A5024590396- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Health and Medical Research Impacts
- Health Policy Implementation Science
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Lipoproteins and Cardiovascular Health
- Global Public Health Policies and Epidemiology
- scientometrics and bibliometrics research
- Antioxidant Activity and Oxidative Stress
- Biomedical Ethics and Regulation
- Calpain Protease Function and Regulation
- Health Sciences Research and Education
NIHR Evaluation Trials and Studies Coordinating Centre
2013-2018
University of Southampton
2007-2018
National Institute for Health Research
2013-2018
There is increasing evidence that modified phospholipid products of low density lipoprotein (LDL) oxidation mediate inflammatory processes within vulnerable atherosclerotic lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) present in plaque regions where it acts on to generate the pro-inflammatory lysophsopholipids and oxidized non-esterified fatty acids. This association together with identification circulating Lp-PLA2 levels as an independent predictor cardiovascular disease...
The objective of this study was to assess whether National Institute Health Research (NIHR) Technology Assessment (HTA)-funded randomised controlled trials (RCTs) published in the HTA journal were described sufficient detail replicate practice.RCTs journal.98 RCTs up March 2011. Completeness intervention description assessed independently by two researchers using a checklist, which included assessments participants, intensity, schedule, materials and settings. Disagreements scoring discussed...
HTA Programme funding is governed by the need for evidence and scientific quality, reflecting of National Institute Health Research (NIHR) NHS. The criterion incorporates covering spectrum diseases, but also taking account research supported other funders. This study compared NIHR portfolio with UK burden disease as measured Disability-adjusted Life Years (DALYs). A retrospective cross-sectional using a cohort all funded primary syntheses projects received from April 2011 to March 2016 (n =...
Methods A checklist for assessing intervention descriptions was applied to NIHR HTA funded RCTs published in Health Technology Assessment. The piloted twice on a sample of 10 reports. Kappa scores were generated assess agreement the application. modified and all 98 single trial journal from January 1999 March 2011. Three assessors independently checklist. Disagreements scoring discussed team; differences then explored resolved.
A 2003 survey suggested the number of noncommercial trials in UK was declining. Formation NIHR 2006 and increased research spending by Department Health may have but no data are available.Available on (were obtained from two relevant registries: ISRCTN register for UK, US ClinicalTrials.gov. Data each trial were sorted start year, compared with the: survey, UKCRN portfolio database 2007.The registered rose 25 1990 to 188 1999, peaked at 533 2003, fell back 334 2009. Total similar slightly...
INTRODUCTION: This study compared the National Institute for Health Research (NIHR) Technology Assessment (HTA) Programme portfolio of research with united Kingdom (UK) burden disease, as measured by Disability-Adjusted Life Years (DALYs). METHODS: Design: Cross-sectional study. Setting: The HTA cohort included all funded applications (n = 363) received during period 1 April 2011 to 31 March 2016. sample contained primary and evidence syntheses, purely methodological studies were excluded...