A5069265356- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Immunotherapy and Immune Responses
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Nanofabrication and Lithography Techniques
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Olfactory and Sensory Function Studies
- Christian Theology and Mission
- Religion, Society, and Development
- Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Religious Freedom and Discrimination
- Human-Animal Interaction Studies
- Cardiac electrophysiology and arrhythmias
- Nanoparticles: synthesis and applications
- T-cell and B-cell Immunology
- Sarcoma Diagnosis and Treatment
Arsenal Biosciences (United States)
2022-2024
University of California, San Francisco
2016-2020
Howard Hughes Medical Institute
2016-2020
University of Chicago
2007-2016
Despite decades of research with humans, the biological mechanisms that motivate an individual to help others remain poorly understood. In order investigate roots pro-sociality in mammals, we established helping behavior test, a paradigm which rats are faced conspecific trapped restrainer can only be opened from outside. Over course repeated test sessions, exposed cagemate learn open door restrainer, thereby rat escape (Ben-Ami Bartal et al., 2011). The discovery this natural provides unique...
A logic to cell-cell recognition There has been exciting progress in the field of cancer immunotherapy, which harnesses a patient's own immune system kill cells. However, achieving precise cells remains challenging. Cells engineered with synthetic Notch (synNotch) receptors bind specific antigens, and binding induces expression defined genes. Williams et al. used synNotch modules as transcriptional connectors that daisy-chain together multiple receptors. They T can recognize up three target...
T cells engineered to recognize and kill tumor have emerged as powerful agents for combating cancer. Nonetheless, our ability engineer remains relatively primitive. Aside from CAR treating B cell malignancies, most therapies are risky, toxic, often ineffective, especially those that target solid cancers. To fulfill the promise of cell-based therapies, we must transform engineering into a systematic predictable science by applying principles tools synthetic biology. Synthetic biology uses...
Abstract Despite decades of research with humans, the biological mechanisms that motivate an individual to help others remain poorly understood. In order investigate roots pro-sociality in mammals, we established helping behavior test, a paradigm which rats are faced conspecific trapped restrainer can only be opened from outside. Over course repeated test sessions, exposed cagemate learn open door restrainer, thereby rat escape (Ben-Ami Bartal et al., 2011). The discovery this natural...
Advanced biomaterials provide versatile ways to spatially and temporally control immune cell activity, potentially enhancing their therapeutic potency safety. Precise modulation demands multi-modal display of functional proteins with controlled densities on biomaterials. Here, we develop an artificial engager (AICE) platform – biodegradable particles onto which multiple are densely loaded ratiometric via short nucleic acid tethers. We demonstrate the impact AICE varying ratios anti-CD3...
Abstract CAR T cell activity in solid tumors is limited by off-tumor toxicity and functional suppression from the tumor microenvironment (TME). To address these challenges, we have developed AB-1015, an autologous ICT product intended for use ovarian cancer. AB-1015 incorporates two modules: an” AND” logic gate designed to limit through dual antigen recognition, a shRNA-miR targeting FAS PTPN2 resist TME improve function. The consists of priming receptor (PrimeR) against ALPG/P inducible...
Abstract CAR T cell activity in solid tumors is limited, part, by off-tumor toxicity. To address this obstacle, AB-1015 contains an “AND” logic gate, consisting of a priming receptor (PrimeR) and inducible chimeric antigen (CAR) that upregulated PrimeR activation. The gate targets ALPG/P MSLN, which are coexpressed ovarian but not normal tissues. induction within the tumor expected to be dynamic process influenced multiple factors, including density, target abundance, as well...
<h3>Background</h3> CAR T cell activity in solid tumors is limited by off-tumor toxicity, antigen heterogeneity, poor persistence, and functional suppression resulting from the tumor microenvironment (TME). To address these challenges, we have developed AB-1015, an autologous, integrated circuit (ICT) product for potential treatment of ovarian cancer. The AB-1015 DNA cassette includes two modules: 'AND' logic gate targeting ALPG/P MSLN designed to limit toxicity through dual recognition, a...
Abstract Advanced biomaterials can be used to spatially and temporally control immune cell activities improve the efficacy safety of therapies. Precise modulation demands multi-modal display functional proteins on with a high level control. Here, we developed biodegradable engaging particles (ICEp) synthetic short DNA as scaffolds for efficient tunable protein loading. We demonstrate precise ratiometric anti-CD3 anti-CD28 antibodies this platform impact quality ex vivo expanded human primary...
Abstract CAR T cell therapies for solid tumors are limited by a paucity of tumor-specific single target antigens and insufficient potency due to limitations biology. Logic gated (LG) CARs increase control therapy activation killing requiring recognition two or more through AND AND-NOT Boolean logic. They represent an attractive strategy improve the therapeutic index increasing specificity tumor antigens. We created logic gate cassette deliverable CRISPR-mediated, non-viral, site-specific...