A5102757758- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Intensive Care Unit Cognitive Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal Tumor Research and Treatment
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Intraperitoneal and Appendiceal Malignancies
- Congenital Ear and Nasal Anomalies
- Gallbladder and Bile Duct Disorders
- Global Cancer Incidence and Screening
- Diversity and Career in Medicine
- Chemotherapy-related skin toxicity
- Surgical Simulation and Training
- Surgical site infection prevention
- Vascular Anomalies and Treatments
- Eosinophilic Esophagitis
International University of Health and Welfare
2021-2025
Keio University
1990-2025
Thomas Jefferson University
2024
Midorigaoka Hospital
2023
Showa University
2023
Hakodate Central General Hospital
2021-2022
Japanese Red Cross Narita Hospital
2022
Keio University Hospital
2016-2021
Thomas Jefferson University Hospital
2020
Nagano Municipal Hospital
2020
Importance Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but safety this approach is unknown. Objective To compare rates invasive cancer patients with DCIS receiving active vs care. Design, Setting, and Participants Prospective, randomized noninferiority trial enrolling 995 women aged 40 years or older a new diagnosis hormone receptor–positive grade 1 2 without at 100 US Alliance Cancer...
The number of dissected lymph nodes (LNs), surgical outcomes, and postoperative recurrence-free survival (RFS) were compared between thoracic duct (TD)-preserved TD-resected groups. distribution metastasis in LNs around TD (TDLN) was reviewed. Transthoracic esophagectomy (TTE) with resection for esophageal cancer patients has been one the standard procedures. Because adipose tissue surrounding contains LNs, might be necessary radical LN dissection. However, few studies have investigated...
Postoperative delirium is common after extensive surgery, and known to be associated with sleeping medications. In this study, we aimed investigate the relationships between medications postoperative pharyngolaryngectomy esophagectomy. We performed a retrospective analysis of 65 patients who underwent esophagectomy at Shizuoka Cancer Center Hospital January 2012 March 2016. All data were assessed by two psychiatrists, univariate multivariate analyses performed. developed in 9 (13.8%)...
Histamine H1 receptor (H1R) antagonists are widely used to treat allergic reactions; however, their effects on the central nervous system can impair motor functions. This study investigated impact of first-generation (diphenhydramine and d -chlorpheniramine) second-generation (epinastine, ketotifen, bepotastine, levocetirizine) H1R functions in mice using activity wheel, balance beam, inclined screen, rotarod tests. First-generation significantly impaired functions, with diphenhydramine...
Pharyngolaryngectomy with total esophagectomy (PLTE) is an effective surgical treatment for synchronous or metachronous hypopharyngeal laryngeal cancer and thoracic esophageal cancer, although it more invasive than pharyngolaryngectomy. The aim of this study was to identify risk factors complications after PLTE. From November 2002 December 2014, a 8 patients underwent PLTE at the Shizuoka Cancer Center Hospital, Shizuoka, Japan. We investigated clinicopathological characteristics,...
Abstract Background Perforation of a duodenal diverticulum is rare complication that may become fatal with delay in appropriate treatment. However, the optimal treatment for perforated remains controversial, ranging from conservative therapy to surgery including pancreatoduodenectomy. Case presentation The patient was 60-year-old woman no particular medical history who visited our hospital chief complaints continuous fever and right dorsal pain. Upon arrival, she had tenderness upper...
Abstract Background Despite the poor prognosis of recurrent esophageal squamous cell cancer (ESCC), long‐term survival could be achieved in a subset patients who successfully underwent surgical resection for recurrence. In this study, we investigated outcomes lymph node (LN) or pulmonary (PUL) recurrence ESCC patients. Methods We retrospectively analyzed between January 2008 and March 2015 either LN PUL after complete response (CR) by chemoradiotherapy R0 esophagectomy. Every patient...
