A5101719383- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Effects and risks of endocrine disrupting chemicals
- Receptor Mechanisms and Signaling
- Toxic Organic Pollutants Impact
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Colorectal Cancer Treatments and Studies
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Hypothalamic control of reproductive hormones
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Pharmaceutical and Antibiotic Environmental Impacts
- Genomics and Phylogenetic Studies
- Ion channel regulation and function
- Animal Nutrition and Physiology
- Metastasis and carcinoma case studies
- Animal Genetics and Reproduction
- Thermal Regulation in Medicine
- Thyroid Disorders and Treatments
Astellas Pharma (Japan)
2008-2019
Aichi Cancer Center
1981-2018
National Institute for Environmental Studies
2005-2017
Kokura Memorial Hospital
2015
Deleted Institution
2013
Kagawa Nutrition University
2012
Nagoya City University
2002-2007
Mizuho (Japan)
2007
Tohoku Gakuin University
2007
Gifu University
2000-2005
The G protein-coupled receptor (GPCR) family is highly diversified and involved in many forms of information processing. SREB2 (GPR85) the most conserved GPCR throughout vertebrate evolution expressed abundantly brain structures exhibiting high levels plasticity, e.g., hippocampal dentate gyrus. Here, we show that determining size, modulating diverse behaviors, potentially vulnerability to schizophrenia. Mild overexpression caused significant weight reduction ventricular enlargement...
The effects of 3-methyl-4-nitrophenol (PNMC), a component diesel exhaust, on reproductive function were investigated in adult male Japanese quail. quail treated with single i.m. dose PNMC (78, 103 or 135 mg/kg body weight), and trunk blood testes collected 1, 2 4 weeks later. Various levels testicular atrophy observed all groups PNMC. Sperm formation, cloacal gland area, plasma LH testosterone concentrations also reduced birds atrophy. To determine the acute effect gonadotrophin from...
The K + channel, one of the determinants for neuronal excitability, is genetically heterogeneous, and various channel genes are expressed in CNS. therapeutic potential blockers cognitive enhancement has been discussed, but contribution each gene makes to function remains obscure. BEC1 (KCNH3) a member superfamily that shows forebrain-preferential distribution. Here, we show critical involvement function. knock-out mice performed behavioral tasks related working memory, reference attention...
In the present study, changes in localization of nerve growth factor (NGF) and its receptors, trkA p75 ovary were investigated during estrous cycle golden hamster. The effect LH surge on NGF, was also investigated. NGF receptors localized oocytes, granulosa cells theca various stages follicles throughout cycle. two numerous interstitial luteal cells. number staining positively for greater ovaries day 1 (day 1=day ovulation) than other days Treatment with antiserum against luteinizing hormone...
To investigate the effect of hypothyroidism on gonadal and adrenal functions in male Japanese quail (Coturnix japonica), was induced adult by daily administration 2-Mercapto-1-methylimidazole (methimazole) their drinking water. Four weeks after methimazole treatment, were scarificed, plasma concentrations free triiodothyronine (FT3), thyroxine (FT4), total T3 (TT3), T4 (TT4), corticosterone, testosterone, LH immunoreactive (ir) inhibins measured radioimmunoassy, testes glands removed weighed...
Recent epidemiological investigations have observed an association between the consumption of grilled or barbecued meat and increased risk pancreatic cancer, suggesting that dietary exposure to heterocyclic aromatic amines (HCA) may contribute development this disease. 2-Amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP) is most abundant HCA found in well-done meats. To determine whether HCA-induced DNA damage present human pancreas, immunohistochemistry computer-assisted image analysis...
PTEN is a tumor suppressor gene and its mutation frequently found in endometrial carcinoma. Recently, the pseudogene of has been reported to be actively transcribed number cells tissues potential for translation suggested. For further understanding involvement carcinogenesis, we analysed expressions 36 carcinomas with special reference genetic status PTEN. Mutations were 42% (15/36) carcinomas. The transcript was expressed 6 samples (17%) carcinomas, but none normal endometria. Western blot...
ABSTRACT Human isolates of serotype III Streptococcus agalactiae (group B streptococcus [GBS]) can be divided into three separate phylogenetic lineages based on analysis the restriction digest patterns (RDPs) chromosomal DNA. Nine DNA sequences that are present in all RDP III-3 lineage, but not other lineages, were identified by genomic subtractive hybridization. A complete physical map a chromosome was constructed. Six nine III-3-specific mapped to 340-kb Sse 8387I fragment which contains...
In a previous study, we found that 3-methyl-4-nitrophenol (PNMC), component of diesel exhaust particles and also degradation product the insecticide fenitrothion, exhibits reproductive toxicity in adult male Japanese quail. The present study investigated PNMC female quail its ability to influence reproduction immature females. (21-day-old) were injected intramuscularly (im) with at doses 0.1, 1 or 10 mg/kg body weight daily for 3 days. There was no significant difference growth between...
To assess the genetic diversity of domestic Japanese quail (Coturnix japonica) populations, and their relationships, we examined mitochondrial DNA (mtDNA) D-loop sequences microsatellite markers for 19 populations. The populations included nine laboratory lines established in Japan (LWC, Quv, RWN, WE, AWE, AMRP, rb-TKP, NIES-L, W), six meat-type reimported from Western countries (JD, JW, Estonia, NIES-Br, NIES-Fr, NIES-Hn), one commercial population Japan, three wild collected Asian areas....
Background/Aim: We investigated whether measuring the excretion of each acute kidney injury (AKI) biomarker after cisplatin (CDDP) administration is useful for predicting AKI and evaluated most appropriate marker in patients treated with CDDP. Patients Methods: measured NAG, Kim-1, NGAL urinary samples 40 cancer chemotherapy on day 1 (before chemotherapy), 2, 5 treatment; serum creatinine (sCr) was compared days 7 28 CDDP vs. baseline. Results: (creatinine corrected) were not significantly...
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. KCNH3 concentrated forebrain, its overexpression mice leads to cognitive deficits. In contrast, Kcnh3 knockout exhibit enhanced performance tasks such as attention. These data suggest plays important roles cognition. Here we investigated...
Department of Anesthesiology, University Tsukuba Institute Clinical Medicine, City, Ibaraki, Japan. Accepted for publication August 12, 1998. Address correspondence and reprint requests to Y. Fujii, 2-1-1, Amakubo, Ibaraki 305,
To clarify the physiological roles of estrogens in regulation sperm motility golden hamster, two different approaches were used. In first experiment, silastic tubes containing either low (low E2 group) or high (high amount estradiol-17beta implanted (Exp 1). second male hamsters actively immunized against 2). Exp 1, all parameters (including motility, straight velocity, curvilinear beat/cross frequency, and mean amplitude lateral head displacement) significantly increased except linear index...