A5070553195- Mesenchymal stem cell research
- melanin and skin pigmentation
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Skin Protection and Aging
- Virus-based gene therapy research
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Vitamin K Research Studies
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Tissue Engineering and Regenerative Medicine
San Diego State University
2016-2018
Sharp Memorial Hospital
2017
Ferris State University
2012
The relative actions and synergism between distinct myocardial-derived stem cell populations remain obscure. Ongoing debates on optimal population(s) for treatment of heart failure prompted implementation a protocol isolation multiple from single myocardial tissue sample to develop new insights achieving regeneration.Establish robust cardiac culture consistently generate 3 human biopsy.Isolation endogenous was performed samples routinely discarded during implantation left ventricular assist...
Biological significance of c-Kit as a cardiac stem cell marker and role(s) c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because varied discrepant findings. Alternative experimental models are required contextualize reconcile discordant published observations biology provide meaningful insights regarding clinical relevance signaling for translational therapy.The main objectives this study follows: demonstrating through combined studies both human...
Recent studies suggest that extrafollicular dermal melanocyte stem cells (MSCs) persist after birth in the superficial nerve sheath of peripheral nerves and give rise to migratory precursors when replacements for epidermal melanocytes are needed on basal layer skin. If a damaged MSC or precursor can be shown primary origin melanoma, targeted identification eradication it by antibody-based therapies will best method treat melanoma very effective way prevent its recurrence. Transcription...
Regenerative therapeutic approaches for myocardial diseases often involve delivery of stem cells expanded ex vivo. Prior studies indicate that cell culture conditions affect functional and phenotypic characteristics, but relationship(s) cultured derived from freshly isolated populations the heterogeneity population remain poorly defined. Functional characteristics vivo will determine outcomes interventional treatment disease, necessitating characterization impact expansion has upon...
What is the cellular origin of melanoma? role do melanocyte stem cells (MSC) and other precursors play in development Are MSCs latent more susceptible to solar radiation? These many questions can be very effectively addressed using zebrafish model. Zebrafish have a robust regenerative capability, permitting study how are regulated recruited at specific times places generate pigment pattern following fin amputation or ablation. They used determine effects environmental radiation on...
Abstract Regenerative therapeutic approaches for myocardial diseases often involve adoptive transfer of stem cells expanded ex vivo . Prior studies indicate that cell culture conditions affect functional and phenotypic characteristics, but relationship(s) cultured derived from freshly isolated populations the heterogeneity population remain poorly defined. Functional characteristics adoptively donated will determine outcomes interventional treatment disease, necessitating characterization...