A5062859329- Bacterial Infections and Vaccines
- Bacterial Genetics and Biotechnology
- Legionella and Acanthamoeba research
- Gut microbiota and health
- Escherichia coli research studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Glycosylation and Glycoproteins Research
- Antimicrobial Resistance in Staphylococcus
- Aquatic Invertebrate Ecology and Behavior
- S100 Proteins and Annexins
- Tissue Engineering and Regenerative Medicine
- Protein Structure and Dynamics
- Vagus Nerve Stimulation Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Diseases and Immunity
- Microscopic Colitis
- Synthesis of Organic Compounds
- Infectious Encephalopathies and Encephalitis
- Fish Ecology and Management Studies
- Vibrio bacteria research studies
- Cerebrospinal fluid and hydrocephalus
- Biomedical Ethics and Regulation
- Clinical Nutrition and Gastroenterology
- Heat shock proteins research
University of Virginia
2015-2021
Oregon Health & Science University
2019-2020
University of Maryland, Baltimore
2012
One of the first lines defense present at mucosal epithelial tissues is mucus, which a highly viscous material formed by mucin glycoproteins. Mucins serve various functions, but importantly they aid in clearance pathogens and debris from barriers as innate immune factors. In this study, we describe requirement host monosaccharides, likely derived mucins, for ability Pseudomonas aeruginosa to colonize intestine ultimately cause death Caenorhabditis elegans . We also demonstrate that...
Little is known about how predators or their cues affect the acquisition and allocation of energy throughout ontogeny prey organisms. To address this question, we have been comparing ontogenetic body-mass scaling various traits related to intake use between populations a keystone amphipod crustacean inhabiting freshwater springs, with versus without fish predators. In progress report, analyze new previously reported data develop synthetic picture presence/absence affects food assimilation,...
Bordetella pertussis, the causative agent of whooping cough, secretes and releases adenylate cyclase toxin (ACT), which is a protein bacterial that targets host cells disarms immune defenses. ACT binds filamentous haemagglutinin (FHA), surface-displayed adhesin, until now, consequences this interaction were unknown. A B. bronchiseptica mutant lacking produced more biofilm than parental strain; leading Irie et al. to propose ACT-FHA could be responsible for inhibition. Here we characterize...
Bordetella pertussis is a human pathogen that can infect the respiratory tract and cause disease known as whooping cough. B. uses toxin (PT) adenylate cyclase (ACT) to kill modulate host cells allow survive persist. encodes many uncharacterized transcription factors, very little about their functions. RpoE sigma factor which, in other bacteria, responds oxidative, heat, environmental stresses. RseA negative regulator of sequesters regulate gene expression based on conditions. In pertussis,...
This report provides evidence for motility and expression of flagella by B. pertussis , a bacterium that has been reported as nonmotile since it was first isolated studied. As with bronchiseptica cells can express assemble flagellum-like structure on their surface, which in other organisms implicated several important processes occur vivo . The discovery is motile raises many questions, including those regarding the mechanisms regulation flagellar gene protein and, importantly, role during...
Abstract The mucosal barrier, found lining epithelial cells, serves multiple functions in a range of animals. major structural components mucus are mucins, which heavily glycosylated proteins that either membrane bound or secreted by the cells. Mucins key innate immune system, as they involved clearance pathogens from airways and intestines, their expression is typically upregulated upon cell exposure to variety pathogens. In this study, we identified mucin MUL-1 an factor appears be...
Abstract Autologous fecal transplant (AFT, transfer of ileostomy feces to the colon) for diversion colitis (DC) has not yet been described in children or adolescents. We performed serial AFTs a 16-year-old with Crohn’s disease and DC. As evidenced by endoscopic, histologic, laboratory, multiomic profiling colon, first AFT led interval improvement DC, whereas second reactivated colitis. These findings ultimately guided shared decision-making towards total colectomy.