A series of novel asymmetrical mono-carbonyl analogs curcumin (AMACs) were synthesized and evaluated for cytotoxic activity using BSLT MTT assay against Vero, HeLa, MCF7 cell lines. The structures the compounds confirmed by FTIR, 1H-NMR, 13C-NMR, mass spectral data. results cytotoxicity evaluation showed that exhibited moderate to very high toxic in (LC50 value 29.80–1704.23 µM); most compound HeLa lines, which is comparable cisplatin (IC50 40.65–95.55 µM), tested lines 7.86–35.88 µM)....

Introduction: Ageratum conyzoides Linn is one of the Indonesian herbs are used as folk medicine. There many studies to therapeutic activity. However, study influence in extraction parameters and how standardize different batches plant still limited. Objective: The present was designed investigate on variables matter, yield, phytochemical profile, total quercetin from A. L. leaves extract. also evaluates Liquid Chromatography-Mass Spectroscopy (LC-MS) TLC fingerprint profiles extract...

Breast cancer (BC) is a multifactorial disease involving many pathways and target molecules. Multi-target therapy through multi-compound herbal medicines an alternative strategy to treat BC. In the present study, we elucidate molecular mechanism of Ocimum basilicum (OB) as anticancer agent using system bioinformatic approach investigate its cytotoxic effect against MCF-7 cells. We performed network pharmacology (NP) docking studies provide scientific information regarding underlying anti-BC...

Prior study has shown that Ageratum conyzoides L. extract containing quercetin been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha matrix metalloproteinase (MMP-9) expression. Target of osteoarthritis (OA) treatment was in the synovial joint requiring a drug delivery system. The aim this prove efficacy quercetin-loaded lecithin-chitosan nanoparticles on OA model rats observed its effect interleukin (IL-1) β, MMP-9, MMP-13, disintegrin...

Apium graveolens (celery) is an edible and traditionally medicinal plant that used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect pharmacodynamics pharmacokinetics latter drugs. The aim study to assess effects administrating extract on captopril pharmacokinetics. Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given (10 mg/kg Body Weight (BW)) orally, while II pretreated orally (40 BW) hour...

To analyze the effects of Ageratum conyzoides L. on monosodium iodoacetate induced osteoarthritis rats. Thin layer chromatography was performed to constituents babandotan extract leaves. White male Sprague–Dawley rats used in this study were divided into 6 groups: normal control and negative groups, both given 0.5% carboxymethyl cellulose; positive group that glucosamine chondroitin suspension (486 mg/200 g B.W.); 3 dose variation groups including 1, 2, 40, 80, 160 B.W. respectively day 29...

Background: Binahong is a plant that has the potential to be used as traditional herbal medicine in Indonesia, and several kinds of classes compounds, one them flavonoids glycosides (vitexin). Previous research reported binahong leaves have pharmacological activities antihyperglycemic, antihyperlipidemic, antibacterial, others. A proven efficacious needs standardized ensure quality its safety. Objective: This study aimed characteristics simplicia obtained from Bogor, West Java. Materials...

Introduction: Sargassum polycystum is one of marine algal which has a potent antioxidant anticancer activities. This research aims to investigate phytochemical composition, activity and in vitro cytotoxicity on cervical HeLa cancer. Methods: collected from Dompu beach, Lombok, Nusa Tenggara Barat Province, Indonesia, were extracted into organic solvent n-hexane, ethylacetate, chloroform ethanol, respectively. Subsequently, extracts applied for Thin Layer Chromatography (TLC) analysis,...

Indonesia is one of the richest countries with respect to plants resources. People from various ethnic, language, and religious groups have used as alternative medicines, health foods beverages for hundreds years. To establish modern application these understudied plant resources, ethnopharmacological data more than 40 leguminous in Indonesia, spanning western eastern parts Indonesian archipelago, were reviewed. In particular, bioactive secondary metabolites, including flavonoids, described...

Objectives: This study aimed to evaluate the role of a clinical pharmacist intervention in decreasing subsequent and drug-related problems (DRPs) among coronary heart disease (CHD) inpatients with at least one previous DRP. Methods: pre-experimental pre-post design was carried out from January April 2017 DRP general hospital Tangerang District, Banten, Indonesia. Clinical DRPs were documented prospectively by pharmacist, classified using Version 6.2 classification scheme Pharmaceutical Care...

The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance SPMs in repair remains to be fully elucidated heart. In this study, we focused on maresin-1 (MaR1) and examined reparative effects MaR1 cardiomyocytes. treatment increased cell size cultured neonatal rat Since expression fetal...

