Curculigo latifolia is a plant in the Hypoxidaceae family commonly used herbal medicine. The study objective was to evaluate antioxidant and anti-elastase properties of C. extracts vitro silico as candidate for antiaging active ingredients. This identified secondary metabolites hexane (HE), ethyl acetate (EAE), ethanol (EE) from root (R), stem (S), leaf (L) organs by LC-ESI-MS evaluated inhibitor elastase activity. An evaluation performed using ABTS, Beta Carotene Bleaching (BCB), Ferric...

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have a broad range of clinical indications and are recommended by various guidelines for the management diabetes, heart failure, chronic kidney disease. However, prescribing rates these agents suboptimal towards intended in many countries, including Indonesia. The aim this study was to analyze practices SGLT2is among endocrinologists, cardiologists, nephrologists A qualitative method utilized provide comprehensive understanding phenomenon....

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have a broad range of clinical indications and are recommended by various guidelines for the management diabetes, heart failure, chronic kidney disease. However, prescribing rates these agents suboptimal towards intended in many countries, including Indonesia. The aim this study was to analyze practices SGLT2is among endocrinologists, cardiologists, nephrologists A qualitative method utilized provide comprehensive understanding phenomenon....

The roots of Spatholobus littoralis Hassk, obtained from Central Kalimantan, were extracted using a combined ultrasound-microwave-assisted extraction method with ethyl acetate as the solvent. results demonstrated potent antioxidant activity, an IC50 value 43.18 µg/mL, which correlates total flavonoid content (26.85 ± 0.059 mgQE/g) and phenolic (145.152 0.04 mgGAE/g). Although vitamin C exhibited higher activity (IC50 2.71 µg/mL), S. still hold significant potential natural source.

Aging is a very complex biological-chemical process and influenced by both internal external factors. Several biochemical pathways that modulate premature aging include increased reactive oxygen/nitrogen species, extracellular matrix degradation, other pathways. This study aims to evaluate the antioxidant capacity, anti-hyaluronidase, human dermal fibroblast cell proliferation of C. latifolia extract determine antiaging activity. Each was evaluated for its capacity various test methods,...

Background: Bone defect is the loss of some bone tissue which can be caused by several factors, namely trauma, infection, tumor, or congenital abnormalities. Efforts to repair defects done giving grafts. This study used a xenograft derived from bovine bone, hydroxyapatite. Hydroxyapatite combined with Ellagic acid polyphenol has antioxidant and anti-inflammatory properties are expected reduce Interleukin-6. Interleukin-6 marker that indicates presence an inflammatory process. Objective: To...

Introduction. Researchers usually use herbal combinations to explore and develop traditional medicine obtain additional benefits in the treatment of diseases, including diabetes. This study aims evaluate hypoglycemic effect combination Andrographis paniculata (Burm. f.) Wall ex Nees Caesalpinia sappan Linn extract (APCSE) on diabetes-induced rats. There has not been sufficient research this combination; however, single studies these plants have widely conducted. Materials Methods. Male...

Andrographis paniculata, Syzygium cumini, and Caesalpinia sappan are used as traditional medicines to treat diabetes mellitus. Therefore, this study aims examine the antidiabetic effects acute toxicity of combined extract (1:1:1) A. S. C. (ASCE). The effect was tested using rats model, induced by a high-fat diet double dose streptozotocin injection 35 mg/kg BW. Subsequently, diabetic in experimental group were treated with 75 BW 150 ASCE, those control metformin 250 After seven days...

Context: Dermal aging is one of the events caused by a decrease in structure skin tissues due to various factors. Molineria latifolia plants empirically used medicine and can be developed treat dermal problems. Aims: To evaluate M. compounds as antiaging, particularly inhibiting upregulation collagenase, gelatinase, hyaluronidase using an silico. Methods: Ligands are 46 from plant obtained previous studies native ligands target proteins were generated via PubChem RSCB protein database. In...

