A5089085514- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Cancer Diagnosis and Treatment
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Thyroid and Parathyroid Surgery
- Management of metastatic bone disease
- Cardiac Fibrosis and Remodeling
- Polyomavirus and related diseases
- PI3K/AKT/mTOR signaling in cancer
- Hospital Admissions and Outcomes
- Cell Adhesion Molecules Research
- Botulinum Toxin and Related Neurological Disorders
- Single-cell and spatial transcriptomics
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
Victor Chang Cardiac Research Institute
2024-2025
UNSW Sydney
2024-2025
Monash University
2025
Monash Medical Centre
2024
Royal Adelaide Hospital
2012-2020
Stanford Medicine
2019
Southampton General Hospital
2017
National Hospital for Neurology and Neurosurgery
1981-2013
University College London
1981-2013
SA Health
2012-2013
Single-cell technology has allowed researchers to probe tissue complexity and dynamics at unprecedented depth in health disease. However, the generation of high-dimensionality single-cell atlases virtual three-dimensional tissues requires integrated reference maps that harmonize disparate experimental designs, analytical pipelines, taxonomies. Here, we present a comprehensive transcriptome integration map cardiac fibrosis, which underpins pathophysiology most cardiovascular diseases. Our...
Adjuvant chemotherapy for early breast cancer has improved outcomes but causes toxicity. The UK TACT2 trial used a 2×2 factorial design to test two hypotheses: whether use of accelerated epirubicin would improve time tumour recurrence (TTR); and oral capecitabine instead cyclophosphamide be non-inferior in terms patients' toxicity, quality life, or both.
Abstract Purpose: The main objectives of this phase I and pharmacokinetic, open-label study were to determine the optimally tolerated regimen (OTR), safety, pharmacokinetics, clinical activity lapatinib in combination with letrozole patients advanced solid malignancies. Experimental Design: Patients breast cancer immunohistochemically detectable estrogen or progesterone receptors other cancers eligible. Doses escalated cohorts three subjects from 1,250 a maximum 1,500 mg/d based on...
5-Ethynyl-2'-deoxyuridine (EdU) has transformed DNA replication and cell cycle analyses through fast efficient click chemistry detection. However, commercial EdU kits are expensive, contain proprietary reagents, suboptimal for antibody multiplexing, challenging to use with larger biological specimens, highlighting the need innovation. Here, we report Open-source Multiplexing Methodology Understanding dynamics (OpenEMMU), an optimized, affordable, user-friendly resource using off-the-shelf...
Abstract Activation of CD8 + T cells enable them to control virus infections and tumors. This process involves the differentiation naïve into effector memory states, driven by specific transcription factors (TFs). Previously, we have shown that Granzyme A (Gzma) induction in activated depends on Gata3 establishment a permissive chromatin landscape at Gzma locus. Interestingly, expression is independent IL‐4 signaling, which typically upregulates CD4 cells, suggesting an alternative pathway...
Abstract In the CT26 BALB/c murine model of colorectal carcinoma, depletion regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity both and other BALB/c-derived tumors diverse histological origin. this paper, we show that cross-protection can be conferred by adoptively transferred CD8+ CTLs. Other schedules for inducing have been described, but they do not lead cross-protection. We Treg ablation facilitates development new CTL specificities are normally cryptic,...
3001 Background: Lapatinib is a selective and highly potent dual, competitive inhibitor of ErbB1 ErbB2 tyrosine kinases leading to cell growth arrest and/or apoptosis in dependent tumor lines xenografts. Co-expression ER associated with reduced response rate hormone therapy breast cancer. A rational approach treatment may be block simultaneously both pathways. Methods: Patients (pts) advanced cancer, or PR +, other tumors (e.g., ovarian, endometrial) that would likely respond the combination...
Abstract Intercellular adhesion molecule‐3 (ICAM‐3, CD50), a member of the immunoglobulin gene superfamily, is major ligand for lymphocyte functionassociated antigen 1 (LFA‐1, CD18/CD11a) in resting immune system and plays role as signaling costimulatory molecule on T lymphocytes. In this study we have generated large panel anti‐ICAM‐3 monoclonal antibodies (mAb) show that biological effects these are critically dependent epitope recognized. By using an assay employing COS cells expressing...
Abstract Introduction Bone metastases in patients with breast cancer have serious effects on health including pain, poor mobility, skeletal fractures, spinal cord compression and the need for radiotherapy/surgery. The introduction of intravenous (IV) bisphosphonates, such as zoledronic acid (Z) has significantly delayed onset skeletal-related events (SRE). However, prolonged IV bisphosphonates place burdens upon patient hospital, can also cause renal acute phase toxicities. Ibandronic (I), a...
TPS1144 Background: Bevacizumab is a new humanised monoclonal antibody which targets vascular endothelial growth factor (VEGF) and thereby the neoangiogenic process in cancer. has shown promising anti-tumour effect when given concurrently with taxane-based chemotherapy breast However two neoadjuvant cancer trials have produced conflicting results. The NSABP-B40 study showed significant benefit for bevacizumab only ER+ve patients (pathological complete response (pCR) population 15.2% vs...
<title>Abstract</title> <bold>Background:</bold> Operative vaginal birth (OVB) relies on effective teamwork to optimise outcomes. This study aims explore providers’ perspectives of factors influencing safety and team functionality at OVB. <bold>Methods:</bold> mixed methods involved four maternity sites Monash Health, Australia. Surveys sent healthcare providers invited quantitative qualitative appraisal Semi-structured interviews further explored themes emerging from survey responses....
1015 Background: Neo-tAnGo was an NCRI UK neoadjuvant breast cancer study testing the addition of gemcitabine to anthracycline and taxane-based treatment also sequencing chemotherapy. In a translational substudy, sequential fresh tissue analysed for PAM 50 subgroups. Methods: recruited 831 patients. 162 patients were consented Science, 3 additional samples be taken at diagnosis (diag), mid-chemotherapy (CT) end-CT. Standard methodology used subtyping. Results: Fresh diag received from 123...
<ns7:p><ns7:bold>Background: </ns7:bold>Anthracycline- and taxane-based regimens form the mainstay of chemotherapy treatment in metastatic breast cancer. In patients who develop resistance to these agents, management options are limited there is no standard care. Thus, investigation into other chemotherapeutic agents warranted.</ns7:p><ns7:p> <ns7:bold>Methods: </ns7:bold>In this non-randomised prospective trial, with human epidermal growth factor 2 (HER-2)-negative locally advanced or...