A5086842752- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Cancer therapeutics and mechanisms
- Diabetes and associated disorders
- Radiopharmaceutical Chemistry and Applications
- Microtubule and mitosis dynamics
- Mesenchymal stem cell research
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Pharmaceutical studies and practices
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Bacteriophages and microbial interactions
- Diet, Metabolism, and Disease
- Cancer Treatment and Pharmacology
- Medical Imaging Techniques and Applications
- Macrophage Migration Inhibitory Factor
- Mathematical Biology Tumor Growth
- Carcinogens and Genotoxicity Assessment
- Cell Adhesion Molecules Research
Russian Scientific Center of Radiology and Surgical Technologies
2014-2025
Ministry of Health of the Russian Federation
2014-2024
ABSTRACT The MICA and MICB molecules, expressed on the cell membrane in response to cellular stress or cancer transformation, pose significant challenges for immunoassays. They exhibit high sequence structural similarity, alongside considerable allelic polymorphism, with 291 53 known protein sequences, respectively. Some researchers treat as a unified target because of their functional similarities, while others distinguish between them. However, which approach is superior under what...
The aim of this study was to create and evaluate a cell model designed for in vitro vivo testing anti-human PD-L1 therapeutic diagnostic agents' specificity. Genetically modified cells expressing human (strain CT26-PD-L1) were obtained by retroviral transduction murine CT26 carcinoma cells. gene activity assessed real-time PCR, expression on identified flow cytometry. Cells tested using recombinant single-domain anti-PD-L1 antibodies (nanoantibodies) conjugated with radioisotopes 68Ga or...
The review considers the properties of polyploid giant tumor cells a new target for development cancer therapy. Various number are detected in almost all human solid tumors. Their increases under influence hypoxia, radiation, and after chemotherapy. Previously, these were not considered to be worth studying as they do proliferate eventually die result one cell death mechanisms action. Recent data have demonstrated that can give rise daughter possess tumorigenicity characterized stem cells....
Membrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads inhibition proliferation, reduction cytokine production, cytotoxic response, apoptosis lymphocytes. The cells many tumors, regardless their histogenesis, express molecules, thus limiting development an anti-tumor immune response. Glioblastomas are highly malignant recurrent tumors central nervous system. main sources glioblastoma recurrence...
During last years monoclonal antibodies (MAB) directed against vascular endothelium markers demonstrated their efficiency for visualization and targeted delivery of therapeutic drugs to tumors. Endoglin (CD105) which serves as a key element that determines endothelial cells quiescence or activation is one such markers. highly expressed on the growing A first panel MAB endoglin in our country was produced at hybridoma technology laboratory RRC RST named after A.M. Granov. On basis these ELISA...
One of the modern methods treating patients with primary and recurrent brain tumors is radiosurgical irradiation using Gamma Knife, which allows therapeutic doses to be delivered not exceeding 2.5 cm in diameter 1–2 sessions. Tumor cells on periphery this tissue volume that receive lower radiation can resume proliferation serve as a source recurrence. The increase dose may cause necroses formation worsening prognosis. properties glioblastoma survive long after stereotactic are still poorly...
Islet $-cell antibodies (ICA) were studied by immune fluorescence test in the blood serum of total 192 individuals. Blood was sampled after previously nocturnal starving 22 cancer patients with evident type 2 diabetes mellitus (DM2) (in those mainly breast (BC) and corpus uteri (CUC)), 124 without (55 BC 69 CUC), 41 healthy The study revealed ICA 13.6% hormone-dependent tumors DM2, 8.3% CUC impaired glucose tolerance, 6.6% normal absent individuals (a comparison group). detection signs DM2...
Methodological aspects of immunofluorescent detection autoantibodies to Langerhans' islet /З-cell antigens (ICA), a marker indicating early preclinical insulin-dependent diabetes mellitus (IDDM), have been modified and standardized. The distribution levels ICA were evaluated in patients with first diagnosed IDDM their relatives (risk group) (total 298). In newly IDDM, detected 83.3% cases. 15.4% clinically healthy siblings IDDMpatients 8.3% children one whose parents was diabetic...