A5003126402- Cell Adhesion Molecules Research
- Intraocular Surgery and Lenses
- vaccines and immunoinformatics approaches
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Endoplasmic Reticulum Stress and Disease
- SARS-CoV-2 and COVID-19 Research
- Corneal Surgery and Treatments
- Cellular transport and secretion
- Retinal and Macular Surgery
University of Siena
2019-2022
Italian institute for Genomic Medicine
2022
In the endothelium, single-pass membrane protein CD93, through its interaction with extracellular matrix Multimerin-2, activates signaling pathways that are critical for vascular development and angiogenesis. Trafficking of adhesion molecules endosomal compartments modulates their output. However, mechanistic basis coordinating CD93 recycling implications endothelial cell (EC) function remain elusive.Human umbilical vein ECs (HUVECs) human dermal blood (HDBEC) were used in this study....
During skeletal myogenesis, the zinc-finger transcription factors SNAI1 and SNAI2, are expressed in proliferating myoblasts regulate transition to terminally differentiated myotubes while repressing pro-differentiation genes. Here, we demonstrate that is upregulated vivo during early phase of muscle regeneration induced by bupivacaine injury. Using shRNA-mediated gene silencing C2C12 whole-transcriptome microarray analysis, identified a collection genes belonging endoplasmic reticulum (ER)...
Purpose: This work was aimed to further characterize cells of idiopathic epiretinal membranes (iERMs). We wanted determine the contribution 90-kDa heat shock protein (HSP90) sustain transforming growth factor-β (TGF-β)-mediated signal transduction pathway in iERM. Methods: Immunofluorescence and confocal microscopy were carried out on deplasticized sections from 36 processed for electron frozen five additional samples with antibodies against α-smooth muscle actin (αSMA), vimentin, glial...