A5078568022- Thyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- SARS-CoV-2 and COVID-19 Research
- Pituitary Gland Disorders and Treatments
- Birth, Development, and Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Growth Hormone and Insulin-like Growth Factors
- Vaccine Coverage and Hesitancy
- Pancreatic function and diabetes
- Health Promotion and Cardiovascular Prevention
- Mesenchymal stem cell research
- Water Quality and Pollution Assessment
- vaccines and immunoinformatics approaches
- Hip and Femur Fractures
- Radioactivity and Radon Measurements
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Pelvic and Acetabular Injuries
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Groundwater and Isotope Geochemistry
Research Institute for Endocrine Sciences
2021-2025
Shahid Beheshti University of Medical Sciences
2021-2025
Tarbiat Modares University
2021-2025
National Nutrition and Food Technology Research Institute
2024
Australian and New Zealand Intensive Care Society
2023
Tehran University of Medical Sciences
2018-2022
Royan Institute
2021
Background Pediatric migraine prophylaxis is indicated when headaches are frequent and/or disabling. We aimed to conduct a study compare the efficacy of cinnarizine and amitriptyline in pediatric prophylaxis. Methods In randomized, double-blind trial, patients aged 4–17 years with who were eligible for enrolled. The primary outcome was reduction response rate ≥50% p < 0.005 respect headache characteristics. secondary disability assessment. evaluated every four weeks three months: T1: week...
This study aimed to assess the groundwater quality and human health risks of nitrate, nitrite, fluoride contamination in rural areas Khaf County, Iran. For this aim, 28 samples were collected from open dug wells during August 2018. Twelve parameters (pH, EC, TDS TH, Cl-, SO42-, HCO3−, NO3−, F−, Ca2+, Mg2+, Na+) have been used evaluate water index. Also, point estimation using HQ formula sensitivity analysis Monte Carlo Simulation (MCS) method, by 10,000 repetitions Oracle Crystal Ball®,...
Abstract Background Type-1 diabetes (T1D) occurs following autoimmune-induced pancreatic beta cells death. Among several treatment modalities, mesenchymal stem (MSCs) transplantation is promising for autoimmune disorders due to immunomodulation, regeneration, and migration damaged tissue upon systemic injection. This study assessed the safety efficacy of intravenous injection autologous bone marrow-derived MSCs in newly diagnosed T1D patients. Methods After receiving informed consent, 21...
This data article aimed to investigate the quality of drinking water Qorveh and Dehgolan Counties in Kurdistan province based on index (WQI) agricultural RSC, PI, KR, MH, Na, SAR SSP indices. Also, Piper diagram was used determine hydro chemical features groundwater area. The calculation WQI for samples indicated that 36% could be considered as excellent 64% were classified good category. results calculated indices indicate all collected are a classification showed dominant type faces region...
Abstract This study investigates the risk of chronic kidney disease (CKD) across four metabolic phenotypes: Metabolically Healthy-No Obesity (MH-NO), Unhealthy-No obesity (MU-NO), Healthy-Obesity (MH-O), and Unhealthy-Obesity (MU-O). Data from Tehran Lipid Glucose Study, collected 1999 to 2020, were used categorize participants based on a BMI ≥ 30 kg/m 2 health status, defined by presence three or following components: high blood pressure, elevated triglycerides, low high-density...
Cell-based therapy has shown promising outcomes in the treatment of cerebral palsy (CP). However, there is no consensus on a standard therapeutic protocol regarding source cells, optimal cell dose, timing and frequency injections, route administration, or use combination therapy. This lack necessitates comprehensive investigation to clarify these crucial yet undefined factors cell-based for CP patients. In this commentary, we discuss compare trends Gross Motor Function Measure-66 following...
Background: Combination therapy with levothyroxine (L-T4) and slow-release T3 (SRT3) in the treatment of hypothyroidism results a normal triiodothyronine/thyroxine (T3/T4) ratio above that L-T4 monotherapy. No clinical study has been reported on SRT3 monotherapy for hypothyroidism. Methods: This was conducted two parts. In first part, 20 patients primary serum thyrotropin (TSH) >30 mU/L were randomized into three groups receiving 1.6 μg/kg L-T4, equivalent doses or L-T3 0.55 4 weeks....
Evidence regarding the relationship between thyroid hormone levels within normal range and incidence of chronic kidney disease (CKD) in adults is scarce. This study aimed to identify association thyrotropin (TSH) free thyroxine (FT4) with CKD a large cohort over long-term follow-up. prospective study, an 18-year follow-up, included 4118 without from Tehran Study (TTS). Participants were categorized by tertiles TSH (low-normal, middle-normal, high-normal) abnormal TSH. The outcome was...