Nitric oxide (NO) is produced from the conversion of L-arginine by NO synthase (NOS) and regulates a variety processes in gastrointestinal tract. Considering increased activity arginase colitis tissue, it speculated that could inhibit synthesis competing for same substrate, resulting exacerbation colitis. We examined role its relationship to metabolism dextran sulfate sodium (DSS)-induced Experimental was induced mice administration 2.5% DSS drinking water 8 days. Treatment inhibition done...

Curculigo latifolia (family Amaryllidaceae) is used empirically for medicinal purposes. It distributed throughout Asian countries, especially Indonesia. This study aimed at standardizing the C. plant, analyzing its phytochemical profile, and evaluating pharmacological effects. The powder from each organ (root, stem, leaves) was standardized organoleptically microscopically. Samples were extracted by graded maceration using hexane, ethyl acetate, ethanol. extracts determined total phenolic...

Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model asthma, we examined whether administration ameliorated airway hyperresponsiveness inflammation by altering metabolism. Experimental asthma was induced mice via mite crude extract (50 µg/day) on 5 consecutive days (days 0-4, sensitization) day 11 (challenge). Oral (250 mg/kg)...

Aplikasi pemesanan makanan dan minuman berbasis java diharapkan dapat membantu dalam yang sebelumnya masih secara manual menjadi terkomputerisasi. pada rumah makan cepat saji D’besto merupakan suatu sistem memberikan kemudahan melakukan transaksi pemesanan. Sehingga mempermudah segala proses sehingga meminimalisir kesalahan pencatatan data. Tujuan pembuatan aplikasi ini adalah pekerjaan data ketersediaan menu penjualan agar lebih mudah. Metode penelitian digunakan metode grounded (grounded...

Recently, arginase is suggested to regulate nitric oxide production by competing with synthase for the same substrate, L-arginine, in experimental asthma. We investigated role of and its relationship after spinal cord injury. Rats were subjected laminectomy complete transection their cords (injury group) or only (sham group). In injury group, I was increased macrophages at edge, peak observed 48 h However, decreased significantly group despite synthase2 mRNA expression compared sham group....

The associations of serum arginase I with L-arginine, 3-nitrotyrosine, and fractional exhaled nitric oxide (FENO) were evaluated cross-sectionally in healthy Japanese workers. median (minimum-maximum) levels I, FENO people (n = 130) 14.6 (0.94-108.1) ng/mL, 81.0 (0.27-298.6) pmol/mg protein, 14.0 (5.0-110.0) parts per billion, respectively. Significant correlations FENO, percent predicted forced expiratory volume 1 s (FEV1 (% predicted)) observed, immunoglobulin E (IgE), NOx, sex allergy...

Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as source superoxide anion radical (O2－) oxidative associated with asthma has not yet been examined detail. Here we investigated pathophysiological changes XOR an experimental model induced by house dust mite Dermatophagoides farinae (Df). In lungs Df-treated mice, production O2 － from increased and nitrite concentrations decreased, whereas protein expression remained...

Context: Curcuma xanthorrhiza, a native to Indonesia, has been recognized as potential medicinal plant. Xanthorrhizol (XTZ), curcumin (Cur), bisdemethoxycurcumin (BDMC), and demethoxycurcumin (DMC) are the main major metabolites with different bioactivities. Thus, selective extraction of these markers is required. Aims: To characterize use natural deep eutectic solvents (NADES) for XTZ curcuminoids (CURS) from C. xanthorrhiza. Methods: Four NADES, comprising glucose:lactic acid (Glu:LA,...

Curculigo latifolia Dryand.Ex W. T. Alton is a plant reported to have antioxidant and anti-aging activities. Studies shown the interaction of compounds from this with target proteins associated antiaging in silico. This study therefore examines silico activity selected using unreported proteins, including elastase, TNF-alpha, Tyrosinase. Antiaging screening these was carried out AutoDock 14.0 software. A total forty-six (46) were successfully docked each protein. The results showed that test...

The Job comfort in a work is factor having decisive influence onthe increas e of efficiency and effectiveness which the equipment technology aresome supporting facilities improving productivity company. Besides inputting data into computers, user operators i n PT.MI seat material division also mak RF (Receiving Form) , receive goods, put goods make settings warehouse, bringing about negative effects such as accidents occupational diseases. Based on observations questionnaires distributed to...