A5033904435- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Proteoglycans and glycosaminoglycans research
- Histone Deacetylase Inhibitors Research
- Diet, Metabolism, and Disease
- Sexual Differentiation and Disorders
- Gastrointestinal motility and disorders
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Muscle metabolism and nutrition
- Genetic Neurodegenerative Diseases
Scuola Normale Superiore
2021-2024
Perineuronal nets (PNNs) surround specific neurons in the brain and are involved various forms of plasticity clinical conditions. However, our understanding PNN role these phenomena is limited by lack highly quantitative maps distribution association with cell types. Here, we present a comprehensive atlas Wisteria floribunda agglutinin (WFA)-positive PNNs colocalization parvalbumin (PV) cells for over 600 regions adult mouse brain. Data analysis shows that PV expression good predictor...
Exposing animals to an enriched environment (EE) has dramatic effects on brain structure, function, and plasticity. The poorly known "EE-derived signals'' mediating the EE are thought be generated within central nervous system. Here, we shift focus body periphery, revealing that gut microbiota signals crucial for EE-driven Developmental analysis reveals striking differences in intestinal bacteria composition between standard rearing (ST) mice, as well enhanced levels of short-chain fatty...
Abstract Perineuronal nets (PNNs) surround specific neurons in the brain and are involved various forms of plasticity clinical conditions. However, our understanding PNN role these phenomena is limited by lack highly quantitative maps distribution association with cell types. Here, we present first comprehensive atlas (in Allen Brain Atlas coordinates) colocalization parvalbumin (PV) cells for over 600 regions adult mouse brain. Data analysis showed that PV expression a good predictor...
Creatine Transporter Deficiency (CTD) is an X-linked disease due to the loss of SLC6A8 gene and presenting with low brain creatine, intellectual disability, autistic-like behavior seizures. No treatments are available yet for CTD, little known about circuit alterations underlying its pathological endophenotypes. Here, we tracked network behavioral dysfunction in a murine model CTD at two stages progression. fMRI mapping revealed widespread disruption connectivity Slc6a8-KO mutants, prominent...
Cyclin-Dependent Kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare X-linked developmental encephalopathy caused by pathogenic variants of the CDKL5 gene. In addition to diverse range neurological symptoms, CDD patients frequently manifest gastrointestinal (GI) issues and subclinical immune dysregulation. This comorbidity suggests potential association with intestinal microbiota, prompting an investigation into whether gut dysbiosis contributes severity both GI symptoms. We examined...
ABSTRACT Background Cyclin-Dependent Kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare X-linked developmental encephalopathy caused by pathogenic variants of the CDKL5 gene. In addition to diverse range neurological symptoms, CDD patients frequently manifest gastrointestinal (GI) issues and subclinical immune dysregulation. This comorbidity suggests potential association with intestinal microbiota, prompting an investigation into whether gut dysbiosis contributes severity both GI...
Among Histone post-translational modifications (PTMs), lysine acetylation plays a pivotal role in the epigenetic regulation of gene expression, mediated by chromatin modifying enzymes. Due to their activity physiology and pathology, several chemical compounds have been developed inhibit function these proteins. However, pleiotropy classes proteins represents weakness drugs. Ideally, new generation drugs should target with molecular precision individual acetylated lysines on protein. We...
ABSTRACT Exposing animals to an enriched environment (EE) has dramatic effects on brain structure, function and plasticity. The poorly known “EE derived signals” mediating the EE are thought be generated within central nervous system. Here, we shift focus body periphery, revealing that gut microbiota signals crucial for EE-driven Developmental analysis of intestinal bacteria composition in mice revealed striking differences from standard condition (ST) enhanced levels short-chain fatty acids...
Abstract Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be signaling molecule regulating gene transcription. Thus, we assessed lysine beta-hydroxybutyrylation (K-bhb) levels in proteins extracted from cerebral cortex mice undergoing ketogenic challenge (48 hrs fasting). We found that fasting enhanced K-bhb variety including histone H3. ChIP-seq experiments showed K9 H3 (H3K9-bhb) was significantly...
ABSTRACT Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be signaling molecule regulating gene transcription. Thus, we assessed lysine beta-hydroxybutyrylation (K-bhb) levels in proteins extracted from cerebral cortex mice undergoing ketogenic challenge (48 hrs fasting). We found that fasting enhanced K-bhb variety including histone H3. ChIP-seq experiments showed K9 H3 (H3K9-bhb) was significantly...