A5101550091- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Liver physiology and pathology
- Clinical practice guidelines implementation
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Caveolin-1 and cellular processes
- Liver Disease and Transplantation
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Clostridium difficile and Clostridium perfringens research
- Vasculitis and related conditions
- Microscopic Colitis
- Antibiotic Use and Resistance
- Neuropeptides and Animal Physiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Diseases and Immunity
Medical College of Wisconsin
2025
Heidelberg University
2015-2024
University Hospital Heidelberg
2014-2024
University Medical Centre Mannheim
2014-2024
Medizinische Fakultät Mannheim
2020-2023
Max Delbrück Center
2021-2023
Charité - Universitätsmedizin Berlin
2021-2023
Humboldt-Universität zu Berlin
2022
Freie Universität Berlin
2022
University Medical Center
2021
Inhalt 1. Informationen zu dieser Leitlinie 462 1.1. Herausgeber 1.1.1. Federführende Fachgesellschaft 1.1.2. Kontakt 1.1.3. Verfügbare Dokumente zur 1.2. Besonderer Hinweis 1.3. Autoren 1.4. Ziele des Leitlinienprogramms Onkologie 2. Einführung 463 2.1. Geltungsbereich und Zweck 2.1.1. Zielsetzung Fragestellung 2.1.2. Adressaten 464 2.1.3. Verbreitung u. Implementierung d. Leitlinien 2.1.4. Finanzierung der Darlegung möglicher Interessenskonflikte 2.1.5. Gültigkeitsdauer...
Microsatellite instability (MSI)/mismatch repair deficiency (dMMR) is a key genetic feature which should be tested in every patient with colorectal cancer (CRC) according to medical guidelines. Artificial intelligence (AI) methods can detect MSI/dMMR directly routine pathology slides, but the test performance has not been systematically investigated predefined thresholds.
<h2>ABSTRACT</h2><h3>Background</h3> We evaluated the risk of sampling errors in specimens biopsy size, which may be caused by heterogeneous overexpression Her2/neu gastric cancer (GC). <h3>Patients and methods</h3> The study cohort comprised 454 gastrectomy patients with adenocarcinoma stomach or esophago-gastric junction. Tissue micro-arrays (TMAs) served as ‘biopsy procedure' were generated from formalin-fixed paraffin-embedded tissue: five tissue cylinders collected randomly each tumor,...
Dysregulated Notch signaling has a critical role in the tumorigenesis. Jagged1, ligand, is overexpressed various human cancers. Recent studies revealed involvement of Jagged1 colorectal cancer (CRC) development. These basic provide promising potential for inhibition pathway treatment CRC. Herein, we aimed to investigate consequences targeting using shRNA on CRC both vitro and vivo test their inhibit this key element treatment. We found that downregulation with lentiviral Jagged1-shRNA...
Hypoxia-inducible factor-1 (HIF-1)α expression was studied in the gastric carcinogenesis sequence and as a prognostic factor surgically resected gastro-oesophageal junction tumours. Protein examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia dysplasia (n=12) (n=19) diffuse (n=21) adenocarcinoma. The relationship between HIF-1α prognosis assessed resection specimens from 177 patients...
The role of scatter in a cone-beam computed tomography system using the therapeutic beam medical linear accelerator and commercial electronic portal imaging device (EPID) is investigated. A correction method presented which based on superposition Monte Carlo generated kernels. kernels are adapted to both spectral response EPID dimensions phantom being scanned. part calibration procedure converts measured transmission data acquired for each projection angle into water-equivalent thicknesses....
Due to increasing bacterial resistance rates choosing a correct empiric antibiotic therapy is getting more and complex. Often medical doctors use information tools make the right treatment choice.One hundred sixty six participants (77 89 students) were asked provide diagnosis in simple fictive paper case of upper urinary tract infection (UTI) randomized single-blinded study. Participants one four they allowed study or control: 1. free internet access, 2. pharmaceutical pocket guide, 3. guide...
BackgroundAntineutrophil cytoplasmic autoantibody-associated (ANCA-associated) vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCAs directed against proteinase 3 (PR3) or myeloperoxidase (MPO) bind their cell surface-presented antigen, activate neutrophils, and cause vasculitis. An imbalance between PR3 its major inhibitor α1-antitrypsin (AAT) was proposed to underlie PR3- but not MPO-AAV. We measured AAT in healthy individuals patients with AAV studied protective...
Einleitung: Ein einfaches und leicht zugängliches Softwareprogramm mit Informationen über Diagnostik, Leitlinien, lokale Resistenzdaten Antibiotika könnte für niedergelassene Ärzte (NÄ), Klinikärzte (KÄ) Medizinstudenten (PJ) einen Fortschritt in der Verbesserung täglichen Anwendung von antibiotischen Therapien darstellen.