A5060493962- Health and Medical Research Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Acne and Rosacea Treatments and Effects
- Meta-analysis and systematic reviews
- Healthcare cost, quality, practices
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Marine and coastal ecosystems
- Aquatic Ecosystems and Phytoplankton Dynamics
- Pharmaceutical industry and healthcare
- Health Sciences Research and Education
- Tissue Engineering and Regenerative Medicine
- CNS Lymphoma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- HER2/EGFR in Cancer Research
- Ethics in Clinical Research
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- Global Public Health Policies and Epidemiology
- Skin Protection and Aging
- Lymphoma Diagnosis and Treatment
- Marine Biology and Ecology Research
- Vitamin C and Antioxidants Research
University of Southampton
2003-2021
Southampton General Hospital
2021
University Hospital Southampton NHS Foundation Trust
2020
NIHR Evaluation Trials and Studies Coordinating Centre
2013-2018
Wessex Institute of Technology
2018
National Institute for Health Research
2013-2018
Faculty (United Kingdom)
2012
Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human embryonic stem cells (hESCs). The current study aims investigate the effect of environmental O2 tension on carbohydrate utilisation hESCs. Highly pluripotent hESCs cultured at 5% consumed significantly more glucose, less pyruvate and produced lactate compared those maintained 20% O2. Moreover, atmospheric levels expressed OCT4, SOX2 NANOG than To determine whether this difference was a...
Cross-presentation is the presentation by MHC class I of antigenic peptides from exogenous proteins that have been internalized and processed professional antigen-presenting cells, e.g. dendritic cells. We investigated influence particle size antigen load on cross-presentation following delivery microspheres (MS). small particles (0·8-μm) sensitive to proteasome inhibition blockade endoplasmic reticulum-resident complex export, whereas larger (aggregated clumps 0·8-μm MS) resistant these...
HTA Programme funding is governed by the need for evidence and scientific quality, reflecting of National Institute Health Research (NIHR) NHS. The criterion incorporates covering spectrum diseases, but also taking account research supported other funders. This study compared NIHR portfolio with UK burden disease as measured Disability-adjusted Life Years (DALYs). A retrospective cross-sectional using a cohort all funded primary syntheses projects received from April 2011 to March 2016 (n =...
Introduction Acne is one of the most common inflammatory skin diseases worldwide and can have significant psychosocial impact cause permanent scarring. Spironolactone, a potassium-sparing diuretic, has antiandrogenic properties, potentially reducing sebum production hyperkeratinisation in acne-prone follicles. Dermatologists prescribed spironolactone for acne women over 30 years, but robust clinical study data are lacking. This seeks to evaluate whether clinically effective cost-effective...
To assess the time to publication of primary research and evidence syntheses funded by National Institute for Health Research (NIHR) Technology Assessment (HTA) Programme published as a monograph in journal article wider biomedical literature.Retrospective cohort study.Primary synthesis projects HTA were included if they registered NIHR programmes database was planned submit draft final report on or before 9 December 2011.The median at 30 months an external determined searching website.Of...
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral have been identified. We investigated ability of an activating receptor ligand derived from mumps virus, haemagglutinin-neuraminidase (HN) to enhance against tumor cells. HN-expressing B16.OVA induced stronger compared with and also promoted dendritic (DC) toward DC1 phenotype, vitro....
Innovations resulting from research have both national and global impact, so selecting the most promising studies to fund is crucial. Peer review of funding applications part selection process, requires considerable resources. This study aimed elicit stakeholder opinions about which factors contribute influence effective peer UK National Institute for Health Research (NIHR), identify possible minor improvements current processes any major changes or potential innovations achieve a more...
<ns4:p><ns4:bold>Background:</ns4:bold> Over 13,000 new cases of non-Hodgkin’s lymphoma (NHL) are diagnosed in the UK, with approximately 4,900 attributable deaths each year. Diffuse Large B-cell Lymphoma (DLBCL) is most common NHL comprising one third adult cases. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) accepted as international standard first-line regimen, but improvement first line treatment needed. Dysregulated receptor (BCR) signalling has been...
<ns7:p><ns7:bold>Background: </ns7:bold>Anthracycline- and taxane-based regimens form the mainstay of chemotherapy treatment in metastatic breast cancer. In patients who develop resistance to these agents, management options are limited there is no standard care. Thus, investigation into other chemotherapeutic agents warranted.</ns7:p><ns7:p> <ns7:bold>Methods: </ns7:bold>In this non-randomised prospective trial, with human epidermal growth factor 2 (HER-2)-negative locally advanced or...
Objective Previous work has shown that 98% of NIHR Health Technology Assessment (HTA) Programme projects publish in (the peer reviewed journal for the HTA Programme). 68% clinical trials funded by US NIH publish, with 46% publishing within 30 months trial completion. This study aimed to assess time-to-publication primary research (trials, diagnostic studies, surveys and modelling projects) compare this other funding bodies.
INTRODUCTION: It takes on average 17 years to translate a promising laboratory development into better patient treatments or services. About 10 of this innovation process lies within the National Institute for Health Research (NIHR) research pathway. Innovations developed through have both national and global impact, so selecting most studies fund is crucial. Peer review applications part NIHR funding process, but requires considerable resources. The committed improving efficiency...
INTRODUCTION: This study compared the National Institute for Health Research (NIHR) Technology Assessment (HTA) Programme portfolio of research with united Kingdom (UK) burden disease, as measured by Disability-Adjusted Life Years (DALYs). METHODS: Design: Cross-sectional study. Setting: The HTA cohort included all funded applications (n = 363) received during period 1 April 2011 to 31 March 2016. sample contained primary and evidence syntheses, purely methodological studies were excluded...
Introduction: The National Institute for Health Research (NIHR) is a major funder of health research in the United Kingdom. Selecting most promising studies to fund crucial, and external expert peer review used inform funding boards. Our aim was evaluate influence different kinds numbers reviewer scores on Board decisions, how we might modify process reduce workload stakeholders. Methods: mixed method study included i) retrospective cross sectional analysis board second stage applications...