A5018535005- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Synthesis and Characterization of Pyrroles
- Click Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Chemical Synthesis and Reactions
- Advanced Synthetic Organic Chemistry
- Multicomponent Synthesis of Heterocycles
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- Cyclopropane Reaction Mechanisms
- Synthesis of Indole Derivatives
- Fluorine in Organic Chemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactivity of Heterocycles
- Asymmetric Synthesis and Catalysis
Guangdong Medical College
2024
Indian Institute of Chemical Technology
2016-2023
Academy of Scientific and Innovative Research
2016-2020
Tatar American Regional Institute
2018
University of Hyderabad
2016-2017
A transition-metal-free method for the construction of functionalized quinolines from readily available acetophenones and anthranils is reported. This one-pot reaction cascade involves in situ generation α,β-unsaturated ketones acetophenone via one-carbon homologation by DMSO followed aza-Michael addition subsequent annulation. acted this not only as solvent but also one carbon source, thus providing a highly atom-economical environmentally benign approach synthesis 3-substituted quinolines.
An efficient method to access functionalized quinolines from the readily available saturated ketones and anthranils has been explored. This one-pot cascade reaction involves in situ generation of α,β-unsaturated by copper catalysed dehydrogenation followed aza-Michael addition subsequent annulation.
An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines alkynes in presence K2S2O8 DMSO has been developed. A variety having a diverse range substitution patterns can undergo one-pot cascade process successfully. Effectively, this method uses as one carbon source, thus providing highly atom-economical environmentally benign 4-arylquinolines.
Cu<sup>0</sup>/Fe<sub>3</sub>O<sub>4</sub> catalyzed stereoselective synthesis of <italic>E</italic>-vinyl sulfones from tosylmethyl isocyanide and alkynes. TosMIC act as sulfonyl source.
An efficient one‐pot tandem nano Cu 0 /Fe 3 O 4 ‐catalysed synthesis of sulfur‐containing triazoles from alkynes and azide has been developed. In this newly developed method, the readily available TMS‐azide dimethyl sulfoxide act as nitrogen sulfur sources, respectively. The catalyst was magnetically recovered reused six times without any significant loss activity.
An efficient, one pot tandem, Cu<sup>0</sup>/Fe<sub>3</sub>O<sub>4</sub>catalyzed highly regioselective synthesis of 2,3,4-trisubstituted pyrroles from unactivated terminal alkynes and isocyanides.
The amide bond is prominent in natural and synthetic organic molecules endowed with activity various fields. Among a wide array of methods, substitution on pre-existing (O)C-N moiety an underexplored strategy for the synthesis amides. In this work, we disclose new protocol defluorinative arylation aliphatic aromatic trifluoroacetamides yielding mechanochemically induced reaction either arylboronic acids, trimethoxyphenylsilanes, diaryliodonium salts, or dimethyl(phenyl)sulfonium salts...
An efficient and transition-metal-free strategy for the synthesis of 3-keto-isoquinolines in one pot has been developed from easily accessible 2-(formylphenyl)acrylates phenacyl azides. Various substituted aldehydes azides were successfully employed this transformation to furnish a variety very good yields. A number controlled experiments conducted postulate reaction mechanism. Secondary functionalizations 2-keto-isoquinolins also performed showcase synthetic utility.
Herein, we report the accomplishment of Rh2(II)-catalyzed intramolecular amination aryl azide-tethered 1,3-dicarbonyls to access privileged heterocyclic scaffolds with exclusive diastereoselectivity under simple reaction conditions. This method also allows an unconventional direct α-amination at electron-deficient C(sp3)-H bonds 1,3-diketones afford fused 2-azatricyclo[4.4.0.02,8]decanones and 2,2-disubstituted indolines, which are present in several biologically active alkaloids. Kinetic...
Herein we report a Pd-catalyzed regio- and diastereoselective hydro(hetero)arylation of inactivated alkylidenecyclobutanes. This protocol provides rapid atom-economical route to access 3-cyclobutyl (hetero)arenes with good functionalities toleration. With the assistance directing group, nucleophilic attack happened on bulkier γ-position form quaternary carbon center. Furthermore, selected products exhibited antitumor bioactivities.
We report herein our observation of an unprecedented stereoselective synthesis 2 H -isoindolin-1,3-ylidenes from 2-formylphenyl acrylates and phenacylazide in the presence piperidine.