A5046657367- Angiogenesis and VEGF in Cancer
- Microgrid Control and Optimization
- Perfectionism, Procrastination, Anxiety Studies
- Renin-Angiotensin System Studies
- Power Systems and Renewable Energy
- Impact of Technology on Adolescents
- Genetic Mapping and Diversity in Plants and Animals
- Maternal Mental Health During Pregnancy and Postpartum
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pancreatic function and diabetes
- Single-cell and spatial transcriptomics
- Hormonal Regulation and Hypertension
- Job Satisfaction and Organizational Behavior
- Islanding Detection in Power Systems
- Psychological Well-being and Life Satisfaction
- Work-Family Balance Challenges
- Behavioral Health and Interventions
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Child Development and Digital Technology
- Genomic variations and chromosomal abnormalities
- Cancer survivorship and care
- Renal and related cancers
- Emotional Labor in Professions
- Error Correcting Code Techniques
Henan University
2021-2024
Nanjing Medical University
2024
Dali University
2005-2024
Shanghai Electric (China)
2022-2023
Regeneron (United States)
2011-2022
The University of Sydney
2022
Tongji University
2014
Cold Spring Harbor Laboratory
2011
Jackson Laboratory
2008-2010
University of Iowa
1997-2001
Abstract Angiogenesis involves dynamic interactions between specialized endothelial tip and stalk cells that are believed to be regulated in part by VEGF Dll4-Notch signaling. However, our understanding of this process is hampered limited knowledge the heterogeneity role different signaling pathways specifying phenotypes. Here, we characterized single-cell transcriptomics mouse other stromal during active angiogenesis xenograft tumors as well from adult normal heart, following pharmacologic...
A set of 1638 informative SNP markers easily assayed by the Amplifluor genotyping system were tested in 102 mouse strains, including majority common and wild-derived inbred strains available from The Jackson Laboratory. Selected publicly databases, are on average ∼1.5 Mb apart and, whenever possible, represent rare allele at least two strains. assays developed for each marker performed independent DNA samples strain. mean number polymorphisms between was 608±136 SD. Several tests indicate...
Genetic maps provide a means to estimate the probability of co-inheritance linked loci as they are transmitted across generations in both experimental and natural populations. However, age whole-genome sequences, physical distances measured base pairs DNA standard coordinates for navigating myriad features genomes. Although genetic colinear, there well-characterized sometimes dramatic heterogeneities average frequency meiotic recombination events that occur along extent chromosomes. There...
We report the development and optimization of reagents for in-solution, hybridization-based capture mouse exome. By validating this approach in a multiple inbred strains novel mutant strains, we show that whole exome sequencing is robust discovery putative mutations, irrespective strain background. found strong candidate mutations majority exomes sequenced, including new models orofacial clefting, urogenital dysmorphology, kyphosis autoimmune hepatitis.
Abstract A complete chart of the chromatin regulatory elements immune cells in patients with cancer and their dynamic behavior is necessary to understand developmental fates guide therapeutic strategies. Here, we map single-cell landscape from blood, normal tumor-adjacent kidney tissue malignant early-stage clear cell renal carcinoma (ccRCC). We catalog T states dictated by tissue-specific developmental-stage-specific accessibility patterns, infer key regulators observe rewiring networks...
Transgenic mice were generated containing a 1542-base pair fragment of the kidney androgen-regulated protein (KAP) promoter fused to human angiotensinogen (HAGT) gene with goal specifically targeting inducible expression renin-angiotensin system components kidney. High level both KAP-HAGT and endogenous KAP mRNA was evident in male from two independent transgenic lines. Renal transgene female undetectable under basal conditions but could be strongly induced by administration testosterone....
Davisson, Robin L., Yueming Ding, David E. Stec, James F. Catterall, and Curt D. Sigmund. Novel mechanism of hypertension revealed by cell-specific targeting human angiotensinogen in transgenic mice. Physiol. Genomics 1: 3–9, 1999.—We tested the hypothesis that tissue-specific intrarenal renin-angiotensin system (RAS) can participate regulation blood pressure independently its endocrine counterpart, generating two models differ their expression (AGT). Human AGT was driven endogenous promoter...
To investigate the influence of perceived organisational justice, professional identity and emotional labour on nurses' job performance.Previous studies have not explored impact relationship between justice performance. However, how to mobilize enthusiasm nurses improve their performance is key for nursing managers realize sustainable development hospitals.A cross-sectional survey design was conducted. A total 951 from public hospitals in China participated March-June 2021. The descriptive...
This study aimed to explore the effect of prosocial behaviours on Chinese undergraduate nursing students' subjective well-being (SWB) and examine roles psychological resilience coping styles. The sample for this included 683 students from two universities in Henan Province, China. SWB, behaviours, resilience, styles were assessed by Index Well-Being, Prosocial Behavioural Tendency Scale, Connor-Davidson Resilience Simplified Coping Style Questionnaire, respectively. We adopted Pearson's...
This study aimed to investigate the associations between perfectionism and undergraduate nursing students' academic procrastination, mediating effects of self-efficacy moderating role resilience.A cross-sectional survey.The survey was conducted from March May 2022 with a sample 587 students in two universities China. A descriptive statistical approach, Pearson's correlation analysis Hayes' PROCESS Macro model 4 14 were used analyse available data.Adaptive maladaptive negatively positively...
Abstract Objective To investigate the relationship between work readiness and well‐being for newly graduated nurses mediating role of emotional labor psychological capital in this relationship. Methods A cross‐sectional survey was conducted mainland China. total 478 completed Work Readiness Scale, Emotional Labour Psychological Capital Questionnaire, Well‐being Scale. Descriptive statistical methods, Pearson correlation analysis, a structural equation model were used to analyze available...
Abstract Marital status has long been recognized as an important prognostic factor for many cancers, however its’ effect patients with laryngeal cancer not fully examined. We retrospectively analyzed 8834 in the Surveillance Epidemiology and End Results database from 2004 to 2010. Patients were divided into four groups: married, widowed, single, divorced/separated. The difference overall survival (OS) cancer-specific (CSS) of various marital subgroups calculated using Kaplan–Meier curve....
How to kindle the learning enthusiasm of nursing students and reduce incidence academic procrastination is an important factor in reducing student attrition improving quality education.To investigate mediating role coping style resilience on association between parenting styles among undergraduates.A cross-sectional study 683 undergraduates was conducted China from March May 2022. Parenting styles, style, resilience, were measured using questionnaires. Descriptive analysis, Pearson's...
We previously reported a novel transgenic model expressing human angiotensinogen from the kidney androgen-regulated protein promoter, and demonstrated sexually dimorphic expression. Herein, we investigated hormonal regulation of this transgene. Testosterone increased transgene expression in female mice dose- time-dependent manner was not detectable 3-days after treatment halted. High doses estrogen were required to induce Expression mRNA decreased castration male mice. As females, however,...