A5052312865- Preterm Birth and Chorioamnionitis
- Chemical Synthesis and Analysis
- Infant Nutrition and Health
- Reproductive Physiology in Livestock
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
- Urinary Tract Infections Management
- Human-Animal Interaction Studies
- Protein Kinase Regulation and GTPase Signaling
- Birth, Development, and Health
- Radio, Podcasts, and Digital Media
- Mechanical Circulatory Support Devices
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Social Media in Health Education
- Medical Malpractice and Liability Issues
- Neuroendocrine regulation and behavior
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Blood groups and transfusion
- Pregnancy and preeclampsia studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infant Health and Development
- Complement system in diseases
Jamaica Hospital
2009-2018
Cornell University
1993-2017
Weill Cornell Medicine
2017
Creedmoor Psychiatric Center
2016
Oxford Instruments (United Kingdom)
2016
Edendale Hospital
2013
University of Oxford
2009-2011
The University of Adelaide
2004-2006
NewYork–Presbyterian Hospital
1993-2000
Lincoln Medical Center
1997
β-Lactam antibiotics have long been a treatment of choice for bacterial infections since they bind irreversibly to Penicillin-Binding Proteins (PBPs), enzymes that are vital cell wall biosynthesis. Many pathogens express drug-insensitive PBPs rendering β-lactams ineffective, revealing need new types PBP inhibitors active against resistant strains. We identified alkyl boronic acids including methicillin-resistant S. aureus (MRSA). The crystal structures PBP1b complexed 11 different boronates...
The Src Homology 3 (SH3) domains are small protein-protein interaction that bind proline-rich sequences and mediate a wide range of cell-signaling other important biological processes. Since deregulated signaling pathways form the basis many human diseases, SH3 have been attractive targets for novel therapeutics. High-affinity ligands designed; however, these all peptide-based no examples entirely nonpeptide previously reported. Using mouse Tec Kinase domain as model system structure-based...
Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are targets for β-lactam antibiotics. Non-β-lactam based antibiotics that target PBPs interest because bacteria have evolved resistance to Boronic acids been developed as inhibitors mechanistically related serine β-lactamases proteases; however, they not explored extensively PBP inhibitors. Here we report aromatic boronic acid d,d-carboxypeptidase R39 from Actinomadura sp. strain. Analogues an...
Podcasts are increasingly being recognized as an effective platform to facilitate the continuous professional development (CPD) of health care professionals (HCPs). Compared with face-to-face meetings and other more traditional forms CPD, podcasts allow for flexible learning less expensive develop. at cutting edge digital education can be important element a pharmaceutical company's multichannel communications plan improve HCP engagement CPD in specific therapy areas. However, developing...
We analyzed whether specimens obtained from the vaginal introitus were comparable to endocervical and posterior vault for detection of Chlamydia trachomatis Trichomonas vaginalis by polymerase chain reaction.Introital 300 women at first prenatal visit. Specimens also 219 these patients. All samples tested C. T. reaction.C. was identified in endocervices 36 (12.0%); all but one none endocervical-negative positive this organism introitus. detected 22 (10.0%); organism. Compared with reaction,...
Following from the evaluation of different types electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors a penicillin binding protein. The results suggest that structurally informed approach protein inhibition will be useful for development both improved reversibly inhibitors, including acids, acylating such as β-lactams.
Trichomonas vaginalis vaginal infections are often both asymptomatic and difficult to detect by current methods. We evaluated the ability of a newly developed polymerase chain reaction (PCR) assay identify T. in samples from pregnant non-pregnant women.In 1st study, we compared prevalence detection PCR culture using Diamond's medium 52 women with symptoms infection. In 2nd was detected wet mount microscopy 131 women.Among vaginitis, 7 (13.5%) were PCR-positive for vaginalis. Six women, but...
A study was undertaken in 372 consecutive patients undergoing non-elective cesarean delivery to explore the incidence and nature of conflicts between physician patient surrounding decision undergo delivery; examine adequacy informed consent at time describe importance a preventive ethics approach delivery. During 6-month interval, all who underwent their physicians were asked take part survey early postpartum period concerning response recommendations for The included demographics as well...
Maternal behavior, such as licking and cleaning of the newborn, oral consumption placenta membranes is characteristic nearly all mammals. They are first step toward maternal acceptance bonding in canines. Factors affecting these initial behaviors unclear. Also impact regard to establishing long-term newborn We undertook this study determine role amniotic fluid on newborns development maternal-newborn relationship. Thirty litters were studied, nine serving controls which neonatal simply...
Larger volume intravascular transfusions to manage severe maternal red cell alloimmunization in pregnancy may prolong the interval between procedures without increasing maternal, fetal, or neonatal complications. A retrospective cohort study compared management and outcome of 19 patients with managed at two facilities different transfusion protocols. The blood transfused, pre- post-transfusion fetal hematocrit, (days) were compared. respective results transfused per procedure post- but not...
There is a need for rapid, uncomplicated, and inexpensive test Chlamydia trachomatis infection in women. We evaluated the ability of 6-min enzyme-linked immunosorbent assay (ELISA) that requires no laboratory equipment (IgA Rapid SeroTest; Savyon Diagnostics) to detect C. immunoglobulin A (IgA) endocervices 167 inner-city pregnant women compared results with DNA amplification (Amplicor PCR; Roche antigen detection (Chlamydiazyme; Abbott Laboratories) performed on same Anti-C. IgA was...
Maternal behavior, such as licking and cleaning of the newborn, oral consumption placenta membranes is characteristic nearly all mammals. They are first step toward maternal acceptance bonding in canines. Factors affecting these initial behaviors unclear. Also impact regard to establishing long-term newborn We undertook this study determine role amniotic fluid on newborns development maternal-newborn relationship. Thirty litters were studied, nine serving controls which neonatal simply...
INTRODUCTION: Centering or group pregnancy, has been shown to have an impact on reduction of preterm births. The the health education and support weight gain poorly studied. A centering pregnancy (CP) participants were assessed for patterns loss in urban inner city community teaching hospital. METHODS: retrospective chart review was performed a prospectively maintained database CP. RESULTS: One-hundred-forty-six patients offered CP, their charts reviewed. total 72 did not continue...
Preterm delivery is the leading cause of perinatal morbidity and mortality worldwide. Despite a great deal research into this disease, we still do not understand its pathophysiology. Our treatments for disease are only marginally effective. Biochemical markers were developed with hope giving us new tools to prevent preterm deliveries. Specifically was that they could predict which patients destined have delivery. At present time these perform satisfactorily at predicting labor. They...
Preterm delivery is the leading cause of perinatal morbidity and mortality worldwide. Despite a great deal research into this disease, we still do not understand its pathophysiology. Our treatments for disease are only marginally effective. Biochemical markers were developed with hope giving us new tools to prevent preterm deliveries. Specifically was that they could predict which patients destined have delivery. At present time these perform satisfactorily at predicting labor. They...