A5026288560- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- CCD and CMOS Imaging Sensors
- Advanced Image Processing Techniques
- Effects of Radiation Exposure
- Spine and Intervertebral Disc Pathology
- Handwritten Text Recognition Techniques
- Tribology and Lubrication Engineering
- Vehicle License Plate Recognition
- Medical Imaging and Analysis
- Image Processing Techniques and Applications
- Image and Signal Denoising Methods
- Thin-Film Transistor Technologies
- Pain Management and Opioid Use
- Image Processing and 3D Reconstruction
- Advances in Oncology and Radiotherapy
- Advanced Vision and Imaging
Aichi Cancer Center
2019-2025
University of Yamanashi
2023
Doshisha University
2003-2021
Ritsumeikan University
2008-2010
Tokyo Institute of Technology
2003
NEC (Japan)
1983-1985
Abstract This study aimed to evaluate the recent trends in single-fraction conventional radiotherapy (CRT) as palliative treatment Japan, using data from National Database published by Ministry of Health, Labor, and Welfare. Data fiscal year (FY) 2014 FY2022, specifically related utilization CRT, were analyzed. Multi-fraction stereotactic body (SBRT), intensity-modulated (IMRT), brachytherapy excluded. The primary outcome was cumulative annual number CRT courses. Additionally, quarterly...
The impact of three-dimensional (3D) dose delivery accuracy C-arm linacs on the planning target volume (PTV) margin was evaluated for non-coplanar intracranial stereotactic radiosurgery (SRS). A multi-institutional 3D starshot test using beams from seven directions conducted at 22 clinics Varian and Elekta with X-ray CT-based polymer gel dosimeters. Variability in observed, distance between imaging isocenter each beam exceeding 1 mm one institution nine institutions Elekta. calculated PTV...
Abstract Purpose In linear accelerators, deviations in the x‐ray focal spot position significantly affect accuracy of radiation therapy. However, as bore‐type linac systems such Radixact system, cannot be assessed using conventional methods, a new evaluation method is required. This study aimed to develop novel measure and evaluate any from ideal position. Methods A structurally simplified measurement system was developed system. consisted vertically aligned metal bar an ionization chamber,...
Deep inspiration breath-hold (DIBH) is widely used to reduce the cardiac dose in left-sided breast cancer radiotherapy. This study aimed develop a deep learning chest X-ray model for prediction select patients with potentially high risk of irradiation and need DIBH We 103 pairs anteroposterior lateral data (training cohort: n = 59, validation 19, test 25). All underwent breast-conserving surgery followed by radiotherapy: treatment plan consisted three-dimensional, two opposing tangential...
This retrospective study aimed to assess the efficacy and safety of palliative radiotherapy for painful non-bone lesions in patients with advanced cancer. We enrolled who underwent conventional between September 2018 2022. The treatment targets included primary tumor lesions, lymph node metastases, hematogenous other lesions. endpoint was overall pain response rate evaluable patients, determined based on International Consensus Pain Response Endpoint criteria. secondary endpoints survival,...
Abstract Purpose We aimed to evaluate the efficacy and safety of re-irradiation stereotactic body radiation therapy (SBRT) in patients with metastatic epidural spinal cord compression (MESCC) following high-dose conventional radiotherapy. Materials methods Twenty-one met eligibility criteria: an irradiation history 50 Gy 2 equivalent dose 2-Gy fractions (EQD2) or more, diagnosed MESCC cervical thoracic spines, treated SBRT 24 between April 2018 March 2023. Prior treatment was radiotherapy...
Abstract This study aimed to explore the distribution of external radiation therapy (RT) facilities, status related device installations and adoption high-precision RT using Survey Medical Institutions from Ministry Health, Labour Welfare in Japan. Analysis, categorized by hospital size prefecture, provides specific insights into trends treatment facility healthcare capabilities. Data on number devices planning systems (TPS) beds prefecture 1996 2020 were analyzed. In addition, examined...
Gold nanoparticles (AuNPs) can be used with megavolt (MV) X-rays to exert radiosensitization effects, as demonstrated in cell survival assays and mouse experiments. However, the detailed mechanisms are not clear; besides physical dose enhancement, several chemical biological processes have been proposed. Reducing AuNP concentration while achieving sufficient enhancement is necessary for clinical application of AuNPs. Here, we positively charged (+) AuNPs determine effects combined MV on DNA...
