A5029867651- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism and Genetic Disorders
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Microbial metabolism and enzyme function
- Systemic Lupus Erythematosus Research
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Regulation of Appetite and Obesity
- Amino Acid Enzymes and Metabolism
- Diabetes and associated disorders
- Apelin-related biomedical research
- Sexuality, Behavior, and Technology
- Trace Elements in Health
Czech Academy of Sciences, Institute of Experimental Medicine
2009-2025
Institute of Experimental Medicine
2001-2024
St Petersburg University
2018-2022
Russian Academy of Sciences
1998-2015
Academy of Medical Sciences
2012
First Pavlov State Medical University of St. Petersburg
2010
In this work, we determined the content of antibodies to low-density lipoproteins modified by malondialdehyde, concentration circulating immune complexes cholesterol and oxidized in blood healthy individuals patients with various manifestations atherosclerosis. addition, effect malondialdehyde on interaction such macrophages was studied. 253 persons were examined: (59 people), preclinical atherosclerosis (25 people) coronary artery disease (169 people). It found that plasma increased...
Familial hypercholesterolemia is a human monogenic disease caused by population-specific mutations in the low density lipoprotein (LDL) receptor gene. Despite thirteen different of LDL gene were reported from Russia prior to 2003, whole spectrum disease-causing alterations this country poorly known and requires further investigation provided current study.Forty-five patients with clinical diagnosis FH tested for apolipoprotein B (apoB) mutation R3500Q restriction fragment length analysis....
Dysregulation of adipose tissue functions makes a significant contribution to the pathogenesis metabolic syndrome, one most common diseases in recent years. Adipose is an organ that secretes at least several dozen signaling molecules, adipokines. One studied and same time mysterious adipokines adiponectin. The latter due lack clear ideas about biological role this adipokine, presence its molecular forms with different activity types receptors adipokine localized almost all cells body....
Background:Amitochondrialspecificdeacetylase,Sirtuin-3hasbeenreportedtoregulateoxidative phosphorylation, the activity of Cyclophilin D (a key component mitochondrial permeability transition pore, MPTP), and ROS scavenger MnSOD. We hypothesised that Sirtuin-3 could be a potential therapeutic target for cardio-protection based its ability to prevent MPTP formation inhibit generation. MethodsandResults:InHL-1cells(amurinecardiaccellline),over-expressionofSirtuin-3reduced cell death following...
Aim of the study This is dedicated to evaluation prevalence metabolic syndrome and its components in patients with schizophrenia Russia. Subject or material methods 138 who received antipsychotic medication mental healthy subjects from 1,561 bank employees cohort matched schizophrenic by sex, age body mass index were enrolled study. Fasting blood plasma levels glucose, lipids, insulin, cortisol, prolactin concentrations determined. Results In comparison control group had significantly higher...
We used polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis to detect LDL receptor gene defects in the St. Petersburg population. have found a deltaG197 mutation several patients of Jewish origin. The named is shown be responsible for one-third (7/23) familial hypercholesterolemia (FH) cases Jews and absent Russian descent. prevalence consistent with its origin Lithuania or Poland. can easily detected polyacrylamide minigels because formation specific...
Specific autoantibodies against acetylated, maleylated and malonic dialdehyde-(MDA)-modified lipoproteins are detectable in human plasma. Immunization of rabbits with autologous, correspondingly modified low-density (LDLs) did induce MDA-modified lipoproteins. In atherosclerotic lesions from hyman aorta, the epitopes have been detected that were recognized by antibodies to maleylated, LDLs. Such antigens at all atherogenesis stages, beginning earliest (lipid spots), their deposition pattern...
The purpose of the study was to reveal a possible role adipokines, biologically active adipose tissue proteins (leptin and adiponectin) nonesterified fatty acids in generating insulin resistance (IR). One hundred fifty-seven patients (90 females 67 males) aged 57.5±9.2 years were enrolled study. According HOMA index for IR, divided into 3 equal groups. examinees with high found have elevated levels acids, leptin decreased concentrations adiponectin. At same time according linear regression...
BACKGROUND: Modified low-density lipoproteins have immunogenic properties and induce the production of antibodies. In this case, HOCl promotes formation subsequent active halogen-containing compounds interacting with proteins lipid parts lipoproteins, which leads to their modification antibodies them. AIM: The aim work is isolate hypochlorite modified from human blood sera study specificity. MATERIALS AND METHODS: Malondialdehyde, acetic anhydride sodium were used obtain lipoproteins. IgG...
BACKGROUND: Cytokines are important participants in the atherosclerotic process. The product of T-helpers and mast cells, interleukin-4, causes activation endothelial cells induces polarization macrophages into anti-inflammatory M2 phenotype. AIM: aim was to study influence interleukin-4 on transendothelial transport low-density lipoproteins. MATERIALS AND METHODS: Low-density lipoproteins evaluated a two-chamber model monolayer human cell line EA.hy926. For that, 200 mkg/ml lipoproteins, 1,...
Metabolic syndrome, a cluster of interrelated disorders including abdominal obesity, insulin resistance, dyslipidemia, and hypertension (HTN) plays an important role in development atherosclerotic lesions arterial wall. Dysregulation adipose tissue hormones (adipokines) production is possible link between obesity other manifestations metabolic syndrome. Adiponectin well-known adipokine which affects metabolism inflammatory response. However, data on its atherogenesis are still controversial....
Эндотелий выполняет важную роль в регуляции сосудистого гомеостаза, являясь непосредственной зоной контакта между циркулирующей кровью и прилегающими к сосудистой стенке тканями. При этом на монослой эндотелиальных клеток стенки действуют механические силы, вызываемые изменениями параметров кровотока. поражении сосудов под действием патологических факторов первую очередь происходит деструкция эндотелиального гликокаликса (ЭГ). Это является важным для начала дальнейшего развития...
The review is devoted to discussion the data regarding involvement of adipocytes’ secreting protein, adiponectin, in atherogenesis. questions relating structure its molecular forms, mechanisms production and signaling are also considered. Based on analysis clinical studies results obtained animals cell cultures it thought that adiponectin has both antiatherogenic proatherogenic properties.