A5001771481- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- TGF-β signaling in diseases
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Brain Metastases and Treatment
- Lymphatic System and Diseases
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biomarkers in Disease Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Congenital Anomalies and Fetal Surgery
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
Memorial Sloan Kettering Cancer Center
2023
Johns Hopkins University
2020-2023
University of Baltimore
2023
Johns Hopkins Medicine
2021-2022
Indiana University School of Medicine
2015-2016
Indiana University – Purdue University Indianapolis
2013-2016
Indiana University Health
2015
Indiana University
2015
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with marked chemoresistance and a 5-year survival rate of 7%. The integrated stress response (ISR) cytoprotective pathway initiated in to exposure various environmental stimuli. We used pancreatic cells (PCCs) that are highly resistant gemcitabine (Gem) orthotopic mouse model investigate the role ISR Gem chemoresistance. induced eIF2 phosphorylation downstream transcription factors ATF4 CHOP PCCs, these effects occurred...
Abstract Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple Negative Breast Cancer (TNBC) is associated with better prognosis. However, molecular mechanisms underlying these immune cell differences are not well delineated. In this study, analysis hematoxylin and eosin images from The Genome Atlas (TCGA) breast cancer cohort failed to show a prognostic benefit TILs TNBC, whereas CIBERSORT analysis, which quantifies proportion each type, demonstrated...
Pancreatic ductal adenocarcinoma (PDAC) is often associated with overexpression of TGF-β. Given its tumor suppressor functions, it unclear whether TGF-β a valid therapeutic target for PDAC. Here, we found that proliferating pancreatic cancer cells (PCCs) from human PDAC patients and multiple murine models (mPDAC) exhibit abundant levels phosphorylated retinoblastoma 1 (RB) Smad2. TGF-β1 treatment enhanced proliferation PCCs isolated KrasG12D-driven mPDAC lacked RB (KRC cells). This mitogenic...
// Riesa M. Burnett 1 , Kelly E. Craven 2 Purna Krishnamurthy Chirayu P. Goswami 4 Sunil Badve 3 Peter Crooks 5 William Mathews 6 Poornima Bhat-Nakshatri and Harikrishna Nakshatri 1,2,4 Department of Surgery, Indiana University School Medicine, Indianapolis, IN, USA Biochemistry Molecular Biology, Pathology Laboratory Center for Computational Biology Bioinformatics, Arkansas, Little Rock, AR, Leuchemix, Inc., Woodside, CA, Correspondence to: Nakshatri, email: Keywords : breast cancer, brain...
// Jesse Gore 1, 5 , Kelly E. Craven 2 Julie L. Wilson 1 Gregory A. Cote 5, 6 Monica Cheng Hai V. Nguyen 3 Harvey M. Cramer 4 Stuart Sherman Murray Korc 2, Department of Medicine, Indiana University School Indianapolis, IN 46202, USA Biochemistry and Molecular Biology, Surgery, Pathology Laboratory The Melvin Bren Simon Cancer Center, the Center for Pancreatic Research, Medical South Carolina, Charleston, SC 29425, Correspondence to: Korc, e-mail: mkorc@iu.edu Gore, ajgore@iu.edu Keywords:...
// Kelly E. Craven 1, * , Jesse Gore 2, 3, Julie L. Wilson 2 Murray Korc 3 1 Departments of Biochemistry and Molecular Biology, Indiana University School Medicine, Indianapolis, IN 46202, USA Department The Pancreatic Cancer Signature Center at Simon Center, These authors contributed equally to this work Correspondence to: Gore, e-mail: ajgore@iu.edu Keywords: pancreatic cancer, TCGA, angiogenesis, TGF-β, inflammation Received: October 13, 2015 Accepted: November 08, Published: 18, ABSTRACT...
Abstract Background Cholangiocarcinoma is a rare gastrointestinal malignancy that arises within the intrahepatic, perihilar, and/or extrahepatic bile ducts. Individuals with cystic fibrosis are at increased risk for malignancies. The most common in colon cancer, but other malignancies also occur greater rates than general population. Case presentation We present case of rapidly progressive metastatic intrahepatic cholangiocarcinoma an individual who was 5 months postpartum, incidentally...
Abstract Pancreatic Ductal Adenocarcinoma (PDAC), which comprises 85% of pancreatic cancers, is the 4th leading cause cancer death in United States with a 5-year survival 7%. While human PDACs (hPDACs) are hypovascular, they also overexpress number angiogenic growth factors and receptors. Additionally, use anti-angiogenic agents murine models PDAC leads to reduced tumor volume, spread, microvessel density, improved survival. Nonetheless, clinical trials using therapy have been overwhelmingly...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that projected to become the 2nd leading cause of cancer deaths by 2030. PDACs are associated with high frequency KRAS mutations (95%) and overexpression many pro-angiogenic cytokines growth factors. Using genetically engineered mouse model (GEMM) we established in which oncogenic Kras combined loss RB (KRC), have determined arising these mice (mPDACs) harbor endothelial cells (ECs) sinusoidal-like vessels blood flow, as...
Abstract The purpose of this study was to explain a serendipitously discovered next generation sequencing (NGS) artifact. While reviewing clinical cases, we found case large deletion that also contained multiple missense mutations. This phenotype unknown several molecular pathologists in our group. We reviewed 46 cases with short insertions or deletions (InDels) (1-30 bases) FLT3 internal tandem duplications (ITDs) (6-183 solid hematologic malignancy processed NGS assay and identified...