A5049748413- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Anatomy and Medical Technology
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Neuropeptides and Animal Physiology
- Proteoglycans and glycosaminoglycans research
- Neuroendocrine Tumor Research Advances
- Nail Diseases and Treatments
- Advanced MRI Techniques and Applications
- Anesthesia and Sedative Agents
- Neonatal and fetal brain pathology
- Generative Adversarial Networks and Image Synthesis
- Colorectal and Anal Carcinomas
- Advanced NMR Techniques and Applications
- Functional Brain Connectivity Studies
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Autopsy Techniques and Outcomes
Roche (Switzerland)
2025
Ghent University Hospital
2017-2024
Scuola Normale Superiore
2020-2024
Ghent University
2019-2024
National Research Council
2023-2024
University of Verona
2021-2022
Sapienza University of Rome
2015-2022
Policlinico Umberto I
2022
Perineuronal nets (PNNs) surround specific neurons in the brain and are involved various forms of plasticity clinical conditions. However, our understanding PNN role these phenomena is limited by lack highly quantitative maps distribution association with cell types. Here, we present a comprehensive atlas Wisteria floribunda agglutinin (WFA)-positive PNNs colocalization parvalbumin (PV) cells for over 600 regions adult mouse brain. Data analysis shows that PV expression good predictor...
Abstract Synaptic dysfunction is an early mechanism in Alzheimer’s disease that involves progressively larger areas of the brain over time. However, how it starts and propagates unknown. Here we show amyloid-β released by microglia association with large extracellular vesicles (Aβ-EVs) alters dendritic spine morphology vitro, at site neuron interaction, impairs synaptic plasticity both vitro vivo entorhinal cortex–dentate gyrus circuitry. One hour after Aβ-EV injection into mouse cortex,...
ABSTRACT The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, main endpoints of “foot slip counts” “time cross” are prone human‐rater variability offer limited sensitivity specificity. We asked if machine learning–based methods could reveal previously hidden, but biologically relevant, insights from task. Marker‐less pose estimation, using DeepLabCut, was deployed label 13 anatomical key points on mice traversing beam. Next, we...
Abstract Perineuronal nets (PNNs) surround specific neurons in the brain and are involved various forms of plasticity clinical conditions. However, our understanding PNN role these phenomena is limited by lack highly quantitative maps distribution association with cell types. Here, we present first comprehensive atlas (in Allen Brain Atlas coordinates) colocalization parvalbumin (PV) cells for over 600 regions adult mouse brain. Data analysis showed that PV expression a good predictor...
Abstract β-Amyloid is one of the main pathological hallmarks Alzheimer’s disease and plays a major role in synaptic dysfunction. It has been demonstrated that β-amyloid can elicit aberrant excitatory activity cortical-hippocampal networks, which associated with behavioural abnormalities. However, mechanism spreading action within specific circuitry not elucidated yet. We have previously motion microglia-derived large extracellular vesicles carrying β-amyloid, at neuronal surface, crucial for...
Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute Alzheimer's disease (AD) and be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH metabolism, gained interest its ability promote learning memory the mouse. Moreover, T1AM has demonstrated rescue β-Amyloid dependent LTP impairment entorhinal cortex (EC), brain area crucially involved early affected during AD. In present work, we...
Abstract The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, main endpoints of ‘foot slip counts’ ‘time cross’ are prone human-rater variability offer limited sensitivity specificity. We asked if machine learning-based methods could reveal previously hidden, but biologically relevant, insights from task. Marker-less pose estimation, using DeepLabCut, was deployed label 13 anatomical points on mice traversing beam. Next, we...
Ultrasonography (US) of the nail is raising interest in last years and its feasibility, quickness amount descriptive data may provide valuable information. Different authors presented several scanning approaches to complex different pathological conditions, such as psoriasis, but no protocol was ever proposed using healthy subjects population reference. The aim study establish a for US plate assess whether measurement influenced by longitudinal vs transverse scan, sex, digit hand dominance....
Vascular reperfusion of Thiel cadavers can aid surgical and anatomical instruction. This study investigated whether ideal embalming circumstances provide lifelike vascular flow, enabling practice enhancing reality.Pressure-controlled pump-driven administration blue solution was assessed directly postmortem in a pig model (n = 4). Investigation subsequent injection red paraffinum perliquidum (PP) included assessment flow parameters, intracorporeal distribution, alterations, feasibility for...
e13616 Background: Laparoscopic staging of abdominal cancer is routinely performed to assess the presence peritoneal metastasis (PM). One major challenge laparoscopic ability distinguish between a malignant and benign lesion, particularly scar tissue. Lesions' recognition subjective intra-case variability, surgeons' experience, type primary tumor response systemic chemotherapy. The Peritoneal Regression Grading Score (PRGS) offers an objective histologic evaluation biopsied lesion by...