A5048652132- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Nuclear physics research studies
- Nuclear reactor physics and engineering
- Neurobiology of Language and Bilingualism
- Pain Management and Placebo Effect
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Renal function and acid-base balance
- Cancer-related cognitive impairment studies
- Diet and metabolism studies
- Urban Green Space and Health
- Language Development and Disorders
- Quantum, superfluid, helium dynamics
- Social and Intergroup Psychology
- Systemic Lupus Erythematosus Research
- Glioma Diagnosis and Treatment
- Interpreting and Communication in Healthcare
Lund University
2016-2025
Scania (Sweden)
2024
Max Planck Institute for Human Development
2013-2017
University Hospital Schleswig-Holstein
2016
University of Lübeck
2016
Yonsei University
2016
Clinical Research Center Kiel
2016
Eurocontrol
2016
Max Planck Society
2014
Eskilstuna Municipality
2004
In diffusion MRI (dMRI), microscopic anisotropy can be obscured by orientation dispersion. Separation of these properties is high importance, since it could allow dMRI to non-invasively probe elongated structures such as neurites (axons and dendrites). However, conventional dMRI, based on single encoding (SDE), entangles dispersion with intra-voxel variance in isotropic diffusivity. SDE-based methods for estimating anisotropy, the neurite density imaging (NODDI) method, must thus rely model...
Abstract We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20–30 years) and 47 older (60–70 adults, each measured magnetic resonance imaging (MRI) over three successive time points, separated four months. Retest correlations were very high for both segmentations. With FreeSurfer, significantly lower the than age group, which was not case segmentation. Pearson between estimates sufficiently high, numerically even higher...
Abstract In vivo mapping of the neurite density with diffusion MRI (dMRI) is a high but challenging aim. First, it unknown whether all neurites exhibit completely anisotropic (“stick‐like”) diffusion. Second, “density” tissue components may be confounded by non‐diffusion properties such as T2 relaxation. Third, domain validity for estimated parameters to serve indices incompletely explored. We investigated these challenges acquiring data “b‐tensor encoding” and multiple echo times in brain...
Enriched environments elicit brain plasticity in animals. In humans it is unclear which environment enriching. Living a city has been associated with increased amygdala activity stress paradigm, and being brought up pregenual anterior cingulate cortex (pACC) activity. We set out to identify geographical characteristics that constitute an enriched affecting the human brain. used structural equation modelling on 341 older adults establish three latent factors (amygdala, pACC dorsolateral...
To optimize diffusion-relaxation MRI with tensor-valued diffusion encoding for precise estimation of compartment-specific fractions, diffusivities, and T2 values within a two-compartment model white matter, to explore the approach in vivo.Sampling protocols featuring different b-values (b), b-tensor shapes (bΔ ), echo times (TE) were optimized using Cramér-Rao lower bounds (CRLB). Whole-brain data acquired children, adults, elderly matter lesions. Compartment estimated two microstructural...
Evidence for experience-dependent structural brain change in adult humans is accumulating. However, its time course not well understood, as intervention studies typically consist of only 2 imaging sessions (before vs. after training). We acquired up to 18 magnetic resonance images over a 7-week period while 15 right-handed participants practiced left-hand writing and drawing. After 4 weeks, we observed increases gray matter both left right primary motor cortices relative control group; 3...
Adequate reliability of measurement is a precondition for investigating individual differences and age-related changes in brain structure. One approach to improve identify control variables that are predictive within-person variance. To this end, we applied both classical statistical methods machine-learning-inspired approaches structural magnetic resonance imaging (sMRI) data six participants aged 24–31 years gathered at 40–50 occasions distributed over 6–8 months from the Day2day study. We...
Childhood adversity (CA) leads to greater vulnerability for psychopathology by causing structural as well functional brain abnormalities. Recent findings on gray matter effects point towards the importance of identifying CA outcome a function different types, varying in dimensions threat and deprivation. Using diffusion tensor imaging, we investigate whether forms impact differently white connectivity healthy cohort not confounded other aspects disease.In 120 young males, assessed...
Abstract Coming from a disadvantaged background can have negative impact on an individual’s educational trajectory. Some people however seem unaffected and cope well with the demands challenges posed by school education, despite growing up in adverse conditions, phenomenon termed academic resilience . While it is uncertain which underlying factors make some more likely to circumvent unfavorable odds than others, both socioeconomic status (SES) cognitive ability robustly been linked...
MR-generated acoustic noise may be particularly concerning at 7-Tesla (T) systems. Noise levels can reduced by altering gradient output using software optimization. However, such alterations might influence image quality or prolong scan times, and these optimizations have not been well characterized. To evaluate quality, sound pressure (SPLs), perceived when the reduction technique SofTone for T2-weighted fast spin echo (T2W FSE) three-dimensional T1-weighted turbo field (3D T1W TFE), to...
Most studies of brain structure and function, their relationships to cognitive ability, have relied on inter-individual variability in magnetic resonance (MR) images. Intra-individual is often ignored or implicitly assumed be equivalent the former. Testing this assumption empirically by collecting enough data single individuals cumbersome costly. We collected a dataset multiple MR sequences behavioural covariates quantify characterize intra-individual images for individuals. Eight...
Aim The aim of this study was to evaluate the extent white matter lesions, atrophy hippocampus and corpus callosum, their correlation with cognitive dysfunction (CD), in patients diagnosed systemic lupus erythematosus (SLE). Methods Seventy SLE 25 healthy individuals (HIs) were included study. To different neuropsychiatric (NPSLE) definition schemes, grouped both according American College Rheumatology (ACR) definition, as well more stringent ACR-Systemic Lupus International Collaborating...
The effects of nature on physical and mental health are an emerging topic in empirical research with increasing influence practical recommendations. Here we set out to investigate the association between spending time outdoors brain structural plasticity conjunctions self-reported affect.We established Day2day study, which includes unprecedented in-depth assessment variability structure a serial sequence 40-50 magnetic resonance imaging (MRI) acquisitions each six young healthy participants...
Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to development primary hyperalgesia at site injury, and secondary in normal surrounding injury. Secondary is inducible most individuals attributed central neuronal sensitization. Some develop large areas (high-sensitization responders), while others small (low-sensitization responders). The magnitude each area reproducible within individuals, can be regarded as a phenotypic characteristic. To study...