A5072600554- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Vascular anomalies and interventions
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
John Paul II Hospital
2015-2024
Andrzej Frycz Modrzewski Krakow University
2024
Jagiellonian University
2012-2021
Christ Hospital
2012
Medical University of Silesia
2012
Christ Hospital
2012
Despite a growing understanding of the role played by plaque morphology, degree carotid lumen reduction remains principle parameter in decisions on revascularization symptomatic and asymptomatic patients. Computed tomography angiography (CTA) is widely used guideline-approved imaging modality, with "percent stenosis" commonly calculated as %area (area stenosis - AS).We evaluated impact non-linear relationship between diameter (DS) AS = π • (diameter/2)2, so that concentric lesions 51%AS...
Different non-invasive and invasive imaging modalities are used to determine carotid artery stenosis severity that remains a principal parameter in clinical decision-making. We compared degree obtained with different against vascular gold standard, intravascular ultrasound, IVUS.300 consecutive patients (age 47-83 years, 192 men, 64% asymptomatic) of " ≥ 50%" referred for potential revascularization received as per study protocol (i) duplex ultrasound (DUS), (ii) computed tomography...
Background: To prospectively examine the dynamic evolution of fibrotic processes within a one-year in patients with dilated cardiomyopathy (DCM). Methods: Between May 2019 and September 2020, 102 DCM (mean age 45.2 ± 11.8 years, EF 29.9 11.6%) underwent cardiac magnetic resonance (CMR-1). After 13.9 2.9 months, 92 these follow-up CMR (CMR-2). Replacement fibrosis was assessed via late gadolinium enhancement (LGE), quantified terms LGE mass extent. Interstitial evaluated T1-mapping expressed...
Effective progenitor cell recruitment to the ischemic injury zone is a prerequisite for any potential therapeutic effect. Cell uptake determinants in humans with recent myocardial infarction are not defined. We tested hypothesis that of autologous CD34(+) cells delivered via an intracoronary route after related left ventricular (LV) ejection fraction (LVEF) and infarct size.Thirty-one subjects (age, 36-69 years; 28 men) primary percutaneous coronary intervention-treated anterior...
PurposeThe aim of the study was to perform CT angiography-based evaluation aberrant right subclavian artery prevalence, anatomy, and its influence on clinical symptoms.A total 6833 patients who underwent 64-slice or dual-source angiography those revealed anatomy were interviewed for presence symptoms.Aberrant found in 32 (0.47%) consisting 13 males 19 females, with mean age 60.8±13.4 years. Among 30 (94%) patients, oesophageal compression observed 14 cases (47%) tracheal three (10%). None...
The current stratification of arrhythmic risk in dilated cardiomyopathy (DCM) is sub-optimal. Cardiac fibrosis involved the pathology arrhythmias; however, relationship between cardiovascular magnetic resonance (CMR) derived extracellular volume (ECV) and burden (AB) DCM unknown. This study sought to evaluate presence extent replacement interstitial compare degree patients with without AB. a prospective, single-center, observational study. Between May 2019 September 2020, 102 underwent CMR...
Abstract Background It is commonly accepted that myocardial fibrosis (MF) implicated in the pathology of dilated cardiomyopathy (DCM). However, MF not a “fixed” abnormality but evolves over time. unknown what natural history optimally treated DCM patients. Methods This prospective, single-center, observational study. Between May 2019 and September 2020, 90 (81 male, mean age 47.2±9.8 years, EF 34.5±12.2%) patients underwent cardiac magnetic resonance (CMR). All were with heart failure...
Abstract Purpose Ventricular arrhythmias originating from the left ventricular summit (LVS) may present with challenges for catheter ablation. Recently, atrial appendage (LAA) became a new vantage point mapping and ablating that region, but data of possible usefulness is limited. Methods From September to December 2019, we retrospectively analyzed 48 consecutive patient hearts (20 male; mean age 57.9y ± 11.56) undergoing diagnostic coronary vessel imaging in 64 dual-source computer...
Cardiac fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM) and has confirmed unfavorable clinical significance. Replacement better known already been studied on larger scale, whereas interstitial less explored.We aimed to analyze the relationship between serum biomarkers fibrosis, as assessed with cardiac magnetic resonance (CMR) in HCM patients.We performed 3T CMR scans 50 patients assess expressed by extracellular volume (ECV). In all patients, we determined levels...