Oriental Journal of Chemistry is a peer reviewed quarterly research journal pure and applied chemistry. It publishes standard papers in almost all thrust areas current chemistry academic commercial importance. provides platform for rapid publication quality papers, reviews letters. abstracted indexed reputed National International agencies.

Patients with diabetes are 1.6 times more likely to use complementary alternative medicine than nondiabetic patients. Previous studies have shown that Anredera cordifolia (Tenore) Steen. (A. cordifolia) leaf extract has the capacity lower blood glucose, but actual mechanisms unclear. Therefore, in this study, we explored effect of A. on metabolism fatty acids and amino acids. Six-week-old male Wistar rats were randomly divided into six experimental groups (n = 5 per group). Two fed a regular...

Objective: Malaria is an infection disease caused by plasmodium parasite with high prevalence in tropic and subtropic countries. The aim of this work was to design screening gallic acid derivatives as inhibitors malarial dihydrofolate reductase (DHFR) silico docking.Methods: were designed expanding the carboxyl group open-chain moiety L-threonine-allyl esters, well modify hydroxy groups on aromatic ring methoxyl derivatives. In approach has been utilized finding potential antimalaria...

Osteoclasts are multinucleated giant cells with bone resorbing activity. We previously reported that the expression of transcription factor NFAT2 (NFATc1) induced by receptor activator NF-kappaB ligand (RANKL) is essential for formation cells. subsequently identified L-Ser in differentiation medium as necessary NFAT2. Here we searched serine analogs antagonize function and suppress osteoclasts marrow well RAW264 An analog thus identified, H-Ser(tBu)-OMe x HCl, appeared to production...

Background: Eleutherinol is a naphtoquinone derivative that has strong affinity to bind with estrogen alpha receptors (ERα). This compound can be found in Dayak Onion Bulbs (Eleutherine bulbosa Mill.). Objective: The purpose of this study analyze the effects extract on growth bone hypoestrogen model rat. Methods: A total 36 female white rats Sprague-Dawley were divided into 6 groups. All groups receive CMC Na 0,5% (sham group), (negative tamoxifen (positive three level dayak onion bulbs...

A series of novel asymmetrical mono-carbonyl analogs curcumin (AMACs) were synthesized and evaluated for cytotoxic activity using the brine shrimp lethality test (BSLT) methyl thiazolyl tetrazolium assay against Vero, HeLa, MCF7 cell lines. The structures compounds confirmed by Fourier transform infrared spectrophotometry (FTIR), 1H-nuclear magnetic resonance (NMR), 13C-NMR, mass spectral data. results cytotoxicity evaluation showed that exhibited moderate to very high toxic in BSLT,...

Turbinaria deccurrens Bory contains bioactive compound that is beneficial for health. one of many species brown seaweed grows in Indonesian marine life and has been known to have cytotoxic activity. The aim this study determine fucoxantin content the activity extract fraction T. decurrens on colon cancer cell lines. Cytotoxic assay ethanolic extract, n-hexane, ethyl acetate fractions against HCT-116 by MTS using Cell Counting Kit-8 (CCK-8). Fucoxantin were analyzed Reversed-Phase High...

Objective: To analyze the effects of topical gel that consists quercetin nanoparticles on mono iodoacetate-induced osteoarthritis.
 Methods: Injection lecithin-quercetin into chitosan-tocopheryl polyethylene glycol succinate (TPGS) was used to prepared nanoparticle. Evaluation parameter for nanoparticle including polydispersity index, zeta potential, particle size using analyzer and morphology were executed a transmission electron microscope. The evaluation includes organoleptic also...

Introduction: Gallic acid is a naturally polyphenolic which shows cytotoxicity against several cancer cells, as well it displays chemo-preventive activity attributed to its strong apoptosis- inducing and antioxidant effects. Thus, gallic has become an attractive substance be further developed due cytotoxic activity. This study aimed synthesize nanoparticle coating with alginate-chitosan, evaluate breast T47D cells. Methods: was synthesized using ionic gelation method. The yield, size...

In cardiovascular surgery ischemia-reperfusion injury is a challenging problem, which needs medical intervention. We investigated the effects of curcumin on cardiac, myocardial, and mitochondrial parameters in perfused isolated working Guinea pig hearts. After preliminary experiments to establish model, normoxia was set at 30 minutes, hypoxia 60, subsequent reoxygenation minutes. Curcumin applied perfusion buffer 0.25 0.5 μM concentrations. Cardiac measured were afterload, coronary aortic...