A5068073682- Acute Myeloid Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Cervical Cancer and HPV Research
- Cancer Risks and Factors
- Workplace Health and Well-being
- Autoimmune Bullous Skin Diseases
- Dementia and Cognitive Impairment Research
- Intestinal and Peritoneal Adhesions
- Chronic Myeloid Leukemia Treatments
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Connective tissue disorders research
- Cancer-related gene regulation
- Renal and related cancers
- Anatomy and Medical Technology
- Plant and animal studies
- Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Smoking Behavior and Cessation
- Cerebrospinal fluid and hydrocephalus
- Hypertrophic osteoarthropathy and related conditions
University of Pennsylvania
2022-2023
Eastern Virginia Medical School
2020-2021
Hospital of the University of Pennsylvania
2021
University of Memphis
2019
Hull and East Yorkshire Hospitals NHS Trust
2015
Acute myeloid leukemia (AML) carries poor survival and high recurrence rate. We conducted a retrospective analysis of AML patients (
Abstract Background Obturator hernia is rare and accounts for less than 1% of all abdominal wall hernias. It represents a diagnostic challenge due to its nonspecific signs symptoms. Case presentation We present case an 89-year-old caucasian female with 12-hour history right medial thigh pain. Computed tomography scan revealed obturator small bowel obstruction. The was successfully repaired laparoscopically without any need resection. She discharged on postoperative day 2 uneventful recovery...
Combining population genetic studies with demographic surveys in long-lived clonal herbs can yield insight into the dynamics of plant populations. In this study, we assayed diversity and spatial structure a understory herb, Trillium recurvatum, that has been focus study spanning 26 years at Meeman Biological Station Memphis, Tennessee, USA. Using set five newly developed simple sequence repeat markers first reported here, assessed 1) extent within site, 2) degree to which varies stage class...
BACKGROUND Platypnea orthodeoxia syndrome (POS) presents with positional dyspnea and hypoxemia defined as arterial desaturation of at least 5% or a drop in PaO2 4 mmHg. Causes POS include variety cardiopulmonary etiologies has been reported patients recovering from severe COVID-19 pneumonia. However, clinical presentation outcomes patient multiple interrelated mechanisms shunting not documented. CASE REPORT An 85-year-old man hospitalized for hypertensive emergency pneumonia was diagnosed...
Abstract Cutis verticis gyrata (CVG) is a neurocutaneous syndrome characterized by the formation of folds in scalp that resembles cerebral cortex. We present two cases CVG and intellectual disability with drug‐resistant epilepsy. Recognizing necessary to provide interdisciplinary support for treatment comorbidities associated this entity.
<h3>Introduction</h3> Clinical trials of pirfenidone and nintedanib have shown similar reduced rates lung function decline in patients with idiopathic pulmonary fibrosis (IPF). In 2013 NICE approved for use IPF forced vital capacity (FVC) between 50% 80% predicted. More recently, has been available on an individual patient supply program (IPSP). <h3>Aims</h3> Reporting early experience two tertiary referral centres, focussing characterising the treated population, assessing indications use,...
Abstract Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE). Our aim was to determine the effect of CD40–CD40L activation experimental seizures. CD40 deficient mice (CD40KO) and control (wild type, WT) received pentenyltetrazole (PTZ) or pilocarpine evaluate status epilepticus (SE) respectively. In mice, anti-CD40L antibody administered intranasally before PTZ. Brain samples from human TLE post-seizure were processed expression using histological molecular...
Cigarette smoking is one of the most common modifiable risk factors for developing bladder cancer, with a population attributable 50%–65% in men and 20%–30% women. Bladder cancer arising patients tobacco exposure on average more aggressive has poorer outcomes.1 Continued use during treatment can lower response rates, increase recurrence, overall specific mortality,1 potentially through alteration tumour cell apoptosis, modification drug delivery metabolism, clearance therapeutic agents.2...
e16524 Background: The standard of care for MIBC is neoadjuvant (NAC) cisplatin-based chemotherapy with either 3-4 cycles dose dense MVAC or 4 gemcitabine/cisplatin (GC) followed by radical cystectomy. However, due to toxicity some patients are unable complete intention treat full course chemotherapy. We aim identify any variation in overall survival (OS) and progression-free (PFS) 3 vs GC the setting miUCB. hypothesize that there will be a statistically significant difference OS PFS three...
BACKGROUND: The historical standard of care for locally advanced renal cell carcinoma (RCC) is nephrectomy + active surveillance. Despite a high recurrence rate ( 40%), adjuvant therapy was previously not included in the care. This review pharmacotherapy reflects conflicting results from multiple trials. OBJECTIVE: objective this to summarize efficacy vs surveillance resected early-stage intermediate high-risk carcinoma. METHODS: We performed systematic literature search using PubMed,...
e16554 Background: Cigarette smoking is the strongest modifiable risk factor for bladder cancer and has been implicated in mechanisms of chemotherapy resistance. Prior studies examining tobacco exposure on response were limited by use retrospective design self-report assessment status, potentially under-estimating association risking bias towards null. Cotinine central metabolite nicotine can be detected saliva up to 4 days after use. In this prospective cohort study, we tested between...
Alzheimer’s disease (AD) is the most common type of dementia and affects millions adults over age 60 years. Accurate diagnosis relies on multiple modalities, including neuropsychological testing, cerebrospinal fluid (CSF) biomarkers, amyloid positron emission tomography (PET) imaging. Discordant results between CSF biomarkers PET can be seen in up to 15% cases lead exclusion from clinical trials along with anxiety confusion for patient family. We present two discordance (CSF+, PET-) that...