A5086213315- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Microbial infections and disease research
- Cervical Cancer and HPV Research
- Mass Spectrometry Techniques and Applications
- Medical Imaging Techniques and Applications
- Pharmaceutical studies and practices
- Infectious Diseases and Mycology
Russian Scientific Center of Radiology and Surgical Technologies
2023-2024
University of Lübeck
2024
Cyclotron (Netherlands)
2023
Ministry of Health of the Russian Federation
2023
St Petersburg University
2023
State Research Institute of Highly Pure Biopreparations
2017
The aim of this study was to create and evaluate a cell model designed for in vitro vivo testing anti-human PD-L1 therapeutic diagnostic agents' specificity. Genetically modified cells expressing human (strain CT26-PD-L1) were obtained by retroviral transduction murine CT26 carcinoma cells. gene activity assessed real-time PCR, expression on identified flow cytometry. Cells tested using recombinant single-domain anti-PD-L1 antibodies (nanoantibodies) conjugated with radioisotopes 68Ga or...
Quantification of the immunoreactive fraction (IRF) radioactive isotope-labeled antibodies or their fragments is necessary to assess specific activity radiopharmaceuticals. Traditionally, cells expressing target molecules on surface are used determine IRF, but such analysis time-consuming and has difficulties with standardization.The aim study was develop a fast reliable method for quantitative determination IRF by 68 Ga-labeled VHH PD-L1 based use magnetic particles coated antigen...
The cervical cancer is one of the most common diseases in world. This malignancy seventh highest prevalence oncological disease worldwide and second women Meanwhile need to be infected by human papilloma virus (HPV) absolutely necessary for it further evolution, HPV DNA was found 99.97% cases disease. Except cancer, cause 85% rectal 50% vulva, vagina penis cancers, 20% oropharyngeal 10% larynx esophagus cancers. In 2009, 14 000 were diagnosed with Russia. growth morbidity 19% (in comparison...