A5054843742- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- SARS-CoV-2 and COVID-19 Research
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- COVID-19 Clinical Research Studies
- Amyotrophic Lateral Sclerosis Research
- BRCA gene mutations in cancer
- Child Nutrition and Feeding Issues
- Colorectal Cancer Screening and Detection
- Reproductive biology and impacts on aquatic species
- Global Cancer Incidence and Screening
- Aquaculture Nutrition and Growth
- Congenital heart defects research
- Nutritional Studies and Diet
- Aging and Gerontology Research
- Cholinesterase and Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Porphyrin Metabolism and Disorders
- RNA regulation and disease
- Ethics in Clinical Research
- Celiac Disease Research and Management
- Genetic factors in colorectal cancer
- SARS-CoV-2 detection and testing
University of the Faroe Islands
1994-2024
Foundation for Agronomic Research
2015
Akvaforsk Genetics Center (Norway)
1990
Atlantic salmon ( Salmo salar ) raised under production conditions were sampled periodically during their life cycle, in fresh and salt water, to determine proximate elemental composition. The parameters changed relation cycle stage fish size, influenced by whether the or freshwater. Measurements presented can be used assist formulation of feeds, health nutritional status commercially reared salmon.
The number of genes associated with autism is increasing, but few studies have been performed on epidemiological cohorts and in isolated populations. Here, we investigated 357 individuals from the Faroe Islands including 36 autism, 136 their relatives 185 non-autism controls. Data SNP array whole exome sequencing revealed that had a higher burden rare exonic copy-number variants altering (deletions (p = 0.0352) or duplications 0.0352)), inbreeding status 0.023) load homozygous deleterious...
Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in cross-sectional population-based study the Faroe Islands. The case group consisting of total population cohort 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and 77 parents, also healthy age gender matched comparisons. There was trend males having...
We report for the first time an autosomal recessive inborn error of de novo purine synthesis (DNPS)-PAICS deficiency. investigated two siblings from Faroe Islands born with multiple malformations resulting in early neonatal death. Genetic analysis affected individuals revealed a homozygous missense mutation PAICS (c.158A>G; p.Lys53Arg) that affects structure catalytic site bifunctional enzyme phosphoribosylaminoimidazole carboxylase (AIRC, EC 4.1.1.21)/phosphoribosylaminoimidazole...
Abstract Bipolar disorder affects about 1% of the world’s population, and its estimated heritability is 75%. Only few whole genome or whole-exome sequencing studies in bipolar have been reported, no rare coding variants yet robustly identified. The use isolated populations might help finding with a recent origin, more likely to drifted higher frequency by chance. Following this approach, we investigated 28 cases 214 controls from Faroe Islands exome sequencing, results were followed-up...
Abstract Background The durability of SARS‐CoV‐2 antibody response and the resulting immunity to COVID‐19 is unclear. Objectives To investigate long‐term humoral SARS‐CoV‐2. Methods In this nationwide, longitudinal study, we determined in 411 patients aged 0–93 years from two waves infections (March December 2020) contributing 1063 blood samples. Each individual had drawn on 4–5 occasions 1–15 months after disease onset. We measured total anti‐SARS‐CoV‐2 receptor‐binding domain (RBD) using a...
Abstract Objective The occurrence of thyroid disease varies among populations. While the iodine nutrition level Faroese seems to have been decreasing over past decades, there is no systematic evaluation pattern in Faroe Islands. Such knowledge North Atlantic region may support healthcare planning and prevention. To investigate incidence rates, including subtypes diseases, demographic characteristics patients Islands, improve understanding patterns trends these disorders. Design Method A...
The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population-based register study found the 2010-2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person-years (95% confidence interval [CI], 3.3-7.0) age- sex-standardized (US 2010 Census Population) 4.1/100,000 CI, 2.7-6.0), which is a 68% increase 1987-2009 estimate. 2020 prevalence 9.5/100,000 3.0-19.6) in 52,912 inhabitants....
Childhood autism or spectrum disorder (ASD) has been regarded as one of the most stable diagnostic categories applied to young children with psychiatric/developmental disorders. The stability over time a diagnosis ASD is theoretically interesting and important for various clinical reasons. We studied from childhood early adulthood in Faroe Islands: total school age population sample (8–17‐year‐olds) was screened diagnostically assessed AD 2002 2009. This paper compares both independent...
Long-term collection of dried blood spot (DBS) samples through newborn screening may have retrospective and prospective advantages, especially in combination with advanced analytical techniques. This work concerns whether linked-reads overcome some the limitations short-read sequencing DBS samples, such as performing molecular phasing. We performed whole-exome DNA extracted from corresponding whole (WB) reference belonging to a trio unaffected parents proband affected by primary carnitine...