Abstract Purpose This study evaluated the trends in platform for stereotactic radiotherapy to brain (SRT), utilizing open data of National Database published by Ministry Health, Labour, and Welfare. Materials methods analyzed from FY2014 FY2021. The practices included were gamma knife surgery (GKS) SRT with a linear accelerator (LINAC). total number outpatient inpatient cases each system was annually. Results From April 2014 March 2022, 212,016 (102,691 GKS 109,325 LINAC) registered...
Gold nanoparticles (AuNPs) are candidate radiosensitizers for medium-energy photon treatment, such as γ-ray radiation in high-dose-rate (HDR) brachytherapy. However, high AuNP concentrations required sufficient dose enhancement clinical applications. Here, we investigated the effect of positively (+) charged radiosensitization plasmid DNA damage induced by 192Ir γ-rays, and compared it with that negatively (-) AuNPs.We observed breaks reactive oxygen species (ROS) generation presence AuNPs...
Polyamines are involved in various biological functions, including cell proliferation, differentiation, gene regulation, etc. Recently, it was found that polyamines exhibit biphasic effects on expression: promotion and inhibition at low high concentrations, respectively. Here, we compared the of three naturally occurring tetravalent polyamines, spermine (SPM), thermospermine (TSPM), N4-aminopropylspermidine (BSPD). Based single DNA observation with fluorescence microscopy together...
Purpose We developed a thermoset shape memory bolus (shape bolus) made from poly‐ε‐caprolactone (PCL) polymer. This study aimed to investigate whether the can be applied radiotherapy as that conformally adheres body surface, created in short time, and reused. Methods The was by cross‐linking tetrabranch PCL with reactive acrylate end groups. Dice similarity coefficient (DSC) used evaluate characterization before deformation after restoration. In addition, degree of adhesion surface...
Atlas-based auto-segmentation (ABS) procedure used in radiotherapy can be classified into two groups, one using atlas per patient (sSM) and the other multiple atlases (sMM). This study evaluated auto-contouring accuracy contouring time patients with prostate cancer procedures. The Dice similarity coefficient of sMM was significantly better than that sSM (prostate [median, 0.81 (range, 0.66–0.91) vs. 0.64 (0.27–0.71), p < 0.01], seminal vesicles [0.49 (0.31–0.80) 0.18 (0.01–0.60), 0.05],...
Abstract Background This study aimed to investigate preoperative spirometry and BMI as early predictors of the mean heart lung dose (MHD, MLD) in deep inspiration breath-hold (DIBH) radiotherapy. Methods Left-sided breast cancer patients underwent breast-conserving surgery followed by DIBH radiotherapy enrolled. Patients who were not available for excluded. One hundred eligible performed free-breathing (FB-) CT DIBH-CT plan comparison. We completed correlative multivariate analysis develop...
Deep-inspiration breath-hold radiotherapy (DIBH-RT) to reduce the cardiac dose irradiation is widely used but some patients experience little or no reduction. We constructed and compared two prediction models evaluate usefulness of our new synthetic DIBH-CT (sCT) model. Ninety-four left-sided breast cancer (training cohort: n = 64, test 30) underwent both free-breathing DIBH planning. The U-Net-based sCT generation model was developed create treatment plan. A linear for comparison by...
Abstract This study aimed to develop a poly-ε-caprolactone (PCL) material that has low melting point while maintaining the deformation ability. The new PCL (abbreviated as 4b45/2b20) was fabricated by mixing two types of with different molecular weights, numbers branches, and physical properties. To investigate point, crystallization temperature, elastic modulus, elongation at break for 4b45/2b20 three commercially available masks, differential scanning calorimetry tensile tests were...
Abstract Objective We aimed to evaluate recent trends in characteristics and treatments among patients with brain metastases clinical practice. Methods All newly diagnosed during 2016–2021 at a single cancer center were enrolled. collected the detailed features of each patient estimated number candidates considered meet following criteria used common trials: Karnofsky performance status ≥ 70 mutated non-small cell lung cancer, breast or melanoma. The classified as follows: (i) stereotactic...
Pancreatic β-cells are interconnected by gap junctions, which allow small molecules to pass from cell cell. In spite of the importance junctions in cellular communication, modeling studies have been limited complexity system. Here, we propose a mathematical junction model that properly takes into account biological functions, and apply this study β-cell cluster. We consider both electrical metabolic features Then, find when fraction ATP-sensitive K+ channels damaged, robust insulin secretion...