Metabolic syndrome (MetS), defined as the coexistence of interrelated cardiometabolic risk factors, is limited by ignoring severity disease and individuals with a pre-metabolic state. We aimed to develop first age- sex-specific continuous MetS score in adult population using confirmatory factor analysis (CFA) based on components Middle East. Using data from population-based Tehran Lipid Glucose Study (TLGS) I II datasets, we conducted CFA single 8933 adults (20-60 years old) totally, age sex...
The available evidence indicates that the severity of metabolic syndrome tends to worsen progressively over time. We assessed trajectory age and sex-specific continuous MetS score (cMetS-S) its association with development diabetes during an 18-year follow-up.In a prospective population-based Tehran Lipid Glucose Study, 3931 eligible participants free diabetes, aged 20-60 years, were followed at three-year intervals. examined trajectories cMetS-S nine years using latent growth mixture...
Abstract Background The immunity induced by primary vaccination is effective against COVID-19; however, booster vaccines are needed to maintain vaccine-induced and improve protection emerging variants. Heterologous boosting believed result in more robust immune responses. This study investigated the safety immunogenicity of Razi Cov Pars vaccine (RCP) as a heterologous dose people primed with Beijing Bio-Institute Biological Products Coronavirus Vaccine (BBIBP-CorV). Methods We conducted...
The evidence suggest that insulin resistance (IR) complicates chronic kidney disease (CKD); however, the longitudinal association of IR with development CKD is unknown.This work aimed to investigate between dynamic course and CKD.In longitudinal, population-based Tehran Lipid Glucose Study, 3071 eligible participants aged 20 years or older were followed for 18 at 3-year intervals. Homeostatic model assessment (HOMA-IR) clinical surrogate markers IR, including triglyceride-glucose index...
Traditional metabolic syndrome (MetS) criteria have several limitations, which hinder its use in clinical practice. To overcome the we investigated association between age- and sex-specific continuous MetS severity score (cMetS-S) cardiovascular disease (CVD) mortality beyond components framework of Tehran Lipid Glucose Study. Participants aged 20-60 years at baseline were included study. We excluded participants with CVD, cancer, corticosteroids, estimated glomerular filtration rate < 30...
This is the first clinical trial to investigate effectiveness of maggot debridement therapy (MDT) for full-thickness burn injuries in comparison conventional silver dressings.Thirty-one cases with (grade III based on ICD-10 classifications version 2019) burns were assigned into larval (15 cases) and treatment (16 groups. Participants MDT group have received loose larvae days 0, 2, 4, 6, while controls a regimen comprised sharp debridement, sulfadiazine, antibiotic therapy, offloading every...
BackgroundWe conducted a phase III, non-inferiority trial comparing safety and efficacy of RCP recombinant spike protein Covid-19 vaccine to BBIBP (Sinopharm).MethodsAdult Iranian population received or in randomized, double blind an additional non-randomized open labeled arms. Eligible participants signed written informed consent two intramuscular injections three weeks apart. In the randomized arm, intranasal dose adjuvant-only preparation were given recipients at day 51 respectively....
Objectives The current study aimed to examine how the trajectory of a body shape index (ABSI) could predict mortality in prospective cohort 5587 participants. Methods A Growth Mixture Model (GMM) was employed identify ABSI and trajectories spanning from 2000 2018. Multivariate Cox regression models with hazard ratio (HR) 95% confidence intervals (CIs) were built assess association death all-cause cardiovascular disease (CVD) trajectories. Results We found that individuals low ABSI–marked...
Abstract Objectives This study aimed to estimate the incidence rate of re-fracture and all-cause mortality in patients with hip fractures caused by minor trauma first year following event. Materials methods is a retrospective cohort over 50 years age conducted referral hospital located Tehran (Shafa-Yahyaian). Using information system (HIS), all hospitalized due during 2013–2019 were included study. We investigated occurrence death one after primary fracture. Results A total 945 307,595...
Aim We aimed to investigate the effect of BMI variability on CVD and mortality explore mediation effects main cardiovascular risk factors contributing this association. Method Participants aged 40-65 years were pooled from three cohort studies(ARIC [Atherosclerosis Risk in Communities], MESA [Multi-ethnic Study Atherosclerosis], TLGS [Tehran Lipid Glucose Study]. employed root mean squared error fractional mixed model calculate measurement period. In event assessment period, hazard ratios...
Chronic kidney disease (CKD) can progress over time and cause renal replacement therapy. Studies showed the association between metabolic syndrome (MetS) CKD. Current evidence is from cross-sectional studies. There a need for robust data big prospective cohort studies with long-term follow-up. This study investigated CKD MetS after 18 years of follow-up.Among 15,255 participants aged ≥20 at baseline (1999-2005), exclusion CKD, cancer, use corticosteroids, 8987 entered followed three-year...