Abstract Here we present results from FarGen Phase I exomes. This dataset is based on the cohort, which consists of 1,541 individuals isolated population Faroe Islands. The purpose this cohort to serve as a reference catalog coding variants, and conduct genetic studies better understand contribution various diseases in Faroese population. first whole-exome data set comprise 465 total 148,267 variants were discovered. Principle Component Analysis indicates that weakly structured. distribution...
Reports of a positive family history alopecia areata (AA) have led to the assumption genetic component. The Faroe Islands population is small, has been isolated until 20th century, and served by only one dermatology clinic, making it highly suitable for genealogical studies.To determine incidence AA estimate recurrence risk ratio (RRR) in five generations nationwide dermatologist-based cohort using Faroese genealogy database.All registered cases during period 1973-2011 were identified from...
Purpose: In this paper, we present age-standardized cancer incidence and mortality rates in the Faroe Islands. We also compare with Nordic show rate ratios (IRR) (MRR).Materials methods: The Faroese registry (FCR) was established 1994, available from 1960 1983. FCR is a part of NORDCAN collaboration, where different countries all report anonymized data by standardized methods, ensuring comparability. Validation efforts revealed that 13% cases had not been reported to 2006 2019, emphasizing...
In the Faroe Islands, a clustering of amyotrophic lateral sclerosis (ALS) was observed on geographically isolated island, Suðuroy. This study aims to estimate frequency familial ALS (fALS) in Faroes including 43 patients diagnosed with ALS. Patients fALS were identified through medical records and Faroese Multi Generation Register. Firstly, recognized when occurring between first- or second-degree relatives. Secondly, families individuals pedigrees (≥3 cases within 3 generations). The...
Abstract Only a few studies have assessed the long-term duration of humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this nationwide longitudinal study from Faroe Islands with close to full participation all individuals on PCR confirmed COVID-19 during two waves infections in spring and autumn 2020 (n=172 & n=233), samples were drawn at three time points (3, 7 12 months 1, 3 after disease onset, respectively). Serum was analyzed direct...
The Faroe Islands are home to 50,000 genetically isolated people in the North Atlantic. prevalence of open-angle glaucoma (OAG) Faroese population is unknown. Consequently, we conducted a survey determine OAG population. We also investigated role known glaucoma-causing genes OAG.We prospective and newly diagnosed patients at National Hospital, Landssjukrahusid, Tórshavn between October 1, 2015 December 31, 2017. In addition reviewed only eye care provider by scrutinizing electronic medical...
The Faroe Genome Project (FarGen) explores the genetic variation within isolated population of Islands. FarGen is an open bioresource comprising 3% entire Faroese population, available for further investigation both rare and common diseases. 1,541 volunteers include representatives from all sub-regions islands, health- socio-demographic data collected by questionnaire, Multi-Generation Registry, Diagnostic-Registry, National Registry. FarGeninfrastructure already to research teams, being...
Background: The demographic history of the Faroe Islands makes this isolated population – founded in 9th century interesting for genetic research. goal FarGen project was to recruit individuals infrastructure promote research into features Faroese people, and develop a reference panel population-specific variants. We aimed 1500 individuals. Participation voluntary; participants had donate blood sample whole-genome sequencing, answer questionnaire regarding sociodemographics, health,...
Gregersen, Noomi O.; Lydersen, Leivur N.; Biskopstø, Marjun; Zachariasen, Julia F.; Jespersen, Rókur Stórá, Tórmóður; Andorsdóttir, Guðrið; Wang, August G. Author Information
As sustained development in cancer treatment protocols have led to improved survival most areas of the world, surveillance is needed ensure that small populations follow suit. Our study reports age-standardized relative Faroe Islands compared other Nordic countries. We present 1- and 5-year estimates corresponding 95% confidence intervals for compare them with The data this article has been obtained through NORDCAN collaboration (2019 data). Age-standardized was estimated using shared R...
This study is the first report regarding childhood cancer in Faroe Islands and describes incidence survival of over last 60 years Islands.
The presence of malnutrition is increasingly becoming a postdischarge problem in surgical patients. We aimed to investigate whether oral nutritional supplements combined with resistance training could minimize skeletal muscle atrophy patients after discharge. This randomized controlled study was conducted at the Department Surgery, National Hospital Faroe Islands from 2018 2020. A total 45 aged 37−74 years participated and were allocated one three groups: diet (DI; n = 13), exercise (EX +...