A5032594742- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Quinazolinone synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Microbial Natural Products and Biosynthesis
- Crystallography and molecular interactions
- Photochromic and Fluorescence Chemistry
- Synthesis of β-Lactam Compounds
- Antifungal resistance and susceptibility
- Synthesis and Reactions of Organic Compounds
- Phytochemistry and Bioactivity Studies
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
- Bacterial Genetics and Biotechnology
University of Oslo
2022-2025
SRM Institute of Science and Technology
2024
Oslo University Hospital
2024
Birla Institute of Technology and Science, Pilani
2017-2023
Birla Institute of Technology and Science - Hyderabad Campus
2017-2022
Institute of Contemporary Art
2022
Hacettepe University
2022
Indian Institute of Science Education and Research Kolkata
2014-2021
University of Hyderabad
2018-2020
Nizam's Institute of Medical Sciences
2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed broad range biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities to tap into its potential, we herein present the synthesis evaluation new usnic acid enaminone-conjugated 1,2,3-triazoles 10–44 antimycobacterial agents. was condensed with propargyl amine give enaminone 8 terminal ethynyl moiety. It further...
In a search for safer and potent antitubercular agents, here library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All compounds were evaluated their activity against Mycobacterium tuberculosis H37Rv (MTB). Among the screened compounds, 5d, 5e, 5h, 5l showed good activity. The 5d have shown very effective (MTB) with MIC 12.5 μg/mL. thoroughly characterized by 1H NMR, 13C HRMS spectral data. We...
Azobenzene-3,3'-dicarboxylic acid exists in photoisomerizable (E) and (Z)-forms. Deprotonation of the carboxylic groups from (E)-form occurs simultaneously, whereas (Z)-form it a stepwise fashion. The mono anionic form (Z)-isomer acts as glycosidase mimic that proceeds through general acid-general base catalytic mechanism. This is first example photoresponsive mimic.
Abstract Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole–coumarin chalcones pyrazole–quinoline were synthesized using multiple‐step reactions. All the compounds well characterized different spectroscopic techniques including 1 H 13 C nuclear magnetic resonance, high‐resolution mass spectroscopy, electrospray ionization–mass spectrometry. The evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv...
An efficient and eco compatible approach for the regio- stereoselective synthesis of structurally diverse novel hybrid heterocycles comprising spiropyrrolidine, indenoquinoxaline indole structural units in excellent yields, has been achieved through a one-pot multicomponent process involving 1,3-dipolar cycloaddition as key step. The component is azomethine ylide generated situ from l-tryptophan reacts with various substituted β-nitrostyrenes affording spiroheterocyclic hybrids. ring system...
A series of isatin oxime ether-tethered aryl 1 H -1,2,3-triazole hybrids were synthesized and screened for their in vitro antitubercular activity against the M. tuberculosis H37Rv strain.
A facile and convenient approach has been designed for the synthesis of novel prototypes that possess advantage two pharmacophores chromene 1,2,3-triazole in a single molecular backbone, were evaluated against Mycobacterium tuberculosis H37Rv strain. The new analogues 1,2,3-triazole-fused spirochromenes accomplished four step synthetic strategy utilizing click chemistry ([3 + 2] Huisgen cycloaddition) ultimate step. synthesized compounds established based on spectral data X-ray crystal...
A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [Et3NH][OAc] as a medium by implementation ultrasound irradiation via click chemistry, affording excellent yields. The present synthetic exhibited numerous advantages such mild reaction conditions, product yields, minimal chemical waste, operational simplicity, shorter time, wide range substrate scope. synthesized compounds were further evaluated in vitro antifungal...
Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target drug-resistant tuberculosis. Here, we disclosing 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library was synthesized using various acids. The compounds were evaluated antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j identified lead with MIC 0.6 μg/ml This compound nontoxic to CHO-K1 cells...
The discovery of new antimicrobial agents as a means treating drug-resistant microbial pathogens is utmost significance to overcome their immense risk human well-being. current investigation involves the development, synthesis, and assessment efficacy novel quinoline derivatives incorporating thiosemicarbazide functionality. To design target compounds (QST1-QST14), we applied molecular hybridization approach link various thiosemicarbazides core with sulfonyl group. Upon synthesis completion...
Abstract A green and efficient protocol has been developed for the synthesis of novel 1,2,3‐triazole‐chromene conjugates ( 7 a‐j ) via ultrasound assisted NaHCO 3 catalyzed first time. Structures all new were deduced by various spectroscopic techniques. The newly synthesized triazole‐chromene evaluated their in vitro antitubercular activity against Mycobacterium tuberculosis (MTB) H37Rv strain. f h found to be most active with MIC value 12.5 μg/mL. Furthermore, screened antioxidant are...