Remdesivir, dexamethasone, and baricitinib have recently been used to treat patients with coronavirus disease 2019 (COVID-19) respiratory failure. However, the adverse effects of combination therapy not fully explored. A 64-year-old man was diagnosed COVID-19 treated remdesivir, baricitinib. His condition worsened on day 17, in following days, he pneumomediastinum COVID-19-associated pulmonary aspergillosis (CAPA). improved a reduction corticosteroid regime antifungal treatment. This is...
Gastrointestinal (GI) metastases from lung cancer are relatively rare, and their management strategies outcomes in the era of immune checkpoint inhibitors unknown. A 59-year-old man with was hospitalized. He presented vomiting due to a small intestinal metastasis. The metastatic lesion reduced size pembrolizumab treatment. However, patient could not feed orally required continuous central venous nutrition. Following recurrence catheter-related bloodstream infection, underwent resection...
Background: Patients with esophageal squamous cell cancer (ESCC) have a high frequency to coincide head and neck (HNC). This study aims analyze the treatment results prognosis of patients synchronous ESCC HNC. Methods: From January 2016 December 2019, 5 underwent concurrent surgical resection HNC in our institution. We retrospectively reviewed outcomes these (HNEC group) compared those 20 who esophagectomy three regional lymph node dissections for during same period (EC group). Results: The...
【目的】胸部食道切除後の胸腔ドレーン排液量は個々の症例において様々である.今回,われわれは食道癌切除再建後のドレーン排液量とその臨床的意義に関して検討した.
Background As the elderly population increases, cases of advanced gastric cancer (AGC) also increase. This study aims to investigate safety and utility curative gastrectomy, as well efficacy laparoscopic for these patients. Methods We retrospectively analyzed surgical outcomes patients with cStage IB-III AGC who underwent distal gastrectomy (DG) D2 lymph node dissection in our institution. compared results between (>75 years) non-elderly (<75 years). further divided into 2...
症例1:77歳の男性，胸部中部食道癌 T1bN0M0 cStage IAに対し根治的化学放射線療法（CRT）を施行，complete response（CR）を得た．4年後の上部消化管内視鏡検査（EGD）にて局所再発を認め，光線力学療法（photodynamic therapy:PDT）を施行．その2カ月後に再発を認め，右開胸開腹食道亜全摘を施行した．術後3年8カ月経過するが無再発生存中である．症例2:56歳の男性，胸部中部食道癌 Stage IAに対し化学放射線療法を施行，CRを得た．CRT後5年のEGDにて局所再発を認め，内視鏡的粘膜剥離術，PDTを同時に施行した．1年6カ月後に局所再発を認め，右開胸開腹食道亜全摘を施行した．術後3カ月経過するが無再発生存中である．PDT後の局所遺残再発に対する食道切除術を行い良好な経過を得た2症例を経験したので報告する．
われわれは頸部食道癌術後外側咽頭後リンパ節（Rouviere）転移症例4例を経験した．頸部食道癌に対する初回治療は手術が3例，化学放射線療法が1例であった．症例1:術後2カ月目にRouviere転移を認め化学放射線療法を行ったが，奏効せず術後7カ月目に死亡した．症例2:術後2カ月目にRouviere単独再発をきたし，化学療法にて完全奏効が得られ術後5年生存中である．症例3:術後43カ月目に右Rouviere単独再発をきたしCRTを行い，完全奏効が得られ術後5年生存中である．症例4:初回治療のCRT後8カ月目に両側Rouviere再発をきたしサルベージ手術を施行したが，切除困難であり初回CRT後19カ月目に死亡した．頸部食道癌においてRouviereは領域リンパ節として選定されてはおらず遠隔転移として考慮される病変であるが，自験例4例中2例は治療が奏効し，長期予後が得られており，早期の再発診断，治療を行うことが重要であると考えられた．
Supplementary Date from Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab Resectable Head and Neck Squamous Cell Carcinoma
Supplementary Figure from Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab Resectable Head and Neck Squamous Cell Carcinoma