A5049965056- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Photoacoustic and Ultrasonic Imaging
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
Monash University
2020-2025
Australian Regenerative Medicine Institute
2020-2023
Discovery Institute
2023
Pomona College
2023
St Vincent's Hospital
2023
The University of Melbourne
2023
Monash Health
2023
Abstract Activation of CD8 + T cells enable them to control virus infections and tumors. This process involves the differentiation naïve into effector memory states, driven by specific transcription factors (TFs). Previously, we have shown that Granzyme A (Gzma) induction in activated depends on Gata3 establishment a permissive chromatin landscape at Gzma locus. Interestingly, expression is independent IL‐4 signaling, which typically upregulates CD4 cells, suggesting an alternative pathway...
Abstract Science communication is often confined to spoken, written or graphical form, neglecting the integration of other tools that would open inclusive scientific dialog low‐vision community. To address this barrier, members from Monash Rheumatology clinical and laboratory research groups formed a Lupus Sensory team create breakout room at 2023 Exhibit on Autoimmunity. Our goal was develop multimodal displays artworks engage participants with blindness low vision immunological...
The differentiation of naive CD8+ T lymphocytes into cytotoxic effector and memory CTL results in large-scale changes transcriptional phenotypic profiles. Little is known about how genome organization underpin these programs. We use Hi-C to map the spatial long-range contacts within naive, effector, virus-specific cells. observe that architecture cell distinct from configurations, with extensive discrete functional chromatin domains associated effector/memory differentiation. Deletion BACH2,...
SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for treatment but detrimental metabolic effects. Type 1 interferons (IFN) central to pathogenesis may confer GC insensitivity. Glucocorticoid-induced leucine zipper (GILZ) mediates many effects relevant pathogenesis, the effect IFN regulation GILZ unknown. We performed
Aims: Aberrant immune cell activation characterises SLE, in which glucocorticoids (GCs) remain a cornerstone of treatment.However, the unacceptable side effects GCs have created pressing need for similarly broad-acting, but safer, anti-inflammatory agent.The glucocorticoidinduced leucine zipper, GILZ, mediates is independent GC-associated metabolic adverse effects.Previously, we showed that GILZ suppressed permitting inappropriate activation.Therefore, restoring promising therapeutic...
The differentiation of naïve CD8+ cytotoxic T lymphocytes (CTLs) into effector and memory states results in large scale changes transcriptional phenotypic profiles. Little is known about how large-scale genome organisation reflect or underpin these programs. We utilised Hi-C to map the spatial long-range contacts within naïve, virus-specific cells. observed that architecture naive cell was distinct from configurations with extensive discrete functional chromatin domains. However, deletion...
Abstract Virtual memory T (T VM) cells are a unique subset of CD8 +T that have both classical and innate-like immune function. Unlike other cell subsets, VMcells highly dependent on cytokines for their homeostasis selectively depleted in mice lacking IL-15. In aged humans, acquire receptor-associated defects, which may contribute to the decline overall function seen with aging. make up large proportion naive pool individuals, making them an ideal target age-specific therapeutic...
Abstract NaïveCD8 +T cell activation results in a program of proliferation and differentiation that large scale changes phenotype function is critical for pathogen control establishment immunological memory. While these are underpinned by structural biochemical genome regulatory elements, the mechanisms mediate not fully elucidated. Polycomb Repressive complexes (PRC) chromatin remodeling implicated silencing genes encoding crucial developmental regulators. We demonstrated upregulation PRC1...