 billion people in over 100 countries are at risk infection, approximately 20 million infections were reported annually. Currently, There no specific antiviral treatment available for DENV infection. Natural products possess wide range biological biochemical potential. Among them, plants one most important sources discovering new drugs therapy. Our previous study,...

Hypertension is a silent killer that causes kidney, heart, and stroke damage if not handled properly. In Indonesia, the prevalence of population with high blood pressure 34.11% women 36.85% higher than men 31.34%, this shows fairly value so special attention needed on hypertension therapy. It known currently there are 6 types pharmacological therapy for one newest renin inhibitor class (Aliskiren). Indonesia has diverse natural wealth in form flora fauna, more 30,000 medicinal plants 9500...

The percentage of infertility cases in this world is about 50%. Seahorses (Hippocampus spp.) are widely used traditional medicine. Several studies suggest that seahorses have ethnopharmacological characteristics, such as fertility, antioxidants, and antifatigue. purpose study was to determine whether seahorse extract (SE) comes L.) has an effect on fertility serum biochemistry rats induced by depo medroxyprogesterone acetate (DMPA).All animals were with 1.25 mg/kg BW DMPA. Animals grouped...

Occupational pesticide exposure, chlorpyrifos (CPF) in particular, may adversely affect the thyroid. The purpose of this study was to evaluate determinants thyroid function as indicated by serum concentration thyroid-stimulating hormone (TSH) among Indonesian vegetable farmers with primary exposure CPF.A total 151 participated study. sociodemographic and occupational characteristics participants were obtained using a structured interviewer-administered questionnaire. A validated quantitative...

Dengue virus (DENV) is one of the most common viral infections found Indonesia and tropical regions, no specific antiviral for DENV. has several herbal medicine that were not explored their potency as This study was done to evaluate activity toxicity 4 derived fractions: Hexane (CA1), ethyl acetate (CA2), buthanol (CA3 ) water (CA4) Cassia alata leaf extract (CA) an drug The DENV treated with various concentration added Huh-7 it-1. decrease titer determined by Focus assay. measured MTT In...

The accumulation of unpaired α-globin chains in patients with β-thalassemia major may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, is a potent scavenger lipid radicals the membranes red cells (RBCs) major.To evaluate effects α-tocopherol on hemolysis stress markers RBC major.Forty subjects included this randomized controlled trial were allocated to...

One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, prominent catalyst in CPF bioactivation, highly polymorphic. The objective our study was to evaluate role CYP2B6*6, which contains both 516G>T and 785A>G polymorphisms, toxicity, as represented by concentration 3,5,6-trichloro-2-pyridinol (TCPy), among vegetable farmers Central Java, Indonesia, where has been commonly used.A cross-sectional conducted 132 farmers. Individual socio-demographic...

Abstract Background Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used agriculture for controlling pest. There growing concern that pesticide exposure, particularly chlorpyrifos (CPF) combined with other occupational characteristics determine the level of can lead to further health impacts farmers. Our objective was evaluate cumulative exposure among farmers exposed CPF by using validated algorithm. Methods We conducted cross-sectional study 152...

Background: Liver is sensitive against hypoxia and will stabilize HIF-1α. At the same time, produce reactive oxygen species (ROS) which can be scavenged by Cygb. The purpose of our study to know, if normobaric induce Cygb expression its association with HIF-1α stabilization.Methods: This an experimental using 28 male Sprague-Dawley rats, 150-200 g weight. Rats are divided into 7 groups: control group treatment groups that kept in hypoxic chamber (10% O2: 90% N2) for 6 hours, 1, 2, 3, 14...

Indonesia is an archipelagic country with a mega biodiversity, among others, in the marine area. Seahorses (Hippocampus spp.) are fish known to have biocompounds used traditional medicine "Jamu," such as Hippocampus comes L. (HCL). The present study aims analyze and compare chemical contents of cultured seahorse (CS) natural (NS) extracts.The CS NS were identified morphometrically. After freeze-drying, seahorses ground into powder grinder. was extracted ethanol water solvent. extract...

Neuroglobin (Ngb) is highly expressed in the suprachiasmatic nucleus, and can regulate Per1 gene expression. It still not known whether Ngb also influences Cryptochrome (Cry). Cry implicated hypertension primary aldosteronism (PA) mice. There a strong correlation between Obstructive Sleep Apnea (OSA) PA. We propose to prove that play role OSA with PA.Subjects were recruited consecutively from residents of Jakarta, Indonesia; subjects aged 30-65 years moderate severe included study. was...

Cervical cancer is a leading cause of death among women worldwide, particularly in Indonesia. The main treatment advanced-stage cervical radiation; however, the outcomes do not meet required expectations. [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione] has been reported several studies for its potency therapy. This study aims to investigate clinical and molecular [(malondialdehyde (MDA) NF-κB levels] effects, apoptotic index, safety Biocurcumin (BCM-95) as radiosensitiser...