<b><i>Background:</i></b> Treatment options for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA) include medical therapy such as ibuprofen and indomethacin surgical ligation. <b><i>Objective:</i></b> To evaluate efficacy intravenous paracetamol in preterm infants with hsPDA whose feeding was contraindicated or had intolerance. <b><i>Methods:</i></b> Preterm were started on treatment parental...

Background and objectives: Patent ductus arteriosus (PDA) is a significant cause of morbidity mortality in preterm infants. This case series was conducted to investigate the usefulness paracetamol as first choice for treatment PDA infants.Subjects methods: Preterm infants were prospectively enrolled. Treatment with oral started at dose 15 mg/kg every 6 h 3 d, echocardiographic evaluation performed end 2 d after treatment. Serum levels also evaluated 24 ensure absorption reaching therapeutic...

The most commonly used drugs for closure of a haemodynamically significant patent ductus arteriosus (hsPDA) are cyclooxygenase inhibitors, mainly indomethacin and intravenous/oral ibuprofen. In contrast to high rates, several adverse effects have been reported with such medications, including gastrointestinal bleeding perforation, weakened platelet aggregation, hyperbilirubinaemia renal failure.1 ,2 role paracetamol as an …

Objective To investigate the effect of surgery time on prognosis newborns with meningomyelocele. Methods The records neonates meningomyelocele were retrospectively analyzed. Demographic and clinical characteristics as well information, timing surgery, durations hospital stay antibiotic therapy recorded. Results 30 babies included in final analysis. Overall, mean gestational age was 37.7±2.7 weeks, a birth weight 2967±755 g head circumference 35.8±3.8 cm. In terms localization, 46.6%...

Objective: Hemodynamically significant PDA (hsPDA) is one of the most common problems in preterm infants. This study was conducted to investigate effect combined pharmacological (paracetamol + ibuprofen) therapy on monotherapy-resistant hsPDA infants.Subject and methods: The included infants with persistent hsPDA, unresponsive monotherapy. Combined treatment started as paracetamol at a dose 15 mg/kg every 6 hours for 5 days, ibuprofen an initial 10 followed by 24 48 hours. Echocardiographic...

Purpose: To determine whether prophylaxis with etanercept, an anti-inflammatory drug, would decrease the severity of lung injury in a neonatal rat model bronchopulmonary dysplasia (BPD); Materials and Methods: Rat pups were divided into three groups: exposed to room air (group 1; n = 10), hyperoxia + placebo 2; 9), etanercept 3; 8). Lung morphology was assessed by alveolar surface area percentage, which is measure size. The severities inflammation antioxidant capacity quantifying tumor...

Paraurethral cysts are rare in females, especially the neonatal period. The aetiology of congenital paraurethral is obstruction Skene's ducts from para/periurethral glands. may be totally asymptomatic, non-tender, soft, cystic, ovoid masses about 6–10 mm size and yellowish colour. These lesions discovered on either side urethral meatus during routine examination most these resolve spontaneously. This study reports two female newborns with treated needle aspiration because difficulty...

The aim of the present study was to characterize pharmacokinetic profile oral ibuprofen on consecutive 3 d by trough serum levels, and if possible define a cut-off level for ductal closure in preterm infants. enrolled 20 infants with gestational age ≤30 weeks, birth weight <1250 g hemodynamically significant patent ductus arteriosus (hsPDA). Patients received at an initial dose 10 mg/kg, followed 5 mg/kg 24 48 h. were compared levels addition their demographic clinical data case response...

Intrauterine ischemia of the limbs is a rare condition involving thrombosis and extremities before birth. The clinical presentation depends on extremity affected as well timing thrombosis. Very few cases with hypoperfusion gangrene due to intrauterine have been reported in literature, therefore there no consensus optimal therapeutic strategy for such cases. Presented here case newborn brachial arterial right upper who was successfully treated by combination recombinant tissue plasminogen...

Lethargy in newborns usually indicates central nervous system dysfunction, and many conditions such as cerebrovascular events, infections, metabolic diseases should be considered the differential diagnosis. Nonketotic hyperglycinemia is an autosomal recessive error of glycine metabolism, characterized by myoclonic jerks, hypotonia, hiccups, apnea, progressive lethargy that may progress to encephalopathy or even death. Cerebral sinovenous thrombosis a rare condition with various clinical...

Presentación de casos clínicos ResumenSe informa el caso un neonato que desarrolló encefalopatía en transcurso los primeros tres días vida.Presentaba hipo persistente, evolucionó a coma profundo 72 horas después la admisión al hospital.Los parámetros septicemia y análisis del líquido cefalorraquídeo (LCR) fueron normales.Tras evaluación metabólica, se confirmó presencia hiperamoniemia e hipercitrulinemia.El índice concentración LCR/glicina plasma era normal.Esto no coincidió con nuestro...

Case report AbstrACtWe an infant who developed encephalopathy within the first 3 days of life.He had persistent hiccups that progressed to deep coma 72 hours after admission.The sepsis parameters and cerebrospinal fluid examination (CSF) were normal.The metabolic evaluation confirmed hyperammonemia, hypercitrullinemia.The ratio CSF/plasma glycine concentration was normal.This did not agree with our initial diagnosis nonketotic hyperglycinemia where is present more often.Neonatal onset...

Aim Pulmonary hemorrhage is an important cause of morbidity and mortality in premature infants. There are few studies on pulmonary associated morbidities observed premature. The aim this study was to investigate the possible relationship between respiratory problems infants.Material method Premature infants aged 25–32 weeks who were born January 2014 2018 neonatal intensive care unit included study. Of these infants, 28 patients diagnosed as 56 control cases with same demographic...

The aim of this study was to investigate the pulmonary function pediatric patients with COVID-19 after recovery.Pediatric aged 5-18 years hospitalized diagnoses and discharged recovery were included in prospective study. Pulmonary tests (PFTs) performed through spirometry.The patient group consisted 34 children control 33. forced vital capacity (FVC%) values groups 110.62±11.71 94.21±13.68 (p<0.001), expiratory volume first second (FEV1%) 104.91±6.26 98.67±14.93 (p=0.032), FEV1/FVC%...