A5006854962- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Uterine Myomas and Treatments
- Selenium in Biological Systems
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Cancer Treatment and Pharmacology
- Bioactive Compounds and Antitumor Agents
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- Renal cell carcinoma treatment
- DNA and Nucleic Acid Chemistry
- Immune Cell Function and Interaction
- Synthesis and biological activity
- Sarcoma Diagnosis and Treatment
Northwestern University
2016-2021
Rutgers Cancer Institute of New Jersey
2004-2018
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2018
Midwestern University
2017-2018
Rutgers, The State University of New Jersey
2013-2018
Indo-American Center
2018
University of Miami
2015-2017
Sylvester Comprehensive Cancer Center
2015
Cancer Institute of Florida
2004-2005
Memorial Medical Center
2002
Histone H2AX is a ubiquitous member of the H2A histone family that differs from other histones by presence an evolutionarily conserved C-terminal motif, -KKATQASQEY. The serine residue in this motif becomes rapidly phosphorylated cells and animals when DNA double-stranded breaks are introduced into their chromatin various physical chemical means. In present communication we show form H2AX, referred to as γ-H2AX, appears during apoptosis concurrently with initial appearance high molecular...
Derivatives of camptothecins, topoisomerase I inhibitors and 7-hydroxystaurosporine (UCN-01), a protein kinase C (PKC) inhibitor cell cycle checkpoint abrogator, are promising anticancer drugs. We characterized the apoptotic response to camptothecin UCN-01 for 8 human breast carcinoma lines (MCF-7, MCF-7/ADR, T47D, HS578T, BT549, MDA-N, MDA MB231, MDA435) from National Cancer Institute (NCI) Anticancer Drug Screen. MCF-7 T47D cells exhibited marked resistance apoptosis, whereas MCF-7/ADR...
We have used a human leukemia cell line that, after homologous recombination knockout of the gp91-phox subunit phagocyte respiratory-burst oxidase cytochrome b-558, mimics chronic granulomatous disease (X-CGD) to study role oxygen radicals in apoptosis. Camptothecin (CPT), topoisomerase I inhibitor, induced significantly more apoptosis PLB-985 cells than X-CGD cells. Sensitivity CPT was enhanced neutrophilic differentiation, but lost monocytic differentiation. No difference between two lines...
2, 5-bis(5-Hydroxymethyl-2-thienyl)furan (NSC 652287), is a representative of series thiophene derivatives that exhibit potent and selective antitumor activity against several tumor cell lines in the National Cancer Institute Anticancer Drug Screen. NSC 652287 has noticeable for renal produces cures certain corresponding xenografts. The cellular mechanisms action were therefore investigated this study greater detail. most sensitive carcinoma line, A498, exhibited cycle arrest...
To determine overall survival (OS) and factors associated with OS after pelvic exenteration for cervical cancer.Women cancer who underwent (n = 517) were identified from the 1998 to 2011 National Cancer Database. Kaplan-Meier multivariate Cox proportional-hazards analyses performed test associations of potential explanatory variables OS. Analyzed confounders included age, insurance status, income, distance home treatment center, stage, type, surgical margin adjuvant radiation and/or...
Randomized controlled trials have consistently shown that the use of postoperative radiotherapy (RT) for stage I endometrial cancer leads to a reduction in incidence pelvic recurrences without corresponding overall mortality. It was hypothesized mortality associated with receipt RT could be identified large data set greater statistical power.Women surgically staged IA or IB adenocarcinoma who were treated total hysterectomy between 2003 and 2011 National Cancer Data Base. Chi-square tests...
Previous studies in rapidly proliferating rodent cells have suggested that the lethal effect of DNA topoisomerase I inhibitor, camptothecin (CPT) is dependent upon active participation replication (Holm et al. Cancer Res. 49:6365-6368; 1989). The purpose current study was to determine if this relationship applies more slowly growing human cells. In our present study, we employed colon carcinoma cell line, HT-29 (45 hr doubling time). Flow cytometric determination S-phase either by fit model...
Purpose We describe survival disparities among women with uterine, ovarian, or cervical cancer by cancer-specific mean annual hospital volume. Methods National Cancer Database 1998-2011 uterine (n = 441,863), ovarian 223,017), and 146,698) data sets were used. Cancer-specific volumes calculated. Overall (OS) was plotted volume using restricted OS times from Cox regression. Results Uterine, cancers reported 1,651, 1,633, 1,600 hospitals, respectively. Median values of hospitals 8.6...
An alkylating camptothecin (CPT) derivative, 7-chloromethyl-10,11-methylenedioxy-camptothecin (7-CM-MDO-CPT) was recently shown to produce irreversible topoisomerase I (top1) cleavage complexes by binding the +1 base of scissile strand a top1 site. We demonstrate that 7-CM-EDO-CPT (7-chloromethyl-10,11-ethylenedioxy-camptothecin) also induces top1-DNA complexes. 7-CM-MDO-CPT, 7-CM-EDO-CPT, and nonalkylating derivative 7-ethyl-10,11-methylenedioxy-camptothecin (7-E-MDO-CPT) induced reversible...
Abstract Background: Mutated p53 tumor suppressor protein is involved in >50% of all malignancies; however, only recently have candidate drugs designed to target mutations entered clinical trials. COTI-2, an orally bioavailable "third-generation" thiosemicarbazone, was shown restore the structure and function mutant proteins induced growth inhibition a number cell lines. Thus, three-part phase I dose escalation trial COTI-2 initiated with Part 1 reported herein. Methods: A...
Overexpression of bcl-2 is a mechanism drug resistance in cervical cancer. Agents that down-regulate may decrease tumor cell threshold and sensitize cells to chemotherapy. The objective this multi-institutional phase 2 trial was evaluate the efficacy toxicity paclitaxel modulators (13-cis retinoic acid interferon alfa-2b) patients with advanced-stage or recurrent