Aspiration-assisted bioprinting enables precise positioning of viscoelastic spheroids in both scaffold-based and free manner.

It is shown that the covariance operator of a locally stationary process has approximate eigenvectors are local cosine functions. We model processes with pseudo-differential operators time-varying convolutions. An adaptive estimation calculated by searching first for "best" basis which approximates band or diagonal matrix. The obtained from regularized versions coefficients in best basis.

Various lab on a chip devices have been developed recently to detect and separate circulating tumour cells (CTCs) for early stage cancer detection. Because CTCs are extremely rare in the blood, next generation CTC microfilters aim at significant improvement both efficiency throughput. based cell deformability seem be promising direction. In present research, we study passing event through micro-filtering channel with various 3D geometries. The pressure signatures different types of channels...

Abstract Bioprinting of cellular aggregates, such as tissue spheroids, to form three-dimensional (3D) complex-shaped arrangements, has posed a major challenge due lack robust, reproducible and practical bioprinting techniques. Here, we demonstrate 3D aspiration-assisted freeform spheroids by precisely positioning them in self-healing yield-stress gels, enabling the self-assembly for fabrication tissues. The presented approach enables traverse directly from cell media gel on demand. We study...

Abstract The existing Al-Si-Cu-Mg alloys cannot meet the needs of new energy automobile parts with low cost and high performance due to difficulty in reconciling strength plasticity. In this study, a systematic research method combining thermodynamic calculation experiment was adopted, alloy composition, microstructure mechanical properties Al-9Si-2.5Cu-0.5Mg were investigated by adjusting content Cu, Mg heat treatment process. results show that, as Cu increase, increases first then...

Three-dimensional (3D) printing technology is increasingly being employed in biochemical as well clinical applications and more importantly fabrication of microfluidic devices. However, the community mainly relies on photolithography for a defined mask, which both tedious expensive requiring clean room settings limited to generation two-dimensional (2D) features. In this work, we 3D printed nanoclay-reinforced Pluronic ink sacrificial material, exhibited shear thinning behavior superior...

Models of a droplet passing through narrow constrictions have wide applications in science and engineering. In this paper, we report our findings on the minimum impulse (momentum change) pushing circular constriction. The existence is mathematically derived numerically verified. happens at critical velocity when time-averaged Young-Laplace pressure balances total minor loss Finally, numerical simulations are conducted to verify these concepts. These results could be relevant problems energy...

In this study, Al-Mg alloys were prepared by vacuum + argon-protected casting. The effects of Sc microalloying on the microstructure and mechanical properties alloy studied. strengthening mechanism with was discussed. results show that average grain size as-cast reaches 36.07 μm, which is 74.4% smaller than 1 without refiner 32.0% 2 0.15% Ti. has excellent comprehensive properties, a tensile strength 274 MPa an elongation 29.67%, its 10.6% higher 7.9% 2. There exist two kinds fine particles...

Uniform direct chill (UDC) casting method was developed by combining annular electromagnetic stirring (A-EMS) with intercooling in casting. In order to investigate effect of UDC on flow patterns, temperature profiles and solidification during the casting, a numerical model process used simulate for preparing 7005 aluminum alloy billets. The comparison calculated results normal (NDC) indicated that sump depth are modified remarkably application profile history casing were studied, mechanism...

In this study, large-sized Al–Zn–Mg–Cu alloy billets were prepared by direct chill casting imposed with annular electromagnetic stirring and intercooling; a process named uniform casting. The effects of on grain size the alloying element distribution investigated compared those normal method. results show that microstructures refined homogeneity elements was greatly improved imposing intercooling. casting, explosive nucleation can be triggered, originating from mold wall dendrite fragments...

Cartilage defects caused by mechanical tear and wear are challenging clinical problems. Articular cartilage has unique load-bearing properties limited self-repair ability. The current treatment methods, such as microfractures autogenous transplantation to repair full-thickness defects, have apparent limitations. Tissue engineering technology the potential directs research development. To enhance regenerative capacities of in weight-bearing areas, we attempted develop a biomimetic scaffold...

The model of a droplet squeezed through narrow-constricted channel has many applications in pathology, chip/filter/membrane design, drug delivery, etc. Understanding the transient physics squeezing process is important design and optimization micro flow systems. However, available models often ignore influence viscosity, they usually feature low numerical efficiency by solving Navier-Stokes equations. In present research, we developed low-dimension analytical to predict pressure viscous...

This study presents a modified annular electromagnetic stirring (M-AEMS) melt treatment suitable for large-volume and high-alloyed aluminum alloy. A 3D computational model coupling an with macroscopic heat fluid-flow was established by using Ansoft Maxwell Fluent from ANSYS workbench, the effects of shielding ring, height magnet yoke, shape iron core, internal cooling mandrel on electromagnetic, thermal flow fields were studied numerically. Based optimal technical parameters, effectivity...

Detection and capture of circulating tumor cells (CTCs) with microfluidic chips hold significance in cancer prognosis, diagnosis, anti-cancer treatment. The counting CTCs provides potential tools to evaluate stages as well treatment progress. However, facing the challenge rareness blood, precise enumeration is challenging. In present research, we designed an inertial-deformability hybrid chip using a long spiral channel trapezoid-circular pillars zone. To clinically validate device, has been...

Oscillating bubbles have proven to be a versatile tool for various microfluidic applications. Despite the existence of extensive literature on behavior acoustically actuated bubbles, ready-to-use approach, capable predicting oscillatory motion trapped in circular microcavities, is still missing. In this study, we propose theoretical model quantify resonant frequencies and viscous dissipation factors single bubble verify it experimentally. We further investigate an interaction two coupled...

Abstract Coarse microstructures and severe macrosegregation always occur in large-sized billets prepared by normal direct chill casting, cannot be eliminated during subsequent deformation or high temperature annealing. This study proposes a new melt treatment method coupled to annular electromagnetic stirring intercooling, applies it casting of 2219 aluminum alloy billets. Compared the microstructure second phase were refined homogenized, Cu was alleviated. Accordingly, average tensile yield...

The nucleation and grain growth that occur during solidification have been extensively examined, but insight into the influence of an external field on formation heterogeneous crystal nuclei above liquidus remains unclear in peritectic refinement mechanism. In this work, we studied effect cooling rate primary Al3Zr Al-0.2%Zr alloys with inter-cooling annular electromagnetic stirring (IC-AEMS). results show size distribution are greatly improved, morphology transformed from large plate/blocky...