Investigate the effects of left and right ventricular function severity pulmonary valve regurgitation, quantified by cardiac magnetic resonance (CMR), on exercise tolerance in adult patients who underwent ToF repair at a young age.This is retrospective cohort study 52 after surgery 33 age- sex-matched healthy volunteers. CMR cardiopulmonary testing (CPET) were performed all patients; CPET was control subjects.The main finding severe decrease oxygen uptake peak VO2peak TOF patients. The...
Non-sustained ventricular tachycardia (nsVT) creates the electrical basis for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). We aimed to evaluate relationship between interstitial fibrosis on magnetic resonance (CMR) and nsVT HCM. A total of 50 HCM patients underwent CMR with a 3 T scanner determine presence replacement expressed by late gadolinium enhancement (LGE), native T₁, post-contrast extracellular volume (ECV). The incidence was assessed Holter monitoring. detected...
Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation immune-cell recruitment. Interleukin -6 (IL-6) used as a general index severity chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) an immune biomarker potentially regulation valve fibrosis calcification. The aim this study was to analyze selected biomarkers associated with different stages immune-pathogenesis aortic stenosis. Forty consecutive...
Background Analysis of morphometric details aortic coarctation and collateral circulation using computed tomography (CT) its impact on clinical symptoms is a perspective which missing in the published literature. Purpose To perform CT-based qualitative quantitative evaluation with reference to symptoms. Material Methods The study comprised 2022 patients who underwent CT angiography. If was seen, anatomy associated Results Aortic found 33 patients. Follow-up (median 2476 days; range...
Abstract Continuous flow left ventricular assist device (LVAD) outflow graft stenosis constitutes a severe complication. Treatment options include surgical pump exchange, transcatheter procedures, or systemic thrombolysis. We present case of spontaneous mechanical twisting the at two distinct points, which was treated by two‐step percutaneous stent implantation. Self‐expanding stents were used during first procedure. also ensured distal bilateral neuroprotection against cerebrovascular...
The aim of the study was to perform qualitative and quantitative computed tomography (CT) angiography-based evaluation patent ductus arteriosus (PDA) morphology its influence on great vessels.Two-thousand twenty-two patients underwent 64-slice or dual-source CT were retrospectively screened for presence PDA. Those who had PDA anatomy morphology.Thirty-two adult with evaluated (mean age 41.4 ± 17.4 years). Subjects a higher value aortic isthmus (p = 0.0148), main pulmonary artery < 0.0001),...
The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare biomarkers DCM patients with high low burdens, we performed a prospective, single-center, observational study. study population was composed of 100 (87 male, mean age 45.2 ± 11.8 years, ejection fraction 29.7% 10.1%). Replacement quantified by means late gadolinium enhancement (LGE), whereas interstitial assessed via...
Background Anomalous origin of the left coronary artery from pulmonary (ALCAPA) is a rare congenital cardiac anomaly which requires surgical treatment, improves ventricular function and clinical outcomes. The definitive diagnosis ALCAPA based on angiography, however, noninvasive visualization often helpful in ALCAPA.Objectives purpose this study was to evaluate techniques for ALCAPA, present outcomes adults after correction ALCAPA.Methods Medical charts five patients with treated at John...
Ewing's sarcoma (ES) and primitive neuroectodermal tumour (PNET) are now considered to be the same usually occur in long bones. Extraskeletal is an extremely rare neoplasm, accounting for 1% of soft tissue sarcomas, with most common location thorax. Gallbladder cancer (GBC) represents type among biliary tract cancers a poor prognosis even patients undergoing aggressive therapy. We present study extraskeletal ES/PNET found hilus liver elderly, diagnosed one month prior GBC woman. The patient...
Dilated cardiomyopathy (DCM) is distinguished by left ventricle (LV) dilation accompanied systolic dysfunction. However, some studies suggested also a high prevalence of LV diastolic dysfunction (LVDD), similar to general cohort heart failure (HF) with reduced ejection fraction (LVEF). The bulk evidence, mostly arising from basic studies, suggests causative link between cardiac fibrosis (CF) and LVDD. still, there remains scarcity data on LVDD CF. Therefore, the aim study was